Transmembrane receptor for CLASS 3 semaphorins and several vascular endothelial growth factor isoforms. neuropilin-2 functions either as a homodimer or as a heterodimer with neuropilin-1. The binding affinity of neuropilin-2 varies for different class 3 semaphorin isoforms and is dependent on the composition of the dimer. The protein also forms receptor complexes with plexins and with VEGF RECEPTORS, which alters the binding characteristics of the receptor.