1/13. Hamartomas of the iris and ciliary epithelium in tuberous sclerosis complex.Astrocytic hamartomas of the retina are the principal ocular manifestation of tuberous sclerosis complex. iris abnormalities are rare in tuberous sclerosis complex and include focal areas of stromal depigmentation and atypical colobomata. We describe 2 patients who were found on histopathological examination to have lesions consistent with hamartomas of the iris pigment epithelium and ciliary body epithelium. iris abnormalities, including pupillary irregularities, were noted on clinical examination prior to the development of iris neovascularization in both patients. These observations suggest that iris abnormalities, including atypical colobomas, may be caused by hamartomas of the iris pigment epithelium and ciliary epithelium in some patients with tuberous sclerosis complex. To our knowledge, hamartomas of tissues derived from the anterior part of the neuroectodermal optic cup have not been reported in cases of tuberous sclerosis complex.- - - - - - - - - - ranking = 1keywords = neovascularization (Clic here for more details about this article) |
2/13. Toxic keratolysis from combined use of nonsteroid anti-inflammatory drugs and topical steroids following vitreoretinal surgery.PURPOSE: To evaluate the corneal complications associated with the combined use of non-steroid anti-inflammatory drugs (NSAIDs) and topical steroids following vitreoretinal surgery. METHOD: Description of corneal lesions in three patients after vitrectomy with use of topical ketorolac and prednisolone acetate. RESULTS: Three eyes of three patients developed an atrophic central corneal ulcer with stromal thinning following a pars plana vitrectomy under local anesthesia. Lesions were asymptomatic and were found during a routine examination 2, 3, and 8 weeks after surgery, respectively. Surgical indications were as follows: a preretinal membrane, choroidal neovascularization, and massive uveal effusion following cataract surgery. Topical postoperative treatment was as follows: ketorolac 4 times a day, a combination of prednisolone acetate, polymyxin b, and neomycin 6 times a day, and 1% cyclopentolate 3 times a day. Suspension of ketorolac and ocular occlusion led to the resolution of corneal lesions between 2.5 and 3 months later, yielding a central superficial scarring, which showed no changes after a follow-up of 3 years. CONCLUSIONS: Toxic keratolysis may appear as a secondary effect of the combined use of topical NSAIDs and steroids following vitreo retinal surgery and must be taken into account in the differential diagnosis of postoperative corneal lesions.- - - - - - - - - - ranking = 1keywords = neovascularization (Clic here for more details about this article) |
3/13. Massive choroidal haemorrhage as a complication of krypton red laser photocoagulation for disciform degeneration.A 78-year-old man with perifoveal subretinal neovascularization originally treated with krypton red laser was re-treated. An attempt was made to produce a "chalky white" burn at the site of the neovascular frond. Immediately after a burn, a brisk choroidal haemorrhage followed, apparently from a ruptured choroidal vessel. Bleeding occurred subretinally and into the vitreous, blinding the patient. While the krypton red laser carries advantages over the argon laser in the treatment of subretinal neovascular fronds, this case indicates that hard burns with the krypton laser carry a risk of massive subretinal haemorrhage.- - - - - - - - - - ranking = 1keywords = neovascularization (Clic here for more details about this article) |
4/13. Uveal neovascularization at the ora serrata and pars plana.Thirty-two eyes with uveal neovascularization at the ora serrata and pars plana were studied histopathologically. Chronic retinal detachment of various etiologies was the most frequently associated feature, present in 65% of the patients. In three eyes, the neovascularization took the form of an angiomatous lesion, whereas in the others, capillaries, arterioles, and venules were present. A history of glaucoma was found in 60% of the patients. Other associated findings included choroidal rupture, vitreous hemorrhage, and a history of cryotherapy. Uveal neovascularization at the ora serrata should be considered in the differential diagnosis of retinal angiomas, retinal telangiectasia, malignant melanoma, adult Coats's disease, peripheral proliferative retinopathies, and vitreous hemorrhage.- - - - - - - - - - ranking = 7keywords = neovascularization (Clic here for more details about this article) |
