1/6. Intracranial haemorrhage due to vitamin k deficiency following gastroenteritis in an infant.Breastfed infants who are not given supplemental vitamin K after birth may develop vitamin k deficiency following gastroenteritis. Severe intracranial haemorrhage may occur.- - - - - - - - - - ranking = 1keywords = intracranial haemorrhage, haemorrhage (Clic here for more details about this article) |
2/6. vitamin k deficiency and bleeding after long-term use of cholestyramine.Although it has been long known that in theory the use of cholestyramine can cause coagulopathy due to reduced absorption of vitamin K, only a few cases have been reported. In those cases the coagulopathy occurred within a few weeks to months after the start of therapy. We report a patient with severe pruritus due to intrahepatic cholestasis, who was on cholestyramine therapy for over 25 years before haemorrhage occurred. This case demonstrates that one should be aware of the possibility of depletion of fat-soluble vitamins during the long-term use of cholestyramine.- - - - - - - - - - ranking = 0.065874274396304keywords = haemorrhage (Clic here for more details about this article) |
3/6. brain haemorrhage in five infants with coagulopathy.Most intracranial haemorrhages in infants after the neonatal period are secondary to non-accidental injury. Occasionally brain haemorrhages in non-mobile infants are due to an inherited coagulopathy. This may often be diagnosed with a coagulation screen on admission. Little is known about the neurological outcome of infants in the latter group. Five infants are described who presented with acute spontaneous brain haemorrhage secondary to an inherited coagulopathy (n = 3) and vitamin k deficiency in alpha(1) antitrypsin deficiency (n = 1) and Alagille's syndrome (n = 1). Despite the critical clinical presentation and the severe imaging findings, these five infants made a good neurological recovery. Infants presenting with spontaneous ICH due to a significant (inherited) coagulopathy are usually easy to differentiate from non-accidental shaking injury; their bleeding pattern within the brain seems different from non-accidental shaking injury and neurodevelopment outcome appears better.- - - - - - - - - - ranking = 1.1317870850032keywords = intracranial haemorrhage, haemorrhage, brain (Clic here for more details about this article) |
4/6. Acute infantile thrombocytosis and vitamin k deficiency associated with intracranial haemorrhage.A 5-week-old breast-fed girl presented unconscious and convulsing with heavily blood-stained CSF under increased pressure. This was associated with oozing from venepuncture sites, a grossly prolonged prothrombin time, and a raised platelet count. The prothrombin time became normal 18 hours after she had been given parenteral vitamin K and a transfusion of fresh plasma and red cells, but the thrombocytosis persisted. A moderate communicating hydrocephalus also remained and was treated, and one year later health and development appeared normal. The thrombocytosis resolved after a few weeks and has not recurred.- - - - - - - - - - ranking = 2.9460116096591keywords = intracranial haemorrhage, haemorrhage (Clic here for more details about this article) |
5/6. Fatal cerebellar haemorrhage due to phenprocoumon poisoning.A 32-year-old patient died of a cerebellar haemorrhage and the blood coagulation analysis before death suggested defective synthesis of vitamin K-dependent clotting factors due to vitamin k deficiency. The post-mortem toxicological examination of different tissues revealed phenprocoumon poisoning as the cause of death. The differential diagnosis of vitamin k deficiency and the toxicology of hydroxycoumarins are discussed.- - - - - - - - - - ranking = 0.32937137198152keywords = haemorrhage (Clic here for more details about this article) |
6/6. Thymic cyst haemorrhages and transient cholestasis in a 4-week-old infant.We report a 4-week-old boy with acute respiratory distress, due to massive haemorrhages in multiple thymic cysts. A right hemithymectomy was performed because of mechanical obstruction of the trachea by the cysts. The origin of the multilocular thymic cysts remained unclear. Most likely, these haemorrhages were caused by vitamin k deficiency, although the infant received vitamin K prophylaxis. In addition, he developed transient cholestasis, but the aetiology remained unclear. It is postulated that massive haemorrhages in thymic cysts produce large amounts of bilirubin, causing sludging of bile excretions in the liver. Four weeks after the operation, all laboratory findings were normal and 6 months after the operation the boy is still healthy. CONCLUSION: This case report shows that respiratory distress in an infant can be caused by multiple haemorrhages in multilocular thymic cysts.- - - - - - - - - - ranking = 0.52699419517044keywords = haemorrhage (Clic here for more details about this article) |