A TGF-beta subtype that was originally identified as a glioblastoma-derived factor which inhibits the antigen-dependent growth of both helper and CYTOTOXIC T lymphocytes. It is synthesized as a precursor molecule that is cleaved to form mature TGF-beta2 and TGF-beta2 latency-associated peptide. The association of the cleavage products results in the formation a latent protein which must be activated to bind its receptor.