1/10. Schmidt's syndrome in a Saudi family.We present 3 patients from a Saudi family who are presented with polyglandular autoimmune syndrome type 2. They have Addison's disease with either autoimmune thyroid disease or insulin dependent diabetic mellitus. Although this syndrome is rare, the incidence among saudi arabia or the Arab population is not known.- - - - - - - - - - ranking = 1keywords = mellitus (Clic here for more details about this article) |
2/10. Idiopathic heart block: association with vitiligo, thyroid disease, pernicious anaemia, and diabetes mellitus.Out of 100 patients with chronic heart block 16 had one or more autoimmune disorders-namely, vitiligo (5,) hypothyroidism (4), Graves's disease (1), pernicious anaemia (2), and diabetes mellitus (9). All these disorders occurred with greater frequency than normal and were more prevalent than in a group of hospital inpatients of comparable age. autoantibodies were not increased. We suggest that among patients with idiopathic heart block there is a subgroup with multiple autoimmune disorders.- - - - - - - - - - ranking = 28.776092819202keywords = diabetes mellitus, mellitus, diabetes (Clic here for more details about this article) |
3/10. autoimmune diseases in a Nigerian woman--a case report.autoimmune diseases (AD) are conditions in which there is the development of antibodies against self cells/ organs. AD could either be organ-specific or non-organ specific (systemic) in clinical presentation. Commonly reported ADs includes: myasthenia gravis, Hashimoto thyroiditis, Guillian-Barre syndrome, vitiligo, type 1 diabetes mellitus, Graves diseases, Goodpastures syndrome, pemphigus, rheumatoid arthritis, systemic lupus erythematosis, Addisons disease, multiple sclerosis, pernicious anaemia, autoimmune haemolytic anaemia, chronic active hepatitis, idiopathic thrombocytopenic purpura. There is paucity of locally documented information on the occurrence of AD in same patient in our environment. We therefore report the case of a 66 year old woman who presented at the University College Hospital (UCH), Ibadan, with a spectrum of the AD, vitiligo, rheumatoid arthritis, myasthenia gravis, impaired glucose tolerance.- - - - - - - - - - ranking = 5.7552185638405keywords = diabetes mellitus, mellitus, diabetes (Clic here for more details about this article) |
4/10. Ulcerated disseminated cutaneous leishmaniasis associated with vitiligo, hypothyroidism, and diabetes mellitus in a patient with down syndrome.We report a 35-year-old man who was referred to our dermatology department with multiple, nodular, ulcerated, and crusted lesions disseminated on the face, trunk, and extremities. He has a known diagnosis of down syndrome. The past medical history also included vitiligo (for 20 years), hypothyroidism (for 2 years), and type-II diabetes mellitus (for 3 months). Direct smear of an ulcer was positive for leishmania. skin biopsy confirmed the diagnosis. A leishmanin skin test was negative. polymerase chain reaction (PCR) from two separate skin biopsies demonstrated the presence of leishmania major. To our knowledge, this is the first report of disseminated cutaneous leishmaniasis (DCL) caused by L. major in iran, and also the first report of association between DCL with down syndrome, vitiligo, hypothyroidism, and diabetes mellitus.- - - - - - - - - - ranking = 34.531311383043keywords = diabetes mellitus, mellitus, diabetes (Clic here for more details about this article) |
5/10. Slowly progressive type 1 diabetes mellitus associated with vitiligo vulgaris, chronic thyroiditis, and pernicious anemia.A 81-year-old woman was diagnosed as having diabetes mellitus (DM) at 58 years of age. She started insulin therapy the following year, but her blood sugar levels were poorly controlled. At the age of 75, she tested positive for the anti-GAD antibody (7.8 U/ml) and was diagnosed as having slowly progressive type 1 DM (SPIDDM), as well as vitiligo vulgaris. At 78 years of age, chronic thyroiditis was diagnosed after positive tests for anti-thyroid peroxidase antibody and anti-thyroglobulin antibody. At the age of 81, general fatigue and jaundice appeared concomitantly with severe anemia, with Hb levels at 5.2 g/dl. Low serum vitamin B12 levels and the finding of erythroblastic hyperplasia with megaloblasts in bone marrow led to the diagnosis of pernicious anemia. anemia was alleviated by intramuscular injections of vitamin B12. The patient developed chronic thyroiditis, vitiligo vulgaris, and pernicious anemia concomitantly with SPIDDM, and was diagnosed as having polyglandular autoimmune syndrome type III. attention should be paid to these potentially associated autoimmune diseases in daily practice during the follow-up of SPIDDM patients.- - - - - - - - - - ranking = 28.776092819202keywords = diabetes mellitus, mellitus, diabetes (Clic here for more details about this article) |
