Cases reported "Agammaglobulinemia"

Filter by keywords:



Filtering documents. Please wait...

1/6. Hepatitis B surface antigen variant with multiple mutations in the a determinant in an agammaglobulinemic patient.

    A patient with agammaglobulinemia developed acute hepatitis that progressed to chronic liver disease with high levels of hepatitis b virus (HBV) dna in the absence of detectable HBsAg. Sequencing of the a determinant region of HBsAg revealed multiple amino acid substitutions that, unusually, also included a substitution at position 122 that defines subtype specificity. All of these mutations had a profound effect on the antigenicity of this region, which led to the complete failure of variant detection by commercially available routine diagnostic assays or laboratory-based monoclonal antibody assays.
- - - - - - - - - -
ranking = 1
keywords = specificity
(Clic here for more details about this article)

2/6. HLA-D restriction of "naturally occurring" MLR suppressor cells in acquired common variable hypogammaglobulinemia.

    Cells with capacity to suppress the mixed lymphocyte response (MLR) were detected in two patients with acquired common variable hypogammaglobulinemia (ACVH). No specificity with respect to the stimulating HLA type was observed. In one case of ACVH available for extensive study, there was evidence for HLA-D restriction of the suppressor cells. The patient's lymphocytes specifically suppressed the MLR of subjects who carried the same HLA-D type. family studies confirmed that the suppressor activity was restricted to HLA-D, not DR, and segregated with the appropriate HLA haplotype. These observations suggest that an immune suppressor gene mapping in the HLA region may be involved in the pathogenesis of common variable hypogammaglobulinemia.
- - - - - - - - - -
ranking = 1
keywords = specificity
(Clic here for more details about this article)

3/6. Ulcerative colitis in a patient with anti-B lymphocytotoxin and hypogammaglobulinemia.

    Lymphocytotoxins (LCT) have been recently reported in the serum of patients with inflammatory disease of the bowel, but up to now these antibodies have shown no specificity for B or T lymphocyte subpopulations. A 32-year-old patient with chronic ulcerative colitis, primary hypogammaglobulinemia and a very low number (0.5 to 1.5%) of B lymphocytes in peripheral blood is described. The presence in the serum of a LCT reacting specifically with B cells was demonstrated by cytotoxicity and direct immunofluorescence experiments. Intestinal immunofluorescence studies indicated a dichotomy between blood and gut immunoglobulins, and showed a heterogeneous distribution of plasma cells of the three major classes from the jejunum to the rectum. The significance of the association of hypogammaglobulinemia, chronic ulcerative colitis, and anti-B LCT is discussed. To explain the dissociation between blood and gut immunoglobulins, it is suggested that the intestine was, in this patient, a privileged site for differentiation of B cells.
- - - - - - - - - -
ranking = 1
keywords = specificity
(Clic here for more details about this article)

4/6. Suppressor t-lymphocytes and auto-anti-B-cell cytotoxic t-lymphocytes in a case of acquired hypogammaglobulinaemia.

    A case of acquired hypogammaglobulinaemia has been examined. Total and differential leucocyte counts and distribution were normal as were the lymphocyte sub-populations when defined by surface membrane immunoglobulin, E-, EA- and EAC-rosette techniques. The proliferative response of unseparated lymphocytes to PHA and Con-A was normal while the response to PWM was clearly impaired. In contrast, testing of purified b-lymphocytes by PWM was within the normal range. The response to PWM was found to be depressed by adding the patient's t-lymphocytes to autologous b-lymphocytes as well as to b-lymphocytes from 10 normal, healthy controls. The patient's t-lymphocytes were further tested for cytotoxicity against autologous. b-lymphocytes and b-lymphocytes from the 10 control individuals. Cytotoxicity was observed against autologous b-lymphocytes and against the b-lymphocytes of 3 controls. These findings indicate the presence of peripherally circulating unspecific T-suppressor lymphocytes and cytotoxic t-lymphocytes of some immunogenetic specificity. The suppressor and cytotoxic t-lymphocytes may separately or in combination be involved in the pathogenesis of hypogammaglobulinaemia. Thus, these findings are equivocal but underline the immunologic aspects of the pathogenesis.
- - - - - - - - - -
ranking = 1
keywords = specificity
(Clic here for more details about this article)

5/6. Partial immunologic reconstitution of a patient with acquired agammaglobulinemia: a transient phenomenon accompanying therapeutic plasmapheresis.

    A patient with acquired agammaglobulinemia was treated with plasmapheresis. The rationale for this procedure was based on the presence of a cytotoxic autoantibody with specificity for helper (TH2-) T lymphocytes. plasmapheresis reduced the autoantibody concentration to undetectable levels, which resulted in an increase number of helper T cells. These T cells provided normal in vitro helper activity. plasmapheresis did not correct a concomitant suppressor T-cell defect, and the clinical remission ended during the fifth month of exchange therapy.
- - - - - - - - - -
ranking = 1
keywords = specificity
(Clic here for more details about this article)

6/6. Use of amplification and sequencing of the 16S rRNA gene to diagnose mycoplasma pneumoniae osteomyelitis in a patient with hypogammaglobulinemia.

    A splenectomized patient with hypogammaglobulinemia who was hospitalized because of a high-grade fever subsequently developed osteomyelitis. Although pus cultures were repeatedly sterile, polymerase chain reaction (PCR) analysis with use of 16S rRNA gene primers with a broad specificity detected bacterial dna in pus samples. Subsequent nucleotide base determination of the amplified dna demonstrated that the detected dna was derived from mycoplasma pneumoniae. The results were confirmed by a PCR assay with use of M. pneumoniae-specific primers. Our findings confirm the usefulness of 16S rRNA gene amplification and analysis in the rapid and specific diagnosis of infectious osteomyelitis and reaffirm the role of such methods in detecting fastidious or uncultivable pathogens.
- - - - - - - - - -
ranking = 1
keywords = specificity
(Clic here for more details about this article)


Leave a message about 'Agammaglobulinemia'


We do not evaluate or guarantee the accuracy of any content in this site. Click here for the full disclaimer.