5/13. choroideremia associated with a subretinal neovascular membrane. Case report.choroideremia is a sex-linked chorioretinal degenerative disease, with affected male patients developing diffuse chorioretinal atrophy and female carriers, in most instances, showing only pigmentary changes with normal vision. visual acuity in male patients has been reported to be unaffected until late in the course of the disease, only after the visual fields are greatly reduced. This is a case report of a 14-year-old boy with choroideremia who had decreased visual acuity secondary to a subretinal neovascular membrane in the macula of his right eye. This is the first report of choroidal neovascularization associated with this disease.- - - - - - - - - - ranking = 1keywords = neovascularization (Clic here for more details about this article) |
6/13. Subretinal neovascular membranes associated with choroidal nonperfusion and retinal ischemia.This is the first well-documented case of co-existent underlying choroidal nonperfusion in an eye with a subretinal neovascular membrane that was subsequently treated with krypton red laser photocoagulation by the senior author (LEM). The possible role of chronic macular ischemia secondary to choroidal circulatory impairment is discussed in relationship to other well-established risk factors. Perhaps treatment to improve macular oxygenation would be a reasonable alternative to eradication of the neovascularization by direct laser photocoagulation.- - - - - - - - - - ranking = 1keywords = neovascularization (Clic here for more details about this article) |
7/13. Peripheral retinal neovascularization in birdshot retinochoroidopathy.A 69-year-old black woman had ocular findings consistent with birdshot retinochoroidopathy; these included cream-colored depigmented spots at the level of the retinal pigment epithelium and vitreitis. She also had peripheral retinal neovascularization with localized vitreous hemorrhage. There were no laboratory or systemic findings consistent with other disease entities.- - - - - - - - - - ranking = 5keywords = neovascularization (Clic here for more details about this article) |
8/13. Subretinal choroidal neovascularization in birdshot retinochoroidopathy.We studied four eyes of two patients with bilateral birdshot retinochoroidopathy which developed subretinal choroidal neovascular membranes involving the macula. The subretinal choroidal neovascular membranes in our patients developed six months to five years after the onset of the disease. Both patients described decreasing visual acuities at the time when the choroidal neovascular membranes were identified. Adjacent to the classic depigmented areas of birdshot retinochoroidopathy were increased pigmentation, hemorrhage, or fluid indicative of subretinal neovascularization. fluorescein angiography confirmed the presence and demonstrated the location of these membranes.- - - - - - - - - - ranking = 5keywords = neovascularization (Clic here for more details about this article) |
9/13. Retinal vascular loss in idiopathic central serous chorioretinopathy with bullous retinal detachment.Three patients with idiopathic central serous chorioretinopathy (ICSC) and bullous retinal detachment (RD) were examined at least 2 years after the onset of the disease in one patient and over 10 years in the other two patients. There were large areas of retinal pigment epithelium (RPE) degeneration in each patient. Interestingly, there was loss of retinal vascular trees in the inferior peripheral retina where the subretinal fluid presumably persisted for a long time. In one patient, there was a retinal neovascularization with sea-fan formation along the border of the vascular loss. To the authors' knowledge, this finding has not been described in the literature.- - - - - - - - - - ranking = 1keywords = neovascularization (Clic here for more details about this article) |
10/13. Peripapillary subretinal neovascularization in chronic uveitis.Peripapillary subretinal neovascularization progressively developed in both eyes of a 17-year-old black woman with bilateral chronic granulomatous uveitis. Despite intensive medical therapy, central vision was lost in the left eye due to disciform scarring that extended to the macula. When a similar process was discovered in the right eye, argon laser therapy was started and was successful in eliminating all areas of subretinal neovascularization in the right eye while maintaining good cental vision. Chronic uveitis is probably another cause of peripapillary subretinal neovascularization, which can be treated with photocoagulation in spite of the presence of inflammation.- - - - - - - - - - ranking = 7keywords = neovascularization (Clic here for more details about this article) |
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