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1/5. Primary cutaneous zygomycosis due to absidia corymbifera in a patient with AIDS.

    A case of primary cutaneous zygomycosis due to absidia corymbifera in a patient with AIDS is described. The lesions, which were located on the forehead, jaw and chest, were intradermal, extending into the subcutaneous fat and did not appear to be associated with any trauma. No deep-seated infection was evident suggesting that the superficial lesions were exogenous in origin. The possible aetiology of this infection is discussed.
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ranking = 1
keywords = zygomycosis
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2/5. zygomycosis (mucormycosis) and hiv infection: report of three cases and review.

    We report three cases of zygomycosis (mucormycosis) occurring in three individuals infected with the human immunodeficiency virus (hiv) and review 12 other published cases. We present the only two case reports of disseminated zygomycosis in AIDS patients, and the only AIDS patient with renal zygomycosis to survive without nephrectomy, receiving intravenous (i.v.) amphotericin alone. coinfection with zygomycosis and hiv is rare, occurs primarily in patients with low CD4 lymphocyte counts, does not always require the usual predisposing conditions for zygomycosis, and may be the presenting opportunistic infection among hiv-infected persons. Transient episodes of neutropenia occurring within 4 months before presentation may be a risk factor for this disease. zygomycosis may arise in multiple sites including the basal ganglia, cutaneous tissue, kidney, respiratory tract, and may be disseminated. Occurring more commonly in, but not restricted to, injection drug users, it is significantly associated with sites other than basal ganglia in those patients with advanced hiv disease or AIDS. The presenting symptoms are related to the site of involvement, and the illness may develop insidiously or progress rapidly to a fulminant course. Successful therapy usually consists of surgical debridement and intravenous amphotericin b. overall mortality in this review is 40%, and is significantly associated with sites of disease inaccessible to surgical debridement.
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ranking = 1
keywords = zygomycosis
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3/5. Renal infection due to absidia corymbifera in an AIDS patient.

    A case of renal zygomycosis due to absidia corymbifera in an heroin addict suffering from AIDS (phase IV C2) is described. diagnosis was by histopathology after nephrectomy, but A. corymbifera was isolated several times from urine and from the exudate from a fistula in the surgical wound. After amphotericin b treatment (1.5 g overall dose) clinical cure and negative cultures were obtained. No relapses were observed until death 1 year later from pneumocystis carinii pneumonia.
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ranking = 0.2
keywords = zygomycosis
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4/5. zygomycosis and hiv infection.

    The severe immunosuppression associated with hiv infection increases susceptibility to opportunistic fungi. We describe a primary gangrenous cutaneous infection caused by rhizopus arrhizus in an hiv-infected intravenous narcotic user. In addition, we review nine reported cases of zygomycosis in hiv-infected patients and discuss the frequency and outcome of zygomycosis in hiv infection. Eight of 10 patients were intravenous drug users. Cutaneous infection occurred in four patients. Another case was associated with drug-induced neutropenia. With treatment, 60% of the patients recovered. hiv-induced immunosuppression rarely predisposes to zygomycosis except in intravenous drug users or persons with other risk factors for this fungal infection.
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ranking = 0.6
keywords = zygomycosis
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5/5. Successful medical management of isolated renal zygomycosis: case report and review.

    We describe the medical management of isolated renal zygomycosis in an adult patient with AIDS during chemotherapy for AIDS-related lymphoma. After initial presentation during the first cycle of chemotherapy, the infection was contained within the kidney following recovery of the neutrophil count without medical or surgical intervention. Since he was not considered to be a candidate for nephrectomy, his infection was treated with amphotericin b lipid complex during subsequent chemotherapy. neutropenia was minimized by the addition of cytokine support therapy with granulocyte colony-stimulating factor and reduced doses of chemotherapy. Following this strategy, his lymphoma completely resolved, and renal zygomycosis was controlled. At the time of this writing, he had been in complete remission for 18 months without evidence of progressive fungal infection. This report and our literature review indicate that isolated renal zygomycosis can be associated with a favorable prognosis, occurs with greatest frequency in patients with AIDS, is associated with parenteral access, and may be managed by medical therapy alone.
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ranking = 1.4
keywords = zygomycosis
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