6/10. Schmidt's syndrome: a rare cause of puberty menorrhagia.Schmidt's syndrome, also known as polyglandular deficiency syndrome, is the presence of Addison's disease and hypothyrodism in a single patient. It is usually associated with other autoimmune disorders like vitiligo, diabetes mellitus, myasthenia gravis. A rare case of an 18-year-old girl having Schmidt's syndrome and vitiligo who presented with puberty menorrhagia is reported. A brief review of the literature is also given.- - - - - - - - - - ranking = 5.7552185638405keywords = diabetes mellitus, mellitus, diabetes (Clic here for more details about this article) |
7/10. Pernicious anemia, vitiligo and positive antiglobulin test: an unusual association.The authors present the case of a patient with concomitant pernicious anemia and positive antiglobulin test. After discussing previous cases in the literature and pointing out the probably simultaneous occurrence of the two, the authors comment on the persistence of a positive antiglobulin test after remission of the pernicious anemia and the association with vitiligo, which has been sometimes described as associated with autoimmune hemolytic anemia and more often with pernicious anemia, but not with both. The patient also had diabetes mellitus and a persistently false positive test for syphilis.- - - - - - - - - - ranking = 5.7552185638405keywords = diabetes mellitus, mellitus, diabetes (Clic here for more details about this article) |
8/10. vitiligo and polyglandular autoimmune endocrinopathy.vitiligo is probably an autoimmune disorder of the skin and is commonly associated with a number of known autoimmune endocrinopathies. We present a patient with vitiligo associated with diabetes mellitus and autoimmune thyroid disease. Further, we present evidence that vitiligo and autoimmune disorders coexist and discuss the interrelationship between vitiligo and autoimmune endocrine disorders.- - - - - - - - - - ranking = 5.7552185638405keywords = diabetes mellitus, mellitus, diabetes (Clic here for more details about this article) |
9/10. A syndrome of immunoglobulin a deficiency, diabetes mellitus, malabsorption, a common HLA haplotype. Immunologic and genetic studies of forty-three family members.Three persons in a kindred of 43 had variable expression of a syndrome consisting of immunoglobulin a deficiency, diabetes mellitus, malabsorption, and a common HLA haplotype. Findings from the proband included life-threatening malabsorption; idiopathic intestinal mucosal atrophy with infalmmation; iga deficiency and antibodies to multiple endocrine organs; insulin-dependent diabetes mellitus; and the major histocomptability antigens HLA-A2, B8, and DW3. In addition to the described syndrome other conditions present in the family include Graves' disease, vitiligo, hypocomplementemia, rheumatic fever, multiple sclerosis, and a high frequency of antibodies to endocrine tissue. Since Graves' disease, diabetes mellitus, and idiopathic Addison's disease have all been described in association with HLS-B8 and DW3, we believe that the occurrence of these diseases in this family suggests that a single immune response gene or gene complex is linked with HLA-B8 and DW3.- - - - - - - - - - ranking = 40.286529946883keywords = diabetes mellitus, mellitus, diabetes (Clic here for more details about this article) |
10/10. Linkage analysis in a large kindred with autosomal dominant transmission of polyglandular autoimmune disease type II (Schmidt syndrome).Schmidt syndrome (PGA syndrome type II) is a rare condition characterized by polyglandular failure. It is an autosomal dominant trait with variable expressivity that was inherited over four generations in an the indiana kindred. association of HLA-B8 has been reported with Schmidt syndrome. Our proband is a 12-year-old boy with addison disease, insulin dependent diabetes mellitus (IDDM), and vitiligo. Two of his eight sibs had either IDDM (sister) or vitiligo and hyperthyroidism (brother). His mother had hypothyroidism. Seven members of earlier generations apparently were also affected. We obtained peripheral blood for HLA and genetic analysis from 21 relatives in a family with 8 Schmidt syndrome individuals in three generations. HLA studies on 15 affected and unaffected relatives showed only 2 of 7 persons with B8-containing haplotypes. Therefore, no association exists between the B8-containing haplotype and the syndrome. We identified informative marker loci. No evidence for linkage of the Schmidt locus to any of the 14 markers was found and close linkage to esterase D and adenylate kinase and possibly properdin factor B was excluded.- - - - - - - - - - ranking = 5.7552185638405keywords = diabetes mellitus, mellitus, diabetes (Clic here for more details about this article) |
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