Cerebellar degeneration associated with a remote neoplasm. Clinical manifestations include progressive limb and gait ataxia; dysarthria; and nystagmus, pathologic. The histologic type of the associated neoplasm is usually carcinoma or lymphoma. Pathologically the cerebellar cortex and subcortical nuclei demonstrate diffuse degenerative changes. Anti-Purkinje cell antibodies (anti-Yo) are found in the serum of approximately 50% of affected individuals. (Adams et al., Principles of neurology, 6th ed, p686)


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