Can anyone help me out, what is the pathophysiology for systemic lupus erythematosus?
Systemic lupus erythematosus (SLE or lupus) is a chronic autoimmune disease that is potentially debilitating and sometimes fatal as the immune system attacks the body’s cells and tissue, resulting in inflammation and tissue damage. SLE can affect any part of the body, but most often harms the heart, joints, skin, lungs, blood vessels, liver, kidneys and nervous system. The course of the disease is unpredictable, with periods of illness (called flares) alternating with remission. Lupus can occur at any age, but is most common in women, particularly of non-Caucasian descent.[1] Lupus is treatable symptomatically, mainly with corticosteroids and immunosuppressants, though there is currently no cure.
Pathophysiology: Autoantibodies, circulating immune complexes, and T lymphocytes all contribute to the expression of disease. Organ systems affected include dermatologic, renal, central nervous system (CNS), hematologic, musculoskeletal, cardiovascular, pulmonary, the vascular endothelium, and gastrointestinal. The revised criteria for SLE must include 4 of the following at any time during a patient's history (specificity 95% and sensitivity 75%): (
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Systemic Lupus Erythematosus or Rheumatoid Arthritis?
My symptoms are: Extremely painful to walk, rashes, blood in urine, Anemia (had to get iron infusions), headaches, extreme fatigue, ect. I seen a doctor who did some x-rays, blood work & a physical exam. She recently called me & told me from my lab results came back & said i have either Systemic Lupus Erythematosus or Rheumatoid Arthritis. She said my blood work showed alot of abnormalities & even infection. She wanted me to start on a steroid right away. She put me on (10 mg pills of Prednisone) for 10 days until my follow up with a Rheumatologist. Okay my question: What is Lupus & Rheumatoid Arthritis?
Are these 2 illnesses simular? She will be calling me back within 5 days with the other test results. Has anyone personally experienced this? She said my illness is treatable but not cureable. I'm still pretty young & this is a shock to me & i'm having a hard time dealing with not knowing what i'm dealing with i guess my new doctor will be able to answer alot of questions later.
Thanks for the advice i will go look there.
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Lupus and RA are autoimmune diseases, that is when your immune system attacks your own cells.
These two diseases overlap in some people, so don't focus so much on an absolute diagnosis.
I am sorry that you have this problem. It sucks. Try to take the steroids as little as possible because, although it may help you feel better, it has lots of side effects over time.
Looking back over your symptoms, it sounds like you have something else going on too. Doctors do not know what causes the outbreak or auto-immune diseases. It can be stress, chemical exposure, diet or most commonly, something you can never identify.
Make sure you get good sleep. Eat a super healthy diet with plenty of vegetables and fruits.
My Mom had RA. I have friends with lupus and related illnesses. Don't give up hope. There are so many advances in the treatment of these diseases.
Here are a couple of links on auto-immune disease:
http://www.lef.org/protocols/immune_connective_joint/lupus_01.htm
http://www.lef.org/protocols/immune_connective_joint/rheumatoid_arthritis_01.htm (
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Systemic lupus erythematosus is a condition that sometimes affects young women. It is a .....?
chronic (persistant) inflammation that affects all or most of the connective tissue proper in the body. Suzy is told by her doctor that she has lupus, and she asks if it will have widespread or merely localized effects in the body. What do you think the doctor will answer and why?
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And the reason you are asking the same question over and over is???????????????? (
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is systemic lupus erythematosus caused by a specific genus or species?
why patients with SLE produce antibodies directed at components of their own cells?
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The cause of lupus is not clearly understood. It is not contagious, not cancerous, and not HIV/AIDS. What we know right now is that a person may be genetically predisposed (they have idenified numerous genes that are involved) and then a trigger or triggers turn the autoimmune switch on. There are many cases of genetically identical twins where one develops lupus and the other does not.
In lupus, the problem is that some cells of the immune system mistakenly identify healthy cell as invaders like viruses, bacteria, and fungi. Those cells send a message for other parts of the immune system to destroy whatever they have identified as bad. There is no cure for lupus. Lupus is currently controlled by suppressing or weakening the immune system. Earlier medications weakened the entire immune system. The new biologics weaken only specific parts. No new drug has been FDA approved for the treatment of lupus since November 20, 1958. (
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My mom has Lupus Erythematosus. Can she file for disability?
My mom is not only diabetic, but she has lupus. It's harder and harder for her to work full-time. Can she file for disability? If so, how?
