Does anyone have information about the misdiagnosis of Lambert-Eaton myasthenic syndrome (LEMS)?

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I know this is more of a medical question but since it is a rare disease few physicians have adequate answers. I am hoping to receive information from others that might have been diagnosed. A relative of mine was told she had LEMS based on her symptoms and tests of her muscles. After a recent blood test, however, she was told she was negative for LEMS.
I don't have a CLUE! But since no one else has answered this, you might want to consider either reposting this question or just googling it!  (+ info)

What is the difference between Eaton Lambert Syndrome and Myasthenia Gravis?

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I see they both have many similarities but what is the major difference? I am doing a case study with a patient who was diagnosed with both, which is one of only 6 cases known.
That's kinda complex! You're quite right in that Eaton-Lambert and MG both have similar features - they usually manifest as weakness, either of limb muscles or eye movements, although MG more frequently affects the eyes.

MG is auto-immune, and has a characteristic antibody that can be detected in the blood (anti-cholinesterase), whereas Eaton-Lambert does not. The electromyogram findings can be similar in that they both show reduction in the muscle potential with repeat stimulation at low frequencies - the difference in Eaton-Lambert is that with high frequency stimulation, the potentials classically will INCREASE.

One other thing to note is that Eaton-Lambert is often associated with the presence of cancer - it's one of the 'paraneoplastic' syndromes.  (+ info)

Would like to hear from anyone that has the Lambert Eaton Muscle Syndrome?

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I would suspect that these details are known by you, but I add them in case there any details that you are not familiar with, Lambert-Eaton syndrome (myasthenic syndrome – LEMS) is a disorder with symptoms very similar to those of myasthenia gravis. There is muscle weakness associated with disturbed communication between nerves and muscles. In myasthenia gravis, the neurotransmitter acetylcholine (the chemical that transmits impulses between nerves and muscles) is blocked by antibodies to its receptor. In Lambert-Eaton syndrome, however, the signal distortion is caused by an insufficient release of neurotransmitter by the nerve cell. As muscle contraction is continued, the amount of neurotransmitter may build up in sufficient quantities and result in increased strength. The disorder may be associated with small-cell carcinoma of the lung and other malignancies as a paraneoplastic syndrome or with autoimmune disorders.
For more information, contact either of the following –

The Muscular Dystrophy Association
National Headquarters
3300 E. Sunrise Drive
Tucson, AZ 85718
(800) 572-1717
www.mda.org


NIH Neurological Institute
P.O. Box 5801
Bethesda, MD 20824
Phone: (800) 352-9424
www.ninds.nih.gov


Hope this helps
Matador 89  (+ info)

Looking for anyone who has been diagnosed with a condition, called LEMS, or Lambert Eaton Mysania Syndrome?

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What is Lambert-Eaton Myasthenic Syndrome?
Lambert-Eaton myasthenic syndrome (LEMS) is a disorder of the neuromuscular junction-the site where nerve cells meet muscle cells and help activate the muscles. It is caused by a disruption of electrical impulses between these nerve and muscle cells. LEMS is an autoimmune condition; in such disorders the immune system, which normally protects the body from foreign organisms, mistakenly attacks the body's own tissues. The disruption of electrical impulses is associated with antibodies produced as a consequence of this autoimmunity. Symptoms include muscle weakness, a tingling sensation in the affected areas, fatigue, and dry mouth. LEMS is closely associated with cancer, in particular small cell lung cancer. More than half the individuals diagnosed with LEMS also develop small cell lung cancer. LEMS may appear up to 3 years before cancer is diagnosed.



For more info on treatment, etc. go to web site
ninds.nih.gov/disorders/lambert_eaton/lambert_eaton.htm  (+ info)

does anyone know someone who has Lambert Eaton syndrome?

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i can help you with some answers  (+ info)

What is the name of the syndrome that the person may appear to have facial characteristics of down's syndrome?

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I previously watched a documentary about sufferers of a syndrome whose facial features appeared to be down's syndrome but it wasn't down's syndrome. The grow to be quite large adults and have special needs. Does anyone know the name of this condition?
Klinefelter syndrome  (+ info)

Are there different types of Down syndrome and what areas of the body does Down syndrome affect? ?

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Also, are there any significant statistics related to Down syndrome? Has Down syndrome received any recent attention from the media? Are there any famous people that have Down syndrome.
Answer as many of the above questions as possible.
There are three types of Down syndrome, garden variety Trisomy 21, mosaicism and translocation.

Read more at:

Welcoming Babies with Down Syndrome (English, Spanish, French)
http://www.bellaonline.com/articles/art32534.asp

There is a slide show that also incorporates videos of the featured 'More Alike than Different' cast at the National Down Syndrome Congress website:

http://www.ndsccenter.org/morealike/flash/

And great information at the National Down Syndrome Society website:
Down Syndrome Fact Sheet
http://www.ndss.org/index.php?option=com_content&view=category&id=35&Itemid=57

You might also enjoy

Margaret's Guide to Down Syndrome
http://www.patriciaebauer.com/2007/05/12/margarets-guide-to-down-syndrome/

For bios of actors with Down syndrome, see:

Down Syndrome and the Acting Gene
http://www.bellaonline.com/articles/art34198.asp

and

DS in Arts and Media
http://www.dsiam.org/

and

Michael Johnson
http://www.users.psln.com/sharing/Michael/mainMichael.html

and

Sujeet Desai
http://www.sujeet.com

Down Syndrome Links at the Family Village website
http://www.familyvillage.wisc.edu/lib_down.htm

Check out this recent New York Times article:

The DNA Age: Prenatal Test Puts Down Syndrome in Hard Focus
http://www.nytimes.com/2007/05/09/us/09down.html

Have fun with your research!
  (+ info)

What is so bad about having down syndrome?

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I think people are a lot colder than they want you to believe. Too many pregnancies prediagnosed with down syndrome are terminated! Doctors tell people that their kid will be like some animal and people believe them. I've met my share of people with down syndrome, and they all seem pretty human to me. On top of that, they were all decent folks, which is a lot more than I can say for the general population. And how does knowing that unborn children are purged because of down syndrome affect those who were born and have down syndrome?
WOW!! I'm so glad that there are other people who's lives have been touched as mine has. See when I was 28 I gave birth to twin girls and one of them was born with Mosaic down syndrome. Of course, I didn't know much about it til now....and yes I was shocked. They are 14 months old now, and such a blessing as well as my two boys. My daughter is about 4 months behind in her milestones, but she is always so happy! Out of all my kids she is the easiest to handle.

It's always nice to have other people, who see that they are more alike, then different from the rest of us.  (+ info)

What is the syndrome called when you cannot feel physical pain?

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I remember watching a show a long time ago, and this one little girl was born with a syndrome where she could never feel pain. If she fell on the floor and cut her knee, she wouldn't cry, whereas most children would.

What is this called? Is it a syndrome? Is it a medical condition? I just want to know what it's called, and I can do the research on it.

It is for a story I am writing but I don't entirely know what it is.
It's called "congenital insensitivity to pain"  (+ info)

What syndrome would someone have that the doctor would need to put them on bloodthinners?

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My sister is 18 and just moved out here from MN to go to school. She has had many medical problems and been to several doctors. She recently told me that the doctor said there was something wrong with her blood and she needs to be put on blood thinners for the rest of her life. What syndrome could this be?
There are several, but the first that comes to mind is Factor-V (five).  (+ info)

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