What is the basis of differing actions of antineoplastic agents on different tissue/neoplasms?

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What is the basis for differing tissue- and neoplasm-specificites of antieoplastic chemotherapeutic agents? This doubt arose because considering what the pharmacokinetics of these drugs are it remains to be answered as to why a certain agent would act only in a particular tissue or neoplasm when the mechanisms they employ are so similar, e.g., various alkylating agents in spite having same action act of different tumors with differing degrees of effectiveness. Hope someone answers the question specifically. Useful links to free-text articles would also be highly appreciated. Bye. TC.
If you have thoughts on this subject, you ought to have the initiative to research it yourself.  (+ info)

What types of tissue in humans are vascular? what types are avascular?

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vascular means it has blood supply.

avascular means it does not.  (+ info)

Is connective tissue vascular?

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Is connective tissue vascular? How? Give an example

Please help!!
I have read your question very carefully and I felt the frustration of not being able to ask you a few probing questions before answering. However, I would at the very least like to email you a few things to consider that will at least offer a few things to consider and may offer additional aspect for your consideration...with your permission first!


MD., 21 years
F.A.C.C.  (+ info)

What is meant by there is a large amount of soft in the tissue of the right femur?

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I had an MRI and report said "There is large amount of soft in the tissue with homogeneous suppression of fat. There was no abnormalities within the muscular, bony, or vascular structures." Can someone help me understand what they mean by a large amount of SOFT in the tissue?
I reread the report it says, "Ther is large amount of soft in the tissue with homogeneous suppression of fat. There is no abnormalities within the muscular, bony, or vascular structures.
It probably states soft tissue, not soft in the tissue.  (+ info)

What do you call a benign neoplasm arising from adipose tissue?

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What do you call a benign neoplasm arising from adipose tissue?
A fatty lipoma?  (+ info)

What is the connection between malignant neoplasms and crabs?

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The more common term for malignant neoplasms, cancer, is Latin for crab, and the word "carcinogen," meaning a cancer-causing agent, comes from the Greek word for crab, "karkinos." What is the connection between these two seemingly unrelated things?
Cancer, both the disease and the astronomical constellation, derive from the Latin cancer or cancrum, meaning crab. The astrological sign, of course, is said to resemble a crab and the disease was so named by the ancient Greek physician Galen (129-200 A.D.) who noted the similarity between a certain type of tumor with a crab as well—the swollen veins around the tumor resembling the legs of a crab.

Old English adopted cancer directly from Latin and used it for a variety of spreading sores and ulcers. This early sense survives in the modern word canker. From c.1000 in a manuscript called Læce Boc (Leech Book), collected in Oswald Cockayne’s Leechdoms, Wortcunning, and Starcraft of Early England, Vol. II, 1865:

Gemeng wið þam dustum, clæm on ðone cancer.
(Mix with the dust, smear on the cancer.)

And from Wyclif’s 2 Timothy, 1382:

The word of hem crepith as a kankir

The word was being applied specifically to the disease we today call cancer by the beginning of the 17th century. From Philemon Holland’s translation of Pliny’s Historie of the World:

Cancer is a swelling or sore comming of melancholy bloud, about which the veins appeare of a blacke or swert colour, spread in manner of a Creifish clees.

The astronomical sense of cancer is from the Latin name for the constellation of the crab. The name was known to the Anglo-Saxons, but only as a Latin name and was not assimilated into English until the Middle English period. It appears in Ælfric’s De Temporibus Anni, written c.993, in a list of the constellations of the Zodiac:

Feorða • Cancer • þæt is Crabba
(Fourth, Cancer, that is the crab.)

The Anglicized name appears c.1391 in Chaucer’s Treatise on the Astrolabe:

In this heved of cancer is the grettist declinacioun northward of the sonne...this signe of cancre is clepid the tropik of Somer.
(At this first point (head) of cancer is the greatest declination northward of the sun…this sign of cancer is named the tropic of summer.)

(Source: Oxford English Dictionary, 2nd Edition)  (+ info)

Does nicotine inhibit muscular tissue from absorbing oxygen?

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Please be specific in your response. If not what are the exact effects on the cardio vascular system?
YES! Basically, what happens is that carbon monoxide adheres to red blood cells better than carbon dioxide and oxygen, so when you smoke, your red blood cells dont carry the oxygen around as well as a non-smoker. Red blood cells are what carries oxygen around and removes any toxins from muscles and what have you.  (+ info)

How do vasoconstrictors relieve a vascular headache?

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A vascular headache is a headache where blood vessel swelling or disturbance causes the pain.

