Osteoarthritis, Spine; Lumbar Osteoarthritis; Spinal Osteoarthritis

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osteoarthritis; osteoarthritis, spine; spine

	Active principles	Rating	Bibliogr.
1	Glucosamine	100	+
2	Hyaluronic Acid	86	+
3	Matrix Metalloproteinase 13	75	+
4	Naproxen	72	+
5	Iodoacetates	71	+
6	Anthraquinones	58	+
7	Collagenases	57	+
8	Chondroitin Sulfates	56	+
9	Diclofenac	55	+
10	Etodolac	54	+
11	Piroxicam	54	+
12	Matrix Metalloproteinase 3	53	+
13	Acetaminophen	48	+
14	Aggrecans	46	+
15	Pyrazoles	45	+
16	Proteoglycans	43	+
17	Iodoacetic Acid	42	+
18	Collagen Type II	39	+
19	Sulfonamides	39	+
20	Glycosaminoglycans	38	+
21	Ibuprofen	35	+
22	Sulfones	35	+
23	Chondroitin	35	+
24	Lactones	34	+
25	Metalloproteases	30	+
26	Keratan Sulfate	29	+
27	Thiazines	28	+
28	Indoleacetic Acids	26	+
29	Metalloproteins	26	+
30	Metalloendopeptidases	25	+
31	Uronic Acids	24	+
32	Bromelains	24	+
33	Indoprofen	23	+
34	Organic Chemicals	23	+
35	Matrix Metalloproteinases	23	+
36	Interleukin-1beta	21	+
37	Matrilin Proteins	21	+
38	Plant Extracts	21	+
39	Matrix Metalloproteinase 1	21	+
40	Procollagen N-Endopeptidase	20	+
41	Cyclooxygenase 2	20	+
42	Microbial Collagenase	20	+
43	Phenylpropionates	19	+
44	Diphenylamine	19	+
45	Mineral Waters	18	+
46	Extracellular Matrix Proteins	18	+
47	Doxycycline	18	+
48	Calcium Pyrophosphate	18	+
49	Prostaglandin-Endoperoxide Synthases	18	+
50	Tramadol	18	+
51	Paraffin	17	+
52	Cartilage Oligomeric Matrix Protein	17	+
53	Propionates	16	+
54	Tissue Extracts	16	+
55	Triamcinolone	16	+
56	Alendronate	16	+
57	Tissue Inhibitor of Metalloproteinases	16	+
58	Methylprednisolone	15	+
59	Endopeptidases	15	+
60	Dinoprostone	15	+
61	Ketoprofen	15	+
62	Membrane Proteins	15	+
63	Polynucleotides	15	+
64	Etidronic Acid	15	+
65	S-Adenosylmethionine	14	+
66	Thiophenes	14	+
67	Adrenal Cortex Hormones	14	+
68	Collagen Type I	14	+
69	Pentosan Sulfuric Polyester	14	+
70	Plant Preparations	14	+
71	Collagen	14	+
72	Oxycodone	14	+
73	Interleukin-1	14	+
74	Cyclic Nucleotide Phosphodiesterases, Type 2	14	+
75	ADAM Proteins	14	+
76	Glycosides	13	+
77	Cathepsins	13	+
78	Cathepsin K	13	+
79	Isoenzymes	13	+
80	Interleukin 1 Receptor Antagonist Protein	13	+
81	Carbazoles	13	+
82	Glucocorticoids	12	+
83	Calcitonin	12	+
84	Tissue Inhibitor of Metalloproteinase-1	12	+
85	Glycoproteins	12	+
86	Pyrans	12	+
87	Rho Guanine Nucleotide Exchange Factors	12	+
88	Diphosphonates	12	+
89	Fenoprofen	12	+
90	Indenes	11	+
91	Indomethacin	11	+
92	Dimethyl Sulfoxide	11	+
93	Bone Cements	11	+
94	Sulfur	11	+
95	Receptors, Interleukin-1	11	+
96	Drugs, Chinese Herbal	11	+
97	Protein Hydrolysates	10	+
98	HLA-B39 Antigen	10	+
99	Cysteine Proteases	10	+
100	Hydroxyproline	10	+
101	Pyridines	10	+
102	Cyclooxygenase 1	10	+
103	Interleukin-1alpha	9	+
104	Phenylacetates	9	+
105	Thiazoles	9	+
106	Sodium Salicylate	9	+
107	Alkaline Phosphatase	9	+
108	Durapatite	9	+
109	Phenylbutyrates	9	+
110	Scopoletin	9	+
111	Sodium Radioisotopes	9	+
112	Bone Morphogenetic Protein 7	9	+
113	Flurbiprofen	9	+
114	Peptides	9	+
115	Calcium	9	+
116	Gelatinases	9	+
117	Salicylates	9	+
118	Tumor Necrosis Factor-alpha	8	+
119	RNA, Messenger	8	+
