1/21. Xanthogranulomatous cholecystitis associated with a xanthogranulomatous pseudotumour on the left diaphragm.We present a case of xanthogranulomatous cholecystitis associated with a xanthogranulomatous vegetation on the left diaphragm with breakthrough into the thoracic cavity. A similar case has not previously been reported.- - - - - - - - - - ranking = 1keywords = cavity (Clic here for more details about this article) |
2/21. A giant verruciform xanthoma.BACKGROUND: Verruciform xanthoma (VX) is a rare, benign neoplasm arising predominantly in the oral cavity, but it has been reported to occur on the genital skin and mucosa as well. VX has also been described in association with epidermal nevi and squamous cell carcinoma. Because of the clinical and histologic similarities between VX and condyloma acuminata, and a recent report of HPV 6 in association with VX, we investigated the role of human papilloma virus (HPV) in the development of this entity. methods: in situ hybridization and a nested PCR approach utilizing degenerate primers were utilized to establish whether HPV infection could be playing a role in the development of the VX. RESULTS: in situ hybridization failed to identify HPV dna. The highly sensitive nested PCR approach also failed to detect HPV dna. CONCLUSIONS: The failure to detect HPV dna, even by very sensitive methods, provides strong evidence that our case of VX is not an HPV-induced lesion. A review of other possible etiologies, including alternative infectious agents and genetic associations, are discussed.- - - - - - - - - - ranking = 25.556440545045keywords = oral cavity, cavity (Clic here for more details about this article) |
3/21. Xanthogranulomatous cystitis.Xanthogranulomatous cystitis (XC) is a rare benign chronic inflammatory disease of unknown etiology. Herein we report a case of a 70-year-old woman who presented with frequent, postmicturition pain and lower abdominal discomfort. cystoscopy revealed a mass at the dome of the bladder near the left wall. Enhanced computed tomography (CT) demonstrated a mass with a central cavity. The patient underwent partial cystectomy because the presence of bladder neoplasm could not be ruled out. She had has no recurrence of XC 29 months after the operation. The present case of XC is the 20th to be reported in the world.- - - - - - - - - - ranking = 1keywords = cavity (Clic here for more details about this article) |
4/21. Verruciform xanthoma in association with discoid lupus erythematosus.Verruciform xanthoma (VX) is an uncommon lesion occurring primarily in the oral cavity. Cutaneous lesions are much less common and they preferentially arise on anogenital skin. They are not necessarily associated with a pre-existing inflammatory process. We report a VX in association with a long-standing lesion of discoid lupus erythematosus (DLE) on the scalp of a 34-year-old black woman. This association, which to our knowledge has not been previously reported, is consistent with the proposed pathogenetic mechanism of entrapment and subsequent degeneration of epithelial cells in the papillary dermis of VX. Histological distinction of VX from squamous cell carcinoma, with which this lesion may be clinically confused, is straightforward.- - - - - - - - - - ranking = 25.556440545045keywords = oral cavity, cavity (Clic here for more details about this article) |
5/21. Verruciform xanthoma of the oral cavity: clinicopathological study relating to pathogenesis. Report of three cases.Verruciform xanthoma is a rare condition that was first reported in the oral cavity in 1971. Its histopathology is distinctive on account of the presence of foamy histiocytes within elongated dermal papillae. Three cases of oral mucosal verruciform xanthoma were studied. Immunohistochemical staining by streptavidin-peroxidase and in situ hybridization to detect human papillomavirus (HPV types 6, 11, 16, 18) dna and matrix metalloproteinase (MMP-2, -9) rna were performed to investigate the pathogenesis of verruciform xanthoma. This study showed that the foam cells were strongly positive for CD68 (KP1) and vimentin. Cytokeratin, PCNA and S-100 stained focally negative in foam cells. in situ hybridization failed to detect HPV (types 6, 11, 16, 18) in any of the three cases. Based on our findings we conclude that verruciform xanthoma is most likely not a human papillomavirus-associated lesion; the foam cells, as a histological hallmark of the lesion, are most likely derived from the monocyte-macrophage lineage, and verruciform xanthoma is, at least partly, mediated by an immune mechanism. MMPs degrade basilar membrane that promotes the reciprocal induction between epithelium and mesenchyme. However, as yet unrecognized factors may play a role in the development of epithelium-mesenchyme reciprocal induction.- - - - - - - - - - ranking = 127.78220272522keywords = oral cavity, cavity (Clic here for more details about this article) |