Vasoconstrictors are supposed to help, but I'm not sure why or how.
They narrow the blood vessels, slowing the blood flow.  (+ info)

How do I improve my cardio vascular fitness/endurance level? Any supplement can help?

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I know that exercise can improve cardio vascular fitness level but is there any supplement / medication that can raise it?
any supplement/medication that raises your cardio rate is BAD BAD BAD.

it would stress your system unnaturally.

Stick to the sweat and huff method. Run,jog, etc.  (+ info)

Do vascular problems in your leg have an impact on migraene headaches?

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I have severe Migraene hadaches for several days in the row. Now, I also have vascular problems in my left leg. Is there an research study of the these two symptoms which tricker the other?
This is the BEST Headache information.

Make the connection!

Being a nurse with over 25 years experience, I have seen a lot of people with various illnesses. Many allergic reaction are indeed caused from foods HOWEVER...many more are caused from chemicals and fragranced products as well as VOC's in homes, schools and workplace.

This is a growing problem and many people are not even aware that it exists as more and more chemicals are being introduced and used on a daily basis. Many people believe that because something smells good and it is on a store shelf that it is tested, approved and safe for use.
Think again !

We are now seeing more and more children and adults with Chronic Headaches, Sinusitis, Migraines, Chronic Sinus Infections, Asthma, Allergies, Hives, Eczema, sinus / respiratory illnesses and Hormone related disorders. I can not emphasize how important it is to educate yourself about MULTIPLE CHEMICAL SENSITIVITY (MCS) and the harm you may be doing to your health by using chemicals and fragranced products.

If you or a loved one has symptoms of or suffers from Asthma, Allergies, Autism, chronic headaches, reproductive problems, Migraines, Chronic Fatigue Syndrome, Lupus or Fibromyalgia, you need to read further and learn about the signs and symptoms of MCS - Multiple Chemical Sensitivity.

Most doctors will not inform you about this because patients as a whole like to walk out of a doctors office with a prescription for some magical medicine and they do not want to be told that their expensive new perfume or newly installed carpet may be the culprit. So, the doctor will give you medications and many of these meds either do not work or cause other health problems.

Chemicals and fragranced products are often the root of many disorders and illnesses when it comes to your health. Many of the below mentioned items are common triggers to sinus, asthma, itching, headaches, Migraines and allergy problems amongst other health issues. Get rid of them and your immune and respiratory system will thank you and you will breathe easier.

And, it is not only personal body or cleaning products causing havoc on your health….many people become ill after wearing brand new clothing, dry-cleaned clothes, installing new carpet, painting, buying a new mattress or after home renovations because of the Flame Retardants, Antimony, Benzenes, Formaldehydes, etc. used in these products. So the answer is NO, you are not imagining that 2 weeks after your home, office or classroom got renovated you started to become ill, get dizzy or have headaches. This is happening more and more these days and adults as well as children are becoming sicker and sicker.

Unfortunately, too many doctors compound the problem by prescribing chemical medications to try to alleviate the symptoms of an already chemical overloaded body and they rarely tell the patient to eliminate the chemical offenders. How many times have I seen people in the grocery store with Bounce, Glade Plug-Ins and Febreeze in their shopping cart along with a bottle of Benadryl , Migraine Excedrin and a box of Allergy Tablets ? Why don't they make the connection?

Keep in mind that your skin is the largest organ of your body and what you put on your skin gets absorbed into your body. Then ... well... then it has to be filtered by your organs which are already working real hard.

BIG NO-NO's ---- I would SERIOUSLY recommend removing all of the below from your living / working area.

No Bounce or dryer sheets - these are VERY toxic
No Febreeze - your pets will even thank you for this
No Glade Plug-ins - VERY toxic
No Scented candles
No Scented Dish Detergents
No Fragranced Products on Body, Hair or Clothing
No Smoke
No Newspapers and Magazines - The ink is a huge irritant.
No Dander
No Sprays
No Sharpies (marker pens)
New Cartpeting, mattresses, paint, contain toxins that can trigger severe respiratory disorders as well as headaches and Asthma flare-ups.
And remember, it is NOT the smell it is the Chemicals that make up the smell. So, even if something is "Fragrance Free" these products often mask the smell with another chemical ! There are plenty of safe healthy products out there that work well and do not have added chemical fragrances.

More and more workplaces & schools are implementing Fragrance Free policies and creating "Fragrance Free Zones"… why do you think this is? Make the connection, your lungs , immune system and your general health will thank you.  (+ info)

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