Cases reported "adenoma, pleomorphic"

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11/479. Cytomorphological features of salivary duct carcinoma ex pleomorphic adenoma: diagnosis by fine-needle aspiration biopsy with histologic correlation.

    We report a case of salivary duct carcinoma arising from a pleomorphic adenoma (ex pleomorphic adenoma) in a parotid salivary gland of a 70-yr-old man. Fine-needle aspiration biopsy showed two distinct subsets of cells. There was the typical biphasic pattern of pleomorphic adenoma consisting of bland epithelial cells admixed with uniform spindle-shaped cells and chondromyxoid stroma. In addition, there were features of salivary duct carcinoma best demonstrated by necrosis and the presence of large polygonal cells arranged either singly or in rosettes, clusters or sheets reminiscent of ductal carcinoma of the breast. This case illustrates that the presence of background large polygonal cells and necrosis in an otherwise typical pleomorphic adenoma may suggest the diagnosis of a high-grade carcinoma, namely salivary duct carcinoma, which portends poor prognosis and requires aggressive treatment. Differential diagnosis from other carcinomas known to arise in pleomorphic adenoma is discussed. ( info)

12/479. Unusual presentations of pleomorphic adenoma and adenoid cystic carcinoma of the lacrimal gland.

    PURPOSE: To report two atypical cases of pleomorphic adenoma and adenoid cystic tumours of the lacrimal gland. methods: Two case reports are presented. The first is of a 65-year-old female with a long history of right hypoglobus with sudden recent worsening. Computed tomography (CT) showed a round, well-defined lesion in the fossa for the lacrimal gland with an anterior hypodense extension suggestive of possible malignancy in a pleomorphic adenoma. The tumour in the second case, a 35-year-old male, was diagnosed after presentation following a relatively minor periorbital injury. The smooth rounded mass on CT scan was suggestive of a benign lacrimal gland tumour. RESULTS: The lesion in case 1 was excised with a diagnosis of haemorrhage within a pleomorphic adenoma. The lesion in case 2 was excised with a diagnosis of adenoid cystic carcinoma of the lacrimal gland with pseudocapsule. CONCLUSIONS: Haemorrhagic cyst developing beneath the pseudocapsule of a pleomorphic adenoma should be considered in the differential diagnosis of secondary development of malignancy in a pleomorphic adenoma. Adenoid cystic tumours of the lacrimal gland can present with a pseudocapsule. ( info)

13/479. Synchronous unilateral parotid neoplasms of different histological types.

    The occurrence of multiple tumours in the salivary glands is an unusual phenomenon and the simultaneous development of tumours different types is extremely rare. Two cases are presented with synchronous tumours of the parotid gland of different histological types. The first was a Warthin tumour in combination with a metastatic lung carcinoma and the second was a pleomorphic adenoma in combination with non-Hodgkin's malignant lymphoma. ( info)

14/479. Synchronous pleomorphic adenomas of the major salivary glands: a case report.

    The presentation of multiple distinct tumors in major salivary glands is rare. Although the most common tumor with bilateral synchronous or metachronous development is the Warthin tumor, pleomorphic adenomas have been diagnosed simultaneously as well. We report the case of a female patient who was diagnosed with pleomorphic adenomas in the right parotid and submandibular glands, concomitant with sialolithiasis affecting the submandibular gland. This patient had been exposed to head and neck radiotherapy in childhood, which may have played a role in the development of her tumors. A review of the relevant literature is included. ( info)

15/479. Benign pleomorphic adenoma arising from the palpebral lobe of the lacrimal gland associated with elevated intraocular pressure.

    A 46-year-old man complained of a painless mass in the left upper eyelid. At age 51 years, the patient complained of dull pain in the left eye and diplopia. His left intraocular pressure had increased to 33 mm Hg. No proptosis was noted. The nontender mass in the eyelid was palpable. Computed tomography showed a mass anterior to the orbital rim compressing the globe. The lesion was removed en bloc by a transconjunctival approach. Histopathologic examination of the excised mass showed myxomatous stroma and highly cellular epithelial areas. Postoperatively, the left intraocular pressure normalized. To our knowledge, benign pleomorphic adenomas arising from the palpebral lobe of the lacrimal gland associated with elevated intraocular pressure, as demonstrated in our patient, may be rare. ( info)

16/479. CT of intranasal pleomorphic adenoma.

    Intranasal pleomorphic adenoma is rare. We report the CT features this tumor in a 41-year-old woman who presented to us with right nasal obstruction and a 2-day history of epistaxis. ( info)

17/479. A new observation of the Carney's triad with long follow-Up period and additional tumors.

    The etiology of the Carney's triad (gastrointestinal stromal tumors, pulmonary chondromas, and paragangliomas) is unknown, and only 57 cases have been reported since its identification in 1977. We report the clinical course of a female with the complete triad and some additional tumors. Bilateral vagal paragangliomas were treated surgically and with radiotherapy between the ages of 24 and 26 years. Subsequently she underwent surgery for a gastric leiomyosarcoma (27 years), a pleomorphic adenoma of the parotid gland (49 years) and a multifocal breast cancer with axillary spread (50 years). A calcified lesion was also noticed in the left lung, the radiologic diagnosis of which was consistent with chondroma. A mediastinal paraganglioma, detected at 56 years on a control X-ray of the chest, was partially excised at 63 years. At the last control, performed at 66 years, the patient was alive with residual cervical and mediastinal paraganglioma. Her younger brother was affected by Hirschsprung's disease and died at 54 years of rectal cancer. Her daughter is 33 and has been suffering since birth with severe constipation. In conclusion, this is one of the longest followed-up patients with Carney's triad. Her case illustrates the need for early recognition of the setting in order to detect the component tumors at a stage when surgery may be curative, and careful and life-long follow-up, both because the multicentricity of the classic components tends to manifest metachronously and because of the tendency to develop other tumors, some of which may be malignant. Furthermore, the presence of Hirschsprung's disease in the patient's family, coupled with the alleged common origin of two component lesions from derivatives of the neural crest, open new avenues for the understanding of this disorder. ( info)

18/479. Botulinum toxoid in the management of gustatory sweating (Frey's syndrome) after superficial parotidectomy.

    Botulinum toxin has been successfully used to treat Frey's syndrome occurring in a 31-year-old patient following superficial parotidectomy for pleomorphic adenoma. An initial injection of 7.5 U (0.3 ml over 6 cm2 of cheek) resulted in 3 months' resolution of gustatory sweating and flushing and a second injection 12 months' symptomatic improvement. The symptoms recurred after further facial surgery. ( info)

19/479. Pleomorphic adenoma of the nasal septum.

    Pleomorphic adenoma is the commonest benign tumour of the major salivary glands. It can also occur in minor salivary glands, mainly in the oral cavity, but also in other sites in the head and neck both within and outwith the upper aerodigestive tract. We present a rare case of pleomorphic adenoma of the nasal septum with consideration of the clinical management and a review of the literature. ( info)

20/479. An unusually large, solid tumor of the parotid gland.

    Of the parotid gland tumors, benign pleomorphic adenomas are the most commonly encountered. Although occurring relatively frequently in the general population, it is rare for the surgical community to encounter one that weighs more than a few ounces. The authors report a woman who avoided early surgical intervention and eventually presented with an extraordinarily large parotid gland tumor. This is the largest solid (without cystic change), benign pleomorphic adenoma of the parotid gland in the English medical literature, weighing 8.03 kg. ( info)
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