1/47. adenocarcinoma of the nonpigmented ciliary body epithelium: report of a rare case.Acquired tumours of the nonpigmented ciliary body epithelium are rare. We present herein a case of low-grade adenocarcinoma in order to stress the problems related to the clinical diagnosis. The tumour in our case was circumscribed, localised on the ciliary body, and nonpigmented. The height of the tumour, measured with ultrasound biomicroscopy, was 3.5 mm. The internal reflectivity of the tumor was homogeneous with low attenuation. The tumour was surgically excised with an uneventful iridocyclectomy. Both clinical presentation and preoperative examinations allowed to circumscribe the correct diagnosis which could be confirmed only with histology.- - - - - - - - - - ranking = 1keywords = adenocarcinoma, carcinoma (Clic here for more details about this article) |
2/47. indocyanine green iris angiography of lung carcinoma metastatic to the iris.BACKGROUND: To investigate the usefulness of indocyanine green (ICG) iris angiography for monitoring vascular abnormalities and the clinical course of metastatic iris tumor during chemotherapy. methods: We performed ICG iris angiography at several points during systemic chemotherapy for a 67-year-old man who had been diagnosed as having small-cell carcinoma of the lung with metastatic iris tumors. RESULTS: ICG iris angiography clearly demonstrated hyperfluorescent tumor vessels, rubeosis iridis, and dilated iris stromal vessels. After chemotherapy, these hyperfluorescent vessels and rubeosis regressed. CONCLUSION: ICG iris angiography appears to be an effective and useful method for observing abnormal vessels associated with metastatic iris tumors.- - - - - - - - - - ranking = 0.77506217698159keywords = carcinoma (Clic here for more details about this article) |
3/47. Fine-needle aspiration biopsy diagnosis of a uveal metastasis from a follicular thyroid carcinoma.PURPOSE: To report a rare tumour of the eye, and to illustrate the importance of performing a fine-needle aspiration biopsy. CASE REPORT: An 80-year-old woman suffering from general malaise, dyspnea and abdominal pain was found to have multiple lung metastases, a large tumour in the upper part of the mediastinum, and a large orange-brown tumour (19 x 15 x 11 mm) situated nasally in the left eye. Fine-needle aspiration biopsy of the uveal tumour and of the goitre was performed. Cytological examination from the two sites disclosed cells compatible with a follicular thyroid carcinoma of oxyfil cell-type. RESULTS: The patient underwent a total thyroidectomy and has so far had 2 series of 131I therapy. Additionally, the eye tumour was treated locally with a 125I plaque, and three months later the tumour thickness had decreased from 11.0 to 6.4 mm. Best-corrected visual acuity is still unchanged. The patient's general state improved as her dyspnea decreased significantly. CONCLUSION: The treatment has improved the patient's quality of life, and probably prolonged her life expectancy. Fine-needle aspiration biopsy was necessary to establish the diagnosis.- - - - - - - - - - ranking = 0.77506217698159keywords = carcinoma (Clic here for more details about this article) |
4/47. Anterior uveal and episcleral metastases from carcinoma of the breast.breast carcinoma is the most common primary tumor producing intraocular metastasis. Metastases to the iris and ciliary body are relatively rare. The authors report a case of a 61-year-old lady, operated for carcinoma of the left breast 3 years back, who presented with symptoms and signs of acute narrow-angle glaucoma in the right eye. A diffuse whitish plaque-like mass in the upper nasal quadrant of the iris with an episcleral nodule on the limbus in the corresponding area and all the signs of acute narrow-angle glaucoma were present in the right eye. intraocular pressure was controlled medically. Fine-needle aspiration cytology from the episcleral nodule showed malignant cells. Histopathology of the excised nodule showed metastatic poorly differentiated carcinoma, and the cellular pattern was similar to the carcinoma of the breast. There was no other metastasis anywhere in the body. Fine-needle aspiration cytology from an external lesion of the eye is a less invasive and easier procedure than paracentesis to diagnose the metastatic nature of the lesions. The rare features in our case are the clinical presentation as acute glaucoma and the ocular structures being the first and only site of metastasis.- - - - - - - - - - ranking = 1.2400994831705keywords = carcinoma (Clic here for more details about this article) |
5/47. Basaloid large cell lung carcinoma presenting concurrently with metastatic uveal tumor.A 51-year-old man complaining of cough, hemoptysis, and decreased visual acuity was admitted to our hospital. Chest radiography revealed a left hilar mass and pleural effusion in the left hemithorax. In his ophtalmological examination, there was total retinal detachment in the left eye. Ultrasonographic examination and orbital magnetic resonance imaging (MRI) were reported as choroidal metastasis. A computed tomography (CT) confirmed the mass in the left hilum and multiple mass lesions consistent with metastasis in the liver and in the body of 12th thoracic vertebra. Bronchoscopic biopsies revealed large cell carcinoma with basaloid features. He died after 4 months with rapid progression of the disease in spite of combined chemotherapy. Although primary lung cancer with concurrent eye metastasis is an uncommon entity, it should always be kept in mind for patients with ocular symptoms.- - - - - - - - - - ranking = 0.77506217698159keywords = carcinoma (Clic here for more details about this article) |