6/21. Lethal outcome in xanthogranulomatous endometritis.Xanthogranulomatous inflammation is rare, mainly involving the kidneys, while primary xanthogranulomatous endometritis (XE) is a very unusual finding, histologically characterized by partial or complete replacement of the mucosa by granulation tissue with an abundance of foamy histiocytes, siderophages and multinucleated giant cells. We present the case of a 69-year-old woman with a short history of abdominal pain and a palpable mass in the pouch of Douglas. dilatation of the cervix drained a pyometra. Histological examination of the curettage rendered the diagnosis of XE. Microbiological studies revealed enterococcus spp. and peptostreptococcus magnus. Despite antibiotic treatment the patient died of heart failure due to systemic inflammation. autopsy confirmed the diagnosis of XE with transmural extension into the peritoneal cavity. Such a lethal course of XE is extraordinary. Proposed causes of XE include obstruction, infection and hemorrhage. Demonstration of enterococcus spp. and P. magnus supports the probable significance of bacteria in the development of XE. Because this condition may mimic malignant disease macroscopically and histologically, knowledge of XE is of major importance for both pathologists and gynecologists.- - - - - - - - - - ranking = 1keywords = cavity (Clic here for more details about this article) |
7/21. Multiple intracranial xanthogranulomas--case report.A 58-year-old female was admitted to our hospital with nausea, vomiting, and gait disturbance of 1 year duration. Postcontrast computed tomographic scans demonstrated enhanced lesions in the left cerebellopontine angle (CPA), the retrosellar region, the right parasellar region, and the left parietooccipital convexity. The left parieto-occipital tumor was totally removed in the first operation and the left CPA tumor was partially removed in the second. The histological diagnosis of both tumors was xanthogranuloma. She also had cutaneous lesions (subcutaneous nodules without tenderness) and an ureteral stenosis possibly due to the retroperitoneal involvement. A skin biopsy demonstrated infiltration of xanthoma cells and foamy cells in the dermis. A gallium scintigram demonstrated an abnormal uptake in the thoracic cavity, liver, and bones. From these findings, systemic Weber-Christian disease was diagnosed. Another unique aspect was that the serum IgE levels were increased during postoperative hospitalization. This suggests that abnormal immunological conditions are related to this disease and that intracranial xanthogranulomas are a manifestation of systemic Weber-Christian disease.- - - - - - - - - - ranking = 1keywords = cavity (Clic here for more details about this article) |
8/21. Intrathoracic xanthoma mimicking lung cancer in a patient with familial hypercholesterolemia type II: a case report.Xanthomas are benign soft-tissue lesions commonly occurring on the skin, subcutis, or tendon sheaths of patients. The lung and thoracic cavity is a rare location for xanthomas. We present a 39-year-old woman who was admitted to our hospital with complaints of dyspnea, cough, and chest pain. She had a prior diagnosis of type II familial hypercholesterolemia. Chest x-ray film and computed tomography scans revealed a large tumor-like mass in the right hemithorax. Thoracal mass and narrowed tracheal segments were removed using cardiopulmonary bypass. Histopathologic findings were consistent with xanthoma.- - - - - - - - - - ranking = 1keywords = cavity (Clic here for more details about this article) |
9/21. Verruciform xanthoma of the vulva: case report.A rare case of verruciform xanthoma of the vulva is reported. diagnosis was made possible by histopathological examination and immunohistochemical staining. Verruciform xanthomas generally occur in the oral cavity. To the best of our knowledge, this is the third reported case of the tumour located on the genital mucosa. Immunohistochemical study supported the histiocytic origin of the lesion. Clinically, verruciform xanthomas may mimic other verrucous lesions of the vulva, such as seborrhoeic keratosis, verruca simplex, condyloma acuminatum, verrucous carcinoma, or erythropasia of Queyrat, or conditions such as histiocytosis, cutaneous lipidosis, or granular cell myoblastoma. The characteristics that differentiate those conditions from verruciform xanthoma, which can be seen only on histology, are given.- - - - - - - - - - ranking = 25.556440545045keywords = oral cavity, cavity (Clic here for more details about this article) |
10/21. Necrotic pseudoxanthomatous nodules of ovary and peritoneum in endometriosis.The clinical and pathological features of four unusual cases of pelvic endometriosis are described. The patients, who were between the ages of 40 and 72 years, underwent operations for uterine leiomyomas in two cases, endometrial adenocarcinoma in a third case, and an enlarging abdominal mass in a fourth case. In three patients, two of whom had enlargement of one or both ovaries, multiple nodules were either attached to the peritoneum (two cases) or lay free in the peritoneal cavity (one case). In one of these cases, the intraoperative findings mimicked metastatic carcinoma. Histological examination of the peritoneal lesions, as well as the ovaries in all the cases, revealed granulomatous nodules composed of a central focus of necrotic tissue surrounded by histiocytes (pseudoxanthoma cells), hyalinized connective tissue, or both. Endometriotic glands and stroma were typically absent in the nodules and their immediate vicinity. Foci of recognizable endometriosis, however, were found in the ovaries in all the cases. In one of the ovaries, several necrotic nodules lined an endometriotic cyst; in another, a focus had an appearance transitional between endometriosis and a necrotic nodule. These necrotic pseudoxanthomatous nodules are a previously undescribed manifestation of endometriosis; they occur characteristically in older women. On histologic examination, they should be distinguished from other necrotic peritoneal and ovarian granulomas, as well as necrotic tumor.- - - - - - - - - - ranking = 1keywords = cavity (Clic here for more details about this article) |
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