1/5. A case of giant congenital nevocytic nevus with neurotization and onset of vitiligo.The authors report the case of a 21-year-old woman with a giant congenital nevocytic nevus (GCNN) who developed vitiligo at the age of 16 years on skin areas remote from the GCNN. This is the first reported case of GCNN developing neurotization combined with vitiliginous changes within the GCNN lesion. Treatment with PUVA achieved repigmentation of the vitiligo lesions, except for the hypochromic areas within the area of the nevus that were shielded from UVA radiation.- - - - - - - - - - ranking = 1keywords = giant (Clic here for more details about this article) |
2/5. Permanent restoration of human skin treated with cultured epithelium grafting--wound healing by stem cell based tissue engineering--.The technique of epidermal cell culture developed by Green and colleagues made a breakthrough in the treatment of massive wounds in vivo with grown cells in vitro. In the past two decades, progress of culture methods and clinical practice have been made and now it is possible to treat extensive skin defect with large amounts of cultured epithelium. Since 1985, we have been successfully used cultured epidermis as autografts for the permanent coverage of full-thickness burn wounds or excised burn scars, giant nevi, tattoos and so on. Furthermore, cultured epidermis has been available as allografts to promote the healing of chronic skin ulcers or deep dermal burn. In this paper we describe our clinical experience of cultured epithelium grafting for the treatment of wounds and predict new trial of wound management and regeneration based on tissue engineering concept.- - - - - - - - - - ranking = 0.2keywords = giant (Clic here for more details about this article) |
3/5. Cafe au lait has hue of its own.Segmental pigmentation disorder is a pigmentation disorder (hypo- or hyperpigmentation) first described some 20 years ago. It appears early in life, is segmental, and usually has a sharp border in the midline. It can be confused clinically and histologically with several pigmentary disorders, especially with giant or segmental cafe-au-lait macules. The purpose of this article is to promote, revive, and refresh this somewhat neglected entity, and to further subdivide it into two types: segmental pigmentation disorder simplex and segmental cafe-au-lait. We illustrate our contention with case reports.- - - - - - - - - - ranking = 0.2keywords = giant (Clic here for more details about this article) |
4/5. Giant melanin granules in vitiliginous achromia with malignant melanoma.Histological and ultrastructural examination of normal and perilesional skin of a patient with vitiliginous depigmentation associated with a malignant melanoma revealed the presence of giant melanin granules in keratinocytes and melanocytes. These structures are compared to macromelanosomes which have been observed in numerous pigmentary diseases. The formation and significance of the giant melanin granules is discussed.- - - - - - - - - - ranking = 0.4keywords = giant (Clic here for more details about this article) |
5/5. orbital myositis, vitiligo, and giant cell myocarditis.Giant cell myocarditis is a rare idiopathic inflammatory heart disease characterized histologically by multinucleated giant cells, and clinically by rapid progressive heart failure, arrhythmias, or sudden death, often within hours to days of initial symptoms. There are two previously reported cases of giant cell myocarditis with idiopathic orbital myositis. We report a similar case in a patient who also had vitiligo, a diagnostic endomyocardial biopsy, and survival because of a cardiac transplant. Giant cell myocarditis should be monitored for in the course of inflammatory orbital myopathy because of its life-threatening fulminant course.- - - - - - - - - - ranking = 1.2keywords = giant (Clic here for more details about this article) |