120	Triamcinolone Acetonide	8	+
121	Capsaicin	8	+
122	Steroids	8	+
123	Placental Extracts	8	+
124	Aspartame	8	+
125	Transforming Growth Factor beta	8	+
126	Sialoglycoproteins	8	+
127	Azirines	8	+
128	Bupivacaine	8	+
129	Folate Receptor 2	8	+
130	Phenylbutazone	7	+
131	Morphine	7	+
132	Receptor, Bradykinin B2	7	+
133	NF-kappa B	7	+
134	Tannins	7	+
135	Substance P	7	+
136	Curcumin	7	+
137	Chemokine CCL20	7	+
138	Diflunisal	7	+
139	Oxymorphone	7	+
140	Osteocalcin	7	+
141	Gold Compounds	7	+
142	Intercellular Signaling Peptides and Proteins	7	+
143	Aniline Compounds	7	+
144	Acetates	7	+
145	Waxes	7	+
146	Sulindac	7	+
147	Nitric Oxide	7	+
148	Acetylglucosamine	7	+
149	Phenols	7	+
150	Matrix Metalloproteinase 2	7	+
151	Thrombospondin 1	7	+
152	Organometallic Compounds	7	+
153	Matrix Metalloproteinase 9	7	+
154	Stigmasterol	7	+
155	Receptors, Urokinase Plasminogen Activator	6	+
156	Isoxazoles	6	+
157	Peptide Hydrolases	6	+
158	Nitric Oxide Synthase Type II	6	+
159	Fursultiamin	6	+
160	Teriparatide	6	+
161	Tetracyclines	6	+
162	Peptide Fragments	6	+
163	Sulfates	6	+
164	Lidocaine	6	+
165	Matrix Metalloproteinases, Membrane-Associated	6	+
166	Tissue Inhibitor of Metalloproteinase-3	6	+
167	Bone Morphogenetic Proteins	6	+
168	C-Reactive Protein	6	+
169	Vitamin D	6	+
170	Calcium-Binding Proteins	6	+
171	Polymethyl Methacrylate	6	+
172	Codeine	6	+
173	SOX9 Transcription Factor	6	+
174	Interleukin-8	5	+
175	Cytokines	5	+
176	Biological Products	5	+
177	Hydroxychloroquine	5	+
178	p38 Mitogen-Activated Protein Kinases	5	+
179	Insulin-Like Growth Factor I	5	+
180	Bone Morphogenetic Protein 2	5	+
181	Gels	5	+
182	Interleukin-6	5	+
183	Interleukin-17	5	+
184	Calcium, Dietary	5	+
185	Pyrroles	5	+
186	Betamethasone	4	+
187	Electron Transport Complex IV	4	+
188	Stilbenes	4	+
189	Recombinant Proteins	4	+
190	Prednisolone	4	+
191	Urokinase-Type Plasminogen Activator	4	+
192	Dehydroepiandrosterone	4	+
193	Mitogen-Activated Protein Kinases	4	+
194	Methotrexate	4	+
195	Plasminogen Activator Inhibitor 1	4	+
196	Antibodies, Monoclonal	4	+
197	Plant Oils	4	+
198	Vitamin E	4	+
199	Flavonoids	3	+
200	Aspirin	3	+
201	Fetal Proteins	3	+
202	Parathyroid Hormone	3	+
203	Sodium Chloride	3	+
204	Fish Oils	3	+
205	Nerve Tissue Proteins	3	+
206	DNA	3	+
207	Creatinine	3	+
208	GTPase-Activating Proteins	3	+
209	Neurotrophin 3	3	+
210	Titanium	3	+
211	Methylmethacrylate	3	+
212	Glial Fibrillary Acidic Protein	3	+
213	Naloxone	3	+
214	Formaldehyde	3	+
215	Estradiol	2	+
216	Dynorphins	2	+
217	Receptors, N-Methyl-D-Aspartate	2	+
218	Baclofen	2	+
219	Raloxifene	2	+
220	Hydroxyapatites	2	+
221	GTP-Binding Protein Regulators	2	+
222	Tetracaine	2	+
223	Guanine Nucleotide Exchange Factors	2	+
224	Procollagen	2	+
225	Chondroitin ABC Lyase	2	+
226	Amino Acids	2	+
227	Fragile X Mental Retardation Protein	2	+
228	Methylmethacrylates	2	+
229	Microfilament Proteins	2	+
230	Cholecalciferol	2	+
231	gamma-Aminobutyric Acid	2	+
232	Receptors, Opioid	2	+
233	Neurofilament Proteins	2	+
234	Dynamin I	2	+
235	Chondroitin Sulfate Proteoglycans	2	+
236	Clonidine	2	+
237	Calcium Carbonate	2	+
238	Receptors, AMPA	2	+
239	Calcium Phosphates	2	+
240	Cytoskeletal Proteins	2	+
