1/4. Giant cutaneous horn associated with verruca vulgaris.Cutaneous horn (cornu cutaneum) is the clinical description of a hyperproliferation of compact keratin in response to a wide array of underlying benign and malignant pathologic changes. We report a patient with a giant cutaneous horn associated with a verruca vulgaris. The possible causes of cutaneous horns are reviewed.- - - - - - - - - - ranking = 1keywords = giant (Clic here for more details about this article) |
2/4. Giant verruca vulgaris.BACKGROUND: Common warts (verrucae vulgares) are hyperkeratotic papulonodules that are most often seen on the hands, arms, and legs, but they can be seen anywhere on the glabrous skin. Common warts represent the most frequent clinical lesions produced by the human papillomavirus (HPV). OBJECTIVE: Although they are diagnosed easily, giant, chronic, isolated, solitary, recalcitrant verruca vulgaris involving nail and nail bed on the digits can be misdiagnosed, and the differential diagnosis should be made carefully and verified by biopsies. METHOD: A 50-year-old male patient had a giant periungual verruca vulgaris on his left second finger. It was present for 2 years, was unresponsive to any treatment modality, and was treated by surgical excision. RESULTS: After 18 months of follow-up, there was no evidence of recurrence, and both aesthetic and functional results were quite satisfactory. CONCLUSION: Lesions of long duration generally lose their characteristic histopathologic features, and HPV cannot be detected in these lesions by polymerase chain reaction. Therefore, multiple sections should be examined histopathologically, and extreme care should be taken in order to avoid misdiagnosis.- - - - - - - - - - ranking = 2keywords = giant (Clic here for more details about this article) |
3/4. An unusual wart-like skin lesion found in a renal allograft recipient.Immunosuppressed renal allograft recipients have an increased tendency to acquire warts. While studying such patients, we found a virus-induced, wart-like lesion that had an unusual histologic picture. light microscopic studies showed bizarre keratinocytes with cytoplasmic, juxtanuclear, giant, crescentic bodies and round, nuclear inclusions, By electron microscopy, the giant cytoplasmic bodies were found to be composed of tonofilaments, and the nuclear inclusions were found to be composed of papillomavirus-like particles in a filamentous matrix. Typical papillomavirus particles were observed in a wart extract by the negative-staining method. Although virus was abundant in infected cells, no structural viral antigens of the human papillomavirus (HPV) types 1, 2, 3, or 5 could be detected by immunofluorescence microscopy, indicating infection by HPV 4 or some other, as yet undescribed, HPV type.- - - - - - - - - - ranking = 2keywords = giant (Clic here for more details about this article) |
4/4. Giant verruca vulgaris presenting as a neurotrophic foot ulcer.The most common factor associated with neurotrophic ulcers is either a peripheral or central somesthetic deficit, such as may occur in peripheral neuropathies, myelodysplasia, syringomyelia, sciatic nerve injury, spinal cord injury, tabes dorsalis, and most commonly, in the peripheral neuropathy of diabetes. Distribution of the ulcers indicates a mechanical factor in development. Here, three patients with an unusual type of neurotrophic ulcer, giant neurotrophic verruca vulgaris, are presented.- - - - - - - - - - ranking = 1keywords = giant (Clic here for more details about this article) |