1/9. Severe regimen-related toxicity occurring in a patient with XYY syndrome receiving allogeneic peripheral blood stem cell transplantation.A 23-year-old man with chronic myelocytic leukemia (CML) in the first chronic phase underwent allogeneic peripheral blood stem cell transplantation (PBSCT) from his HLA-identical sibling. Pretransplant evaluations showed that he had a low risk of transplantation-related mortality and that the interval between the diagnosis of CML and PBSCT was only 6 months. However, he developed a variety of complications, including acute renal failure requiring hemodialysis, severe hepatic damage, hemorrhagic cystitis, and gastrointestinal hemorrhage leading to hypovolemic shock. Pathological examination of the colonic mucosa showed vascular endothelial damage and thrombotic lesions, leading to the diagnosis of thrombotic microangiopathy. Later, we found that he had the constitutional abnormality XYY. XYY syndrome is a frequent congenital abnormality, and mental disorders and congenital abnormalities of kidney and liver are common manifestations. Considering his clinical course, it was interesting that complications were severe in the organs which are frequently involved in cases of XYY syndrome. These organs may have poor function or poor reserves and may be more vulnerable to endothelial damage caused by high-dose cytotoxic chemotherapy. patients with XYY syndrome might have a high risk of transplantation-related mortality.- - - - - - - - - - ranking = 1keywords = leukemia (Clic here for more details about this article) |
2/9. Conditioning with targeted busulfan for autologous peripheral blood stem cells transplantation for acute myelogenous leukemia in an XYY male.We report herein a 19-year-old Japanese male with XYY syndrome who developed acute myelogenous leukemia. During three courses of cytotoxic chemotherapy, he suffered repeated hepatic and renal insufficiencies, possibly related to latent dysfunction from the XYY syndrome. The patient was treated with granulocyte colony-stimulating factor combined with etoposide, cytarabine, and busulfan (the latter adjusted to a targeting dose) followed by autologous peripheral blood stem cell transplantation. He had no severe regimen-related toxicities and is now free of leukemia.- - - - - - - - - - ranking = 6keywords = leukemia (Clic here for more details about this article) |
3/9. Acute lymphoblastic leukemia in an XYY male.A case of acute lymphoblastic leukemia (ALL) in a 16-year-old male with a 47,XYY karyotype is reported. This chromosome aneuploidy was found in both bone marrow (BM) cells and mitogen-stimulated lymphocytes. Immunologic profile of leukemic cells showed a null phenotype. To our knowledge, this is the fifth case reported in the literature.- - - - - - - - - - ranking = 5keywords = leukemia (Clic here for more details about this article) |
4/9. XYY syndrome and acute myeloblastic leukemia.A 69-year-old man with hypogonadism was found to have a 47,xyy karyotype. Clinical and laboratory data revealed acute nonlymphocytic leukemia (ANLL) of the M2 type. The association between the XYY and ANLL-M2 is most likely accidental coincidence.- - - - - - - - - - ranking = 5keywords = leukemia (Clic here for more details about this article) |
5/9. Acute nonlymphocytic leukemia with a translocation (1;3)(p36;q21) in an XYY man.Neoplastic disease is quite rare in an XYY syndrome. We report the fifth known case, who suffered from acute nonlymphocytic leukemia (ANLL). Cytogenetic study of his bone marrow revealed a new chromosomal translocation (1;3)(q36;q21), which has only recently been described in patients with myelodysplastic syndrome.- - - - - - - - - - ranking = 5keywords = leukemia (Clic here for more details about this article) |
6/9. Chronic myelogenous leukemia with a complex Ph1 translocation in an XYY male.We encountered a 38-year-old Japanese male patient with chronic myelogenous leukemia (CML), whose bone marrow and peripheral blood cells during the chronic and blastic phases contained a complex Ph1 translocation and an extra y chromosome [i.e., 47,XYY,t(9;22;13)(q34;q11;q14)]. A karyotypic analysis of PHA-stimulated lymphocytes showed the constitutional karyotype to be 47,XYY. Thus, it was considered that CML with a complex Ph1 translocation developed in an XYY male; such a case has not been reported, so far. A B-lymphocyte cell line with the complex Ph1 translocation was established by the procedure of Epstein-Barr virus transformation. The presence of the complex Ph1 translocation in the B-lymphocyte cell line suggests that some of the B lymphocytes in this patient originated from the CML clone.- - - - - - - - - - ranking = 5keywords = leukemia (Clic here for more details about this article) |
7/9. Chronic myelogenous leukemia in an XYY male.Neoplasia has rarely been reported in the XYY syndrome. We report a patient with chronic myelogenous leukemia (CML), which comprises the third instance of malignancy reported in this disorder.- - - - - - - - - - ranking = 5keywords = leukemia (Clic here for more details about this article) |
8/9. Acute myelomonocytic leukemia in a XYY man.A case of acute myeloid leukemia (M4) in a 29-year-old male with a 47,xyy karyotype is reported. This aneuploidy was found in both bone marrow cells and mitogen-stimulated lymphocytes. monosomy 7 correlated with myelodysplastic features. The possible role of XYY in increasing the risk of leukemia is discussed.- - - - - - - - - - ranking = 6keywords = leukemia (Clic here for more details about this article) |
9/9. 47,xyy karyotype in acute myeloid leukemia.A case of acute myelomonocytic leukemia (AMMoL; M4) with a 47,xyy karyotype is reported. This chromosome aneuploidy was found in both bone marrow cells and mitogen-stimulated lymphocytes. The contribution of XYY chromosomal constitution in the pathogenesis of AMMoL is controversial.- - - - - - - - - - ranking = 5keywords = leukemia (Clic here for more details about this article) |