Why do people with Sickle Cell Anaemia suffer from leg ulcers?

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and why are they also found in other haemolytic anaemia's?
Sickle cell anemia is caused by an abnormal type of hemoglobin called hemoglobin S. Hemoglobin is a protein inside red blood cells that carries oxygen. Hemoglobin S, however, distorts the red blood cells' shape. The fragile, sickle-shaped cells deliver less oxygen to the body's tissues, and can break into pieces that disrupt blood flow.
Hemolytic crisis occurs when damaged red blood cells break down. Hence sickle cell anemia patients suffer from hemolytic anemia.
Leg ulcers
This usually occurs on the lower part of the leg. They happen more often in males than in females and usually appear from 10 through 50 years of age. The cause of leg ulcers is unclear.  (+ info)

there is an ointment called 'placengell' made in Switzerland for the treatment of leg ulcers can you find it?

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It was available some years ago from a firm in switzerland but they changed their address and now we cannot find them can you help?
I did a google search for placengel but all I could find were the links below. I hope you find them of some use.  (+ info)

what are some treatments for leg edema and ulcers?

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I was diagnosed with incompetent leg vein valves and I get edema in my legs and sometimes ulcers,I absolutely hate compression socks/hose because they are hot and itchy and I found that wrapping an ice bandage from the toe to knee is the same damn thing,I take over the counter supplements called Venastat but that doesn't seem to be helping is there any other treatments I can try?
  (+ info)

How to self cure ulcers on a leg?

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They are about 2 inches circular, center tough, itchy, purplish looking, not leaking any fluid, not responding to ointments from dermitolgoist
I do have bad cirulation, the doc gave me bactroban cream, mupirocin ointment, and something else, I used each one at a different time, not all at once. Also I'm on toprol XL 50mg and Nexium, Gluocaime something from the chiro and vitamins
We need more info. Are you diabetic or do you have decreased circulation in your legs? Do you have any calf pain while walking or any pain associated with these lesions? What ointments has the dermatologist had you use? What other medications are you on? Do you keep your body clean in general? Do they smell? Does the skin around these lesions look normal or is there any discoloration, either around the lesions or to the entire leg? Do you have any allergies? Dude, need the info before trying to help you.  (+ info)

How long does a bleeding ulcer surgery take to recover from?

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I have a bleeding ulcer and have been advised to have surgery. I need to know how long I will be layed up?
19 agonising weeks.  (+ info)

How do you treat a chronic foot ulcer that is Sickle Cell related?

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The Ulcer is abt 2cms across and has been on the foot joint on the exterior side. Its been a year since it formed. No signs of healing despite use of Bactroban & daily cleaning using water only at home.
The patient needs to see a wound care specialist as soon as possible.

Wounds should not persist for a year, even on someone with sickle cell disease.

In fact, someone with sickle cell disease should be treated more aggressively that a non-sickle cell person.

Year long use of Bactroban will cause the Staph on the skin (MRSA or non-MRSA) to become resistant to the antibiotic. In addition, using just water to keep it wet can slow down the growth of new tissue, preventing healing.

The real danger here is not so much Staph bacteria, other organisms can take hold like Pseudomonas aeruginosa.

2 centimeters is a fairly large wound to be around for a year. You may need some debridement of the area, special wound care and some of the newer wound packing materials to stimulate new skin growth.

Good luck!  (+ info)

What are the symptoms of a stomach ulcer?

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What is the difference between the symptoms of a stomach ulcer and not just an upset stomach or indigestion?
Well usually vomiting up blood,blood in your stools. They are black in colour. When you are vomiting up blood. It looks like coffee grounds. Hope this as been of some help  (+ info)

How long does it take for a stomahc ulcer to destroy your stomach?

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In other words, how long does it take before a stomach ulcer completely perforates your stomach? Amazing how I can't find this on google...
It totally depends on the circumstances. It could get eroded away quickly by bacteria, it could be eroded quickly by alcohol or NSAIDs like aspirin and ibuprofen, stomach acid, etc. It depends on if its being treated. Too many variables to determine a timeframe in general. Every case would be different.  (+ info)

How does nervousness and stress cause someone to have a duodenal ulcer?

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Dave is under a lot of stress at his job and at home. He begins to feel disconfort and a burning sensation in his abdomen following a meal. After consulting a doctor, he finds that he has developed a duodenal ulcer. He does not understand how being nervous would cause the ulcer and asks us to explan.
When the body or mind is under stress it can stimulate the stomach to produce more acid - after a while this eats through the mucous lining and causes an ulcer. I thought that most ulcers were caused by a bacteria - heliobacter pylorus - has he been checked for that?  (+ info)

How can you get rid of a stomach ulcer quickly?

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I have one that has been making me vomit all the next day after I drink. No matter what I drink or how much. It is miserable. I want to be able to enjoy some drinks every now and then but this stomach ulcer just won't allow it. Any suggestions on how to get rid of it?
First things first - With all due respects, there is no such thing as bland diet for ulcers. This age old notion of giving a low-fiber diet based on bland foods such as milk, toast, crackers, poached white fish etc. has long been since discredited as no therapeutic benefits from it were reported. Instead, now the emphasis is on letting people with ulcers eat a normal diet and judge for themselves if certain specific foods cause them trouble. These then could be isolated form the diet and rest continued. In fact, very general and continued alteration of the diet will obviously lead to many deficiencies (of essential nutrients) as it is only a well balance diet that provides your body not only with proteins, fats, carbohydrates but also nearly all the essential nutrients (minerals and vitamins) so badly needed by you for the efficient functioning of all the vital organs.

http://www.healthherbsandnutrition.com/remedies/p/pepticulcer.htm

Your doctor may prescribe antibiotics to kill the bacteria and proton pump inhibitors or histamine receptor blockers to prevent the stomach from producing too much acid. If H.pylori is detected, then a course of antibiotics together with a drug that protects the stomach lining and prevents too much acid production is called triple therapy.

However, these medications can bring about some harsh side effects such as diarrhea, headaches, dizziness, nausea and interfere with liver function. In men, certain side effects of medication may lead to breast enlargement and impotence. In some cases, surgery may also be required.

Fortunately, herbal and homeopathic remedies can safely and effectively prevent the recurrence of ulcers and other digestive disorders. A well known herb for digestive health is Matricaria recutita, (German Chamomile) which contains anti-inflammatory, anti-spasmodic and calming properties.

Other herbal ingredients such as Filipendula ulmaria and Ulmus fulva are extremely effective in reducing pain and irritation while also protecting the digestive tract and reducing stomach acid secretions. In addition, Sutherlandia frutescens has been used for thousands of years to treat chronic and acute digestive complaints and also acts as a potent tonic.  (+ info)

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