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1/2. hypersensitivity systemic reaction following intravesical bacillus Calmette-Guerin: successful treatment with steroids.

    Intravesical bacillus Calmette-Guerin (BCG) is an effective treatment for superficial bladder carcinoma. Serious complications, including disseminated BCG infection, are infrequent. We report a case of granulomatous hepatitis with pneumonitis following intravesical administration of BCG. Cultures for mycobacteria were negative in sputum, bronchoalveolar lavage, liver and blood specimens. All symptoms disappeared within days after steroid therapy. hypersensitivity reaction should be considered in patients with systemic symptoms after immunotherapy with BCG.
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2/2. T helper cell alveolitis after bacillus Calmette-Guerin immunotherapy for superficial bladder tumor.

    We report a case of T helper cell alveolitis after intravesical bacillus Calmette-Guerin (BCG) immunotherapy for a superficial bladder tumor. Despite the clinical appearance of miliary pulmonary tuberculosis no mycobacterial agent was found. Therefore, we concluded that the patient had a hypersensitivity reaction similar to sarcoidosis. The condition improved after immunosuppressive therapy with glucocorticosteroids. Differentiation of bronchoalveolar cells could be useful in distinguishing hypersensitivity to infection with BCG.
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keywords = bacillus
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