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First of all, I'm sorry for your mom. My mom had Lupus also. Check with the social security office on applying for disability. I know my mom didn't qualify, but she never was able to work. (
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acute cutaneous lupus erythematosus is a skin desease how to protect ?
Take a look at this story written by one of our patients, hopefully it should answer a few questions for you: http://www.lupus.org.uk/patients/claire.htm
Also you can send questions to our lupus nurseonline who provides a free service: http://www.lupus.org.uk/onlinenurse.htm
Hope that helps. (
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Systemic Lupus Erythematosus?
Is Systemic Lupus Erythematosus a kind of cancer and is it fatal? If some one can help me out with this, I'd be glad. Thanks.
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Lupus (including SLE) is an autoimmune disease (a condition where your body's immune system attacks its own tissues and organs). The disease can be mild to severe; no two afflicted people are exactly alike. It is not considered a cancer. Yes, lupus can be fatal, but not as often as was in the past.
Read about lupus at http://www.mayoclinic.com/health/lupus/DS00115.
http://www.lupus.org.uk/article.php?i=196
http://www.medicinenet.com/systemic_lupus/article.htm
http://www.nlm.nih.gov/medlineplus/ency/article/000435.htm
My rheumatologist evaluated me for lupus several years ago. At that time I familiarized myself with the condition. (
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How can we cure Systemic Lupus Erythematosus? (SLE) - or known as Lupus diseases?
Will it worsen if someone with Lupus getting older?
If there's no cure, is there any known ways to fight this immune disease?
I heard of controlled diet can lead to a better life with Lupus, is that works?
Are there any certain foods that someone with Lupus cannot take? or maybe recommended to be taken?
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there is no cure. in lupus, your immune system attacks your own body for some reason, so its managed with immunosuppressant drugs to slow the progression of the disease. (
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Systemic lupus erythematosus?
Hello,
Does anyone know what the swelling in the lymph nodes is due to in patients with SLE?
One of my friends has SLE and as I am doing biology I'd like to know the reasons behind it.
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Lupus is an autoimmune disease. Our immune systems have trouble telling the difference between invaders like germs and viruses and our healthy body parts. As a result, we are more inclined to develop infections and have a hard time shaking them. That could cause the problem. We also make huge molecules called immune complexes which are a product of the autoimmune activity. Although these immune complexes should be dumped in the spleen to be processed, our immune systems fall down on that job too. They leave the immune complexes wherever they want. Most often (95%) it is in the joints, kidneys (40%) or any other place. This causes inflammation (swelling). Or the immune system could decide it doesn't like the lymph nodes, that they are invaders, and try to destroy them. More than likely it is a combination of all of the above. (
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Lupus Erythematosus?
I have been diagnosed with SLE: Systemic Lupus Erythematosus, but for the moment it remains cutaneous. What are the chances for the disease to spread and attack other tissues? And if that does happen, is there any medication that can prevent the disease from permanently damaging the organs?
I'm so scared, please help.
Once you have this disease, do you have it for life?
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In some patients with cutaneous lupus, it does also turn into systemic lupus. Most cases of systemic lupus are mild to moderate and are controlled by medication and lifestyle changes. The majority of people with systemic lupus will live a relatively normal life span if they follow their treatment regimen (90%+). You said you have been diagnosed with systemic lupus. That means it is more than cutaneous. Many patients have both.
The medications which control lupus are immunosuppressive drugs. Prednisone is the first line of defense in calming a flare, or period of disease activity. But prednisone can cause some problems at high doses and if taken for long periods of time. Most of us take hydroxychloroquine (Plaquenil) twice a day for life. This is preventive. For many patients the hydroxychloroquine is enough. If you have organ issues, then additional immunosuppressive drugs will be prescribed depending on what organ is involved.
Lifestyle choices that help are:
1. Eat a nutritious, balanced diet that is high in fruits and vegetables (at least 5 servings a day) and low in animal fat. Most of the time, avoid highly processed foods or fast food.
2. Get some physical exercise on a regular basis.
3. Learn stress management. Yoga, Tai Chi, meditation are all good tools.
4. Learn about lupus so you can better manage it.
5. Develop healthy and open communication with your physicians.
6. Follow your treatment regimen and don't be afraid to ask questions.
7. Talk to others with lupus. I am 56, have systemic lupus with organ involvement, and lead a very full and happy life. :-)
8. Stay out of the sun PERIOD!
There is no cure for lupus. You will have it for life. That said, you can learn to manage the lupus, work with your doctors and have a good life. Sure, it will be a little different from those who do not have lupus. You are the one who creates your new life with lupus. It is possible! (
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