6/47. Metastatic adenocarcinoma of the prostate to the uvea as the initial presenting symptom in a 49-year-old man.We report a case of a 49-year-old man who presented with symptoms related to his right eye. Subsequent workup revealed carcinoma of the prostate metastatic to the uvea. On ophthalmologic evaluation, choroidal metastasis was noted. His prostate was firm on digital rectal examination, and the serum prostate-specific antigen level was 124 ng/mL. Prostate biopsy was consistent with adenocarcinoma, Gleason score 9. The patient was treated with total androgen blockade and radiation to the eye. Although his ocular lesions disappeared, the patient died of hormone-refractory disease 32 months after the diagnosis. The first case of prostate cancer metastatic to the uvea was reported more than 1 century ago; however, only a few cases have been reported subsequently. To our knowledge, we present the first published report in the urological literature of a patient in whom ocular complaints were the presenting symptoms that led to the diagnosis of prostate cancer. The urologist should be cognizant of the distinct possibility of ocular metastasis if a patient with prostate cancer presents with complaints related to the eye.- - - - - - - - - - ranking = 2.05476372747keywords = adenocarcinoma, carcinoma (Clic here for more details about this article) |
7/47. adenocarcinoma of the nonpigmented ciliary epithelium: report of two cases with immunohistochemical findings.BACKGROUND: Acquired neoplasms arising from the nonpigmented ciliary epithelium (NPCE) are much less common than uveal melanocytic proliferations. We report two cases of acquired neoplasms arising from the NPCE with immunohistochemical findings. methods: case reports. RESULTS AND CONCLUSIONS: Patient 1 was a 39-year-old man who presented with a pigmented mass behind the iris and secondary exudative retinal detachment. The eye also developed neovascular glaucoma. Patient 2 was a 44-year-old woman with a ciliary body mass but without symptoms. Both of these tumors were classified histologically as low-grade adenocarcinomas of the NPCE from specimens successfully removed by iridocyclectomy. Immunohistochemical findings confirmed the origin of the tumor cells; however, some changes in the immunoreactivity to cytokeratin AE1 and epithelial membrane antigen were found.- - - - - - - - - - ranking = 1keywords = adenocarcinoma, carcinoma (Clic here for more details about this article) |
8/47. Pleomorphic adenocarcinoma of the ciliary epithelium: a clinicopathological, immunohistochemical, ultrastructural, dna-ploidy and comparative genomic hybridization analysis of an unusual case.PURPOSE: To describe detailed phenotypic and genotypic analysis of a pleomorphic adenocarcinoma of the ciliary epithelium (CE). CASE REPORT: An 86-year-old white woman developed an enlarging mass protruding from her previously eviscerated left eye 2 months postoperatively. Based on light and ultrastructural microscopy, the final diagnosis was a pleomorphic adenocarcinoma of the ciliary epithelium (CE). DISCUSSION: cell proliferation indices confirmed the unusually rapid growth rate of this tumor; the peridiploid dna content might explain the relatively low incidence of distant metastases. An imbalance of the chromosome 6 was also found by comparative genomic hybridization (CGH).- - - - - - - - - - ranking = 2.2797015504884keywords = adenocarcinoma, carcinoma (Clic here for more details about this article) |
9/47. Neuroepithelial adenocarcinoma of the eye.A 29-year-old male patient with a microphthalmos on the right side since birth was seen in June 1987 in the University eye Clinic because of a massive exophthalmus of the former microphthalmic eye. Computer tomography revealed a diffuse, infiltrating tumor of the right orbit. The bulbus was not demarcated, and the whole orbita had to be eviscerated. Histologically, we found a solid, undifferentiated tumor with clear signs of malignancy. It consisted of epithelial cells, partly in nest formation, which were keratin positive and vimentin negative, and of more spindle-shaped formations which were keratin negative and vimentin positive. In some areas, the tumor showed a tubular or an adenoid proliferation. CEA or S-100 could not be demonstrated. The histopathological diagnosis was neuroepithelial adenocarcinoma of the eye. The differential diagnosis and the genesis of the tumor are discussed.- - - - - - - - - - ranking = 1.8997512920736keywords = adenocarcinoma, carcinoma (Clic here for more details about this article) |
10/47. Clinical efficacy of 123I-IMP SPECT for the diagnosis of malignant uveal melanoma.The diagnostic significance of several radiopharmaceuticals for malignant uveal melanoma has been discussed in the past decade. In our study, 99 patients with clinically suspected malignant uveal melanoma were considered; 36 had been treated and 63 were untreated. Single-photon emission computed tomography (SPECT) images were obtained after the intravenous injection of N-isopropyl- p-[(123)I]iodoamphetamine ((123)I-IMP). In the 63 patients without prior treatment, 36 were negative on (123)I-IMP SPECT, and all 36 except for 1, were histologically or clinically confirmed as having other, benign, entities including choroidal nevus, choroidal hemangioma, metastatic choroidal tumor, and other intraocular conditions. Twenty-seven of the 63 patients showed significantly high accumulation of (123)I-IMP in the late phase in the area corresponding to the intraocular lesion; all except 2 of these 27 patients were histopathologically or clinically confirmed as having malignant uveal melanoma. One of these 2 (123)I-IMP-positive patients was histologically diagnosed with adenocarcinoma arising from the pigment epithelium of the ciliary body. The 36 patients who had undergone eye-preserving treatments such as brachytherapy showed various results on (123)I-IMP SPECT. We concluded that (123)I-IMP SPECT is useful for the diagnosis of malignant uveal melanoma, especially in patients with atypical clinical manifestations for which conventional diagnostic techniques are inadequate to arrive at a definitive diagnosis.- - - - - - - - - - ranking = 0.37995025841473keywords = adenocarcinoma, carcinoma (Clic here for more details about this article) |
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