FAQ - sertoli cell tumor
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My nephew had a brain tumor that went into his spine. It is cancerous. He is having stem cell tansplant.?


My brother and his wife are staying very optimistic. He is a young boy, 10 or 11. I am trying to get a grasp of what stage of the fight he is in. Does a stem cell transplant resemble a treatment of desperation? I am confused and don't want to ask too many questions as they are already so stressed out.
He has also gone through 2 rounds of chemo.
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Stem cell transplants are not used to treat brain tumors.  (+ info)

extragonadal germ cell tumor?


My brother was diagnosed with extragonadal germ cell tumor, can anyone explain to me what causes this and what can happen to him? will he die?
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95% of all testicular tumors are germ cell tumors. That is, the tumors originate in the sperm forming cells in the testicles (the males gonads) or egg producing cells in the ovary (female gonads). Occasionally, however, germ cell tumors develop elsewhere in the body without any evidence of cancer in the testes. When this happens they are referred to as Extragonadal Germ Cell Tumors (meaning outside of the gonads).

During embryonic development (when you are but a clump of cells), germ cells are first seen outside of the embryo in the yolk sac. At about 4 to 6 weeks of development, these cells migrate into the embryo where they populate the developing testes or ovaries. If these cells miss their destination, they are likely to come to rest in one of a number of midline sites in the body. Extragonadal tumors arise when these cells become cancerous. In some cases, however, an apparent extragonadal tumor turns out to be a metastatic testicular tumor where the primary tumor has "burnt out" or died on its own.

Extragonadal germ cell tumors can take on a variety of tumor types. They can be either benign (teratoma) or malignant. Malignant tumors can be either seminoma [aka germinoma in females] or nonseminoma (embryonal carcinoma, immature teratoma, endodermal sinus tumor [aka yolk sac tumor], choriocarcinoma, and mixed germ cell tumors). Although much more common in males, extragonadal tumors can also occur in females.

The great majority (80%) of these tumors are benign and are handled with surgery alone. Most of the benign tumors occur in children. While benign tumors occur with equal frequency in men and women, malignant extragonadal tumors are much more common in males (9:1). Understand this, though: extragonadal germ cell tumors are rare, accounting for only 1 to 4% of all germ cell tumors.

This type of cancer is aggressive and is usually seen in young adults. Patients with mediastinal nonseminomatous EGC are typically classed as poor risk patients because these cancers often have unusual biological features that diminish cure rates and add additional complexities to treatment. Despite these unusual characteristics, about half of even these patients are cured. Other extragonadal sites do not share these same adverse biological features and are usually classified with an intermediate prognosis. For all extragonadal seminomas, the outlook is identical to metastatic testicular seminomas with the same high prospect of cure.  (+ info)

What are the risks associated with post acinar cell tumour of pancreas?


My relative underwent a surgery for acinar cell tumor of pancreas in 2005. Now she is pregnant. Is it safe for her to have a baby? What are the risks involved and what would be the precautions required so as to ensure she lives for a very long period.
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There is no way to answer you. We do not even know the stage or her treatment. In general the prognosis for pancreatic cancer is not good. Although, acinar cell tumors have a better prognosis than adenocarcinomas. This is a very uncommon cancer and it is very unusual to occur in someone young enough to have children so there is little known about this combination and therefore, impossible to ensure a long life. She has already survived longer than the average person. I hope she stays this way.  (+ info)

Has anyone had a recurring Giant Cell Tumor?


7 years ago I had a Giant Cell tumor removed from my left knee but the doctor couldnt get all of the tumor because of the location. The last two weeks I have has quite a bit of pain and pressure in my knee(without injury) I was told there was a chance that it could grow back. Could that be the cause of my discomfort? I know I dont want to get the point I was last time. It was pretty painful
I have not had my tumor checked since post op. He never said to keep getting it checked. He said he had to hook it and rip it out. Which didnt sound all that great. Ive been surching on online, and according to what I have read there should have been more done to try and prevent it from recurring. I was told from its location it was to hard to get to w/ arthroscopic surgery and he did what he could. He didnt want to cut my knee open. I did make an appointment to speak with my physician.
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Yes it could be the cause of your discomfort. Have they been doing periodic CT scans to keep an eye on what was left of the tumor? I just had a giant cell tumor removed last week. But they told me if it caused by PVNS (which mine was) there is up to a 40% chance of reoccurance. I would see your doctor and have them do a MRI or CT to check.  (+ info)

I had a benign granular cell tumor removed during an endscopy...?


