1/21. lymphomatoid granulomatosis in a child with acute lymphatic leukemia in remission.lymphomatoid granulomatosis, a tumor-like process of unknown etiology, produced progressively destructive disease of the larynx, trachea and bronchi in an eight-year-old girl with acute lymphoblastic leukemia of five years duration. The leukemia had been in remission for 4 1/2 years at the clinical onset of the lymphomatoid granulomatosis. Whether this occurrence suggests that lymphomatoid granulomatosis is a type of neoplasm, or is associated with immunologic depression, cannot be stated. Fortunately rare, and of poor prognosis, the disorder may become more frequent with improved survival rate of patients with leukemia and other neoplasms.- - - - - - - - - - ranking = 1keywords = neoplasm (Clic here for more details about this article) |
2/21. Juvenile neutrophilic eccrine hidradenitis: a vasculitis-like plantar dermatosis.Neutrophilic eccrine hidradenitis is a variety of neutrophilic dermatosis described in patients with different neoplasms, most often leukaemia, and different chemotherapy regimens. It is characterised by neutrophilic infiltration of the eccrine coils of sweat glands. Recently it has been described in healthy juveniles, involving primarily the soles of the feet. We describe five new cases of juvenile neutrophilic eccrine hidradenitis all showing a good prognosis or a self-limiting course.- - - - - - - - - - ranking = 0.5keywords = neoplasm (Clic here for more details about this article) |
3/21. Concomitant intramyocardial and epicardial vasculitis in an autopsied heart allograft for cardiac rhabdomyosarcoma.Primary cardiac tumours are rare, with only one quarter of the patients being malignant. The vast majority of malignant neoplasms of the heart are sarcomas. We describe a patient of primary cardiac rhabdomyosarcoma presented as coronary artery disease and recurrent myocardial infarction. Histopathologic finding of the excised native heart revealed a high grade pleomorphic rhabdomyosarcoma in the myoepicardial portion of the anterior wall with rupture. The accompanying unusual feature was myocardial infarction because of tumour emboli of the left anterior descending and left circumflex coronary arteries. After transplantation, the patient developed mild to moderate acute cellular rejection of the transplanted heart on post-transplantation day 1, 8, and 44, respectively. Unfortunately, he expired on the post-transplantation day 47 because of acute rejection, presenting as concomitant intramyocardial and epicardial lymphocytic vasculitis and multifocal myocardial ischaemia. We found that this uncommon medial lymphocytic vasculitis lesion was mediated by T cells and also by antibody directly against smooth muscle cells of small arteries. The consequence of such immune response would be compromised myocardial oxygenation resulting in allograft failure.- - - - - - - - - - ranking = 0.5keywords = neoplasm (Clic here for more details about this article) |
4/21. Late-stage nodular erythema elevatum diutinum.erythema elevatum diutinum (EED) is a rare chronic vasculitic process of unknown etiology that presents as bilateral, symmetrical, periarticular, red-brown papules and plaques, often over dorsa of joints. Early histologic changes are characterized by leukocytoclastic vasculitis. With chronicity, the lesions develop dense neutrophilic infiltrate and fibrosis. We describe an unusual case of late-stage nodular EED present for 35 years in a seronegative 75-year-old man. Asymptomatic papules and plaques measuring from 0.7 to 9.0 cm were seen over the interphalangeal joints, elbows, knees, and ankles. The histologic findings were characterized by predominant concentric fibrosis that formed well-circumscribed dermal and subcutaneous nodules. awareness of this unusual presentation of EED helps to avoid misdiagnosis as cutaneous neoplasms.- - - - - - - - - - ranking = 0.5keywords = neoplasm (Clic here for more details about this article) |
5/21. Paraneoplastic vasculitis associated with multiple myeloma.The association between vasculitis and cancer has been widely reviewed in recent decades. The existence of malignancies in patients with vasculitis has been estimated at about 4.5-8%, haematological neoplasms being the most frequently observed. The haematological malignancies most frequently described are lymphoproliferative diseases such as hairy cell leukaemia and lymphomas. On the contrary, the incidence of paraneoplastic vasculitis in patients with myeloma is low; up to now, we have found nine cases reported on this subject. We report the case of a 73-year-old woman who in 1 year showed three outbreaks of acutely painful, purpuric and ulceronecrotic lesions, localized on the lower extremities. Histopathological study demonstrated thrombosis in the arterioles and leucocytoclastic vasculitis. Complementary tests revealed the presence of multiple myeloma.- - - - - - - - - - ranking = 0.5keywords = neoplasm (Clic here for more details about this article) |