241	Contractile Proteins	2	+
242	Minerals	2	+
243	Clodronic Acid	2	+
244	Imidazoles	2	+
245	Brain-Derived Neurotrophic Factor	2	+
246	cdc42 GTP-Binding Protein	2	+
247	Estrogens, Conjugated (USP)	2	+
248	Synaptophysin	2	+
249	Proto-Oncogene Proteins c-fos	2	+
250	Green Fluorescent Proteins	2	+
251	Survival of Motor Neuron 2 Protein	2	+
252	Receptors, Opioid, mu	1	+
253	Cyclohexanecarboxylic Acids	1	+
254	Medroxyprogesterone Acetate	1	+
255	rac1 GTP-Binding Protein	1	+
256	Receptors, Neurokinin-1	1	+
257	LDL-Receptor Related Proteins	1	+
258	N-Methylaspartate	1	+
259	Amines	1	+
260	Myelin Proteins	1	+
261	Survival of Motor Neuron 1 Protein	1	+
262	Freund's Adjuvant	1	+
263	Calcium Citrate	1	+
264	HLA-B27 Antigen	1	+
265	Enkephalins	1	+
266	Low Density Lipoprotein Receptor-Related Protein-5	1	+
267	Progesterone Congeners	1	+
268	Nerve Growth Factors	1	+
269	Tantalum	1	+
270	Enkephalin, Methionine	1	+
271	RANK Ligand	1	+
272	Calcitriol	1	+
273	Osteoprotegerin	1	+
274	Stilbamidines	1	+
275	Receptors, Opioid, delta	1	+
276	Enkephalin, Leucine	1	+
277	Guanylate Kinase	1	+
278	SMN Complex Proteins	1	+
279	Ketones	1	+
280	LIM Domain Proteins	1	+
281	Dizocilpine Maleate	1	+
282	Gadolinium DTPA	1	+
283	Fentanyl	1	+
284	Enkephalin, Ala(2)-MePhe(4)-Gly(5)-	1	+
285	Receptors, Adrenergic, alpha-2	1	+
286	Piperidines	1	+
287	Acid Phosphatase	1	+
288	Serotonin	1	+
289	4-Aminopyridine	1	+
290	Idazoxan	1	+
291	Norethindrone	1	+
292	Testosterone	1	+
293	Phosphates	1	+
294	Glutamic Acid	1	+
295	Excitatory Amino Acid Transporter 2	1	+
296	Excitatory Amino Acids	1	+
297	Receptors, Tumor Necrosis Factor	1	+
298	Riluzole	1	+
299	Dexmedetomidine	1	+
300	Calcitonin Gene-Related Peptide	1	+
301	Enkephalin, D-Penicillamine (2,5)-	1	+
302	Strychnine	1	+
303	Ephedrine	1	+
304	Ectodysplasins	1	+
305	Ketamine	1	+
306	Selective Estrogen Receptor Modulators	1	+
307	Opioid Peptides	1	+
308	Naltrexone	1	+
309	Technetium Tc 99m Medronate	1	+
310	Norpregnenes	1	+
311	Yohimbine	1	+
312	Homogentisic Acid	1	+
313	Phosphorus	1	+
314	Chymopapain	1	+
315	Isoflavones	1	+
316	Bicuculline	1	+
317	Estrogen Antagonists	1	+
318	Receptors, Opioid, kappa	1	+
319	Calcium Sulfate	1	+
320	Endorphins	1	+
321	Antigens, CD11b	1	+
322	Intracellular Signaling Peptides and Proteins	1	+
323	Oligopeptides	1	+
324	Minocycline	1	+
325	Receptor Activator of Nuclear Factor-kappa B	1	+
326	Nitric Oxide Synthase Type I	1	+
327	Calcifediol	1	+
328	Amino Acid Transport System X-AG	1	+
329	Pregnatrienes	1	+
330	alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid	1	+
331	Deoxyribonucleases, Type II Site-Specific	1	+
332	Receptors, Calcitriol	1	+
333	Human Growth Hormone	1	+
334	Carrageenan	1	+
335	Endocannabinoids	1	+
336	Ozone	1	+
337	Nandrolone	1	+
338	Receptors, Serotonin, 5-HT3	1	+
339	Fish Venoms	1	+
340	GAP-43 Protein	1	+
341	Excitatory Amino Acid Transporter 1	1	+
342	6-Cyano-7-nitroquinoxaline-2,3-dione	1	+
343	Procaine	1	+
344	Toremifene	1	+
345	Myelin Basic Protein	1	+
346	Fibroblast Growth Factor 1	1	+
347	Benzylidene Compounds	1	+
348	Receptors, Glycine	1	+
349	Neurofibromin 1	1	+
350	Vitamin K 1	1	+
351	Sufentanil	1	+

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