...is it necessary to have ANOTHER endoscopy 15 mos later to make sure granular cell tumor did not return or is it safe to assume a GCT doesnt grow back/was benign, etc...
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I dont know if it is necessary, but i would have another endscopy to be sure.  (+ info)

Can someone please tell me what Sertoli-cell-only syndrome is?


Many Thanks
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Sertoli cell-only syndrome also known as the Del Castillo syndrome and germ cell aplasia is a disorder causing male sterility without sexual abnormality (You have normal secondary male features and have normal or small sized testes) .
This is the result of absent seminiferous tubules in the testes of germinal epithelium with the Sertoli cells present
However your sperm may be viable but an injection into a testicle may allow you to artificially reproduce  (+ info)

Which of the following genes control cell specialization, replication, DNA repair, tumor suppression?


Option 1: Oncogenes
Option 2: Proto-oncogenes
Option 3: Regulatory genes
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2  (+ info)

I heard that radiation from cell phones can give you a brain tumor is that true?


A Swedish study finds that users of digital phones in rural areas may be at greater risk of brain cancer. Its authors say the link is troubling, although they acknowledge that the amount of data is small and wider research is needed to amplify the findings.

The researchers said that incidence of brain tumors in rural areas of Sweden was much higher among users of GSM cell phones than among rural residents who were not cell phone users. The rate was also higher than among GSM users in urban areas.

The chance of developing a malignant brain tumor was roughly eight times higher for cell phone users in the Swedish countryside than in urban areas. The risk of developing any brain tumor was four times higher for country dwellers using mobile phones for five years or more, compared with those who did not use the devices.

The study suggests that mobile handsets in rural areas deliver a higher dose of electromagnetic radiation because they have to transmit a stronger signal to distant transmission towers, whereas towers are closer together in urban areas, resulting in phones transmitting a weaker signal.

Researchers looked at more than 1,400 adults aged 20 to 80 who had been diagnosed with a malignant or benign brain tumor between 1997 and 2000. The brain cancer patients were compared with a similar number of healthy adults living in the same area. Each group was asked to recall their daily use of mobile and cordless phones.

"Clearly our results support the notion that exposure may differ between geographical areas," Hardell said. "But there is no information on the exact difference between geographical areas."  (+ info)

Hiya.. I'm still unable to use my leg properly after having a Giant Cell Tumor removed from my leg.?


I was hoping to talk to others who have suffered this tumor as it is very rare.. Ive been told it may grow back too..great!
Any feedback will be fantastic..
I had the operation done in Aug 2007 at stanmore..which was pretty grim also am on sick now due to it all
Thanks again peeps xx
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I am 29 and had one removed from my femur when I was 17. It was 6 inches long and there was only a thin wall around the sides and back. I was lucky not to break my leg. I actually am in the middle of writing a speech for a public speaking class and just looked it up to see if I found anything on Yahoo. I had to get x-rays for three years but the chance of it coming back are very slim. I am quite active. I run, bike, ski, and even went skydiving four times since my surgery. So I think you should be fine over time. The one thing is that I did not stick to good to the therapy and I wish I would have, because now my opposite leg became my dominate leg and I think working it out more would have been a wise plan. Anyway good luck and keep your head up.  (+ info)

What is the blood test to determine how much a tumor has shrunk during chemo?


My wife has to give blood for testing once a week to help the doctors determine how strong the chemo to put in her iv. Is there a specific test that shows if the tumor is shrinking? I know about the white and red cell count, but is there a "cancer" test? She has squamous cell of the lung, stage 2. No spreading of the cancer anywhere else, thank God.
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The CA125 bloodtest measures the level of cancer cells in the body. Your wife's blood is also being tested to see that her white blood count is high enough for her to have treatment. A low WBC will just delay her next cycle of chemo a bit. This is very common and there are now shots that can be given to correct this. Her blood will also be checked for her level of red cells to determine whether she might be anemic. Again, there are treatments for this also. Speak to your wife's oncologist so that he can better explain about the tests and the CA125 , which are probably being done on a regular basis. The results of the CA125 take longer to come back so you may have to keep asking the oncologist.  (+ info)

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