6/21. carbimazole induced eosinophilic granulomatous vasculitis localized to the stomach.Vasculitis associated with anti-neutrophil cytoplasmic antibodies has been reported in patients treated with anti-thyroid drugs and especially propylthiouracil. We report here a case of granulomatous eosinophilic vasculitis mimicking gastric neoplasm and peripheral eosinophilia in a 27-year-old man who was treated with carbimazole for 5 months for Graves' disease. Clinical and morphologic features resolved within 2 months after stopping the drug, suggesting a causative role for the drug. To our knowledge, this is the first biopsy-proven granulomatous eosinophilic vasculitis associated with this drug.- - - - - - - - - - ranking = 0.5keywords = neoplasm (Clic here for more details about this article) |
7/21. Primary angiosarcoma of the lung.Primary angiosarcoma of the lung is a rare disorder with few cases reported in the literature [Patel AM, Ryu JH. Angiosarcoma in the lung. Chest 1993;103:1531-35]. We present a case of primary angiosarcoma of the lung in a 79-year-old woman. Preoperative computed tomographic scan revealed soft tissue nodules surrounded by a halo of ground-glass attenuation, an appearance consistent with hemorrhagic pulmonary nodules [Primack S, Hartman T, Lee KS. Pulmonary nodules and the CT halo sign. radiology 1994;190:513-15]. lung biopsy revealed a multifocal malignant neoplasm with areas of hemorrhage. The histologic, cytologic, and immunophenotypic features were characteristic of epithelioid angiosarcoma. This case report contributes to the sparse literature on this disease and provides computed tomographic and pathologic correlation in a patient with hemorrhagic pulmonary nodules.- - - - - - - - - - ranking = 0.5keywords = neoplasm (Clic here for more details about this article) |
8/21. Testicular vasculitis mimicking a testicular neoplasm.Vasculitis of the testis generally presents as a manifestation of systemic vasculitis which is well documented. In isolation, it has only been described on few occasions previously, and hitherto it has been in the young. It often mimics a neoplasm of the testis resulting in radical orchidectomy, only for it to be diagnosed when the specimen is examined under the microscope. In our case, an elderly man presented to us with a presumed testicular neoplasm, however, despite strong clinical and radiological suspicion a testicular vasculitis in isolation was revealed. Following our experience, we performed a literature review and examined all of the cases of testicular vasculitis reported so far and present our findings. We report the general clinical presentation, methods of investigation and subsequent management. This is the first time it has been described in the elderly population.- - - - - - - - - - ranking = 3keywords = neoplasm (Clic here for more details about this article) |
9/21. Sonographic appearance of isolated necrotizing vasculitis of the testis.The presentation of necrotizing vasculitis of the testis is variable and may mimic a testicular tumor. Necrotizing vasculitis of the testis is characterized by fibrinoid necrosis of the walls of small and medium-sized testicular arteries. We report a patient with isolated necrotizing vasculitis of the testis who presented with clinical imaging findings suspicious for testicular neoplasm. We describe the clinical course and sonographic characteristics of evolving necrotizing vasculitis of the testis, briefly review the literature, and discuss the implications for the diagnosis and management of this condition.- - - - - - - - - - ranking = 0.5keywords = neoplasm (Clic here for more details about this article) |
10/21. muir-torre syndrome associated with alpha 1-antitrypsin deficiency and cutaneous vasculitis. Report of a case with exacerbation of a cutaneous neoplasm during immunosuppressive therapy.We describe a patient with both muir-torre syndrome and alpha 1-antitrypsin deficiency. A keratoacanthoma developed after immunosuppressive therapy for necrotizing vasculitis. To our knowledge, this is the first reported case of muir-torre syndrome associated with alpha 1-antitrypsin deficiency.- - - - - - - - - - ranking = 2keywords = neoplasm (Clic here for more details about this article) |
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