Cases reported "Anal Gland Neoplasms"

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1/10. Perianal mucinous adenocarcinoma.

    Perianal mucinous adenocarcinoma, also known as anal duct or anal gland carcinoma, is a rare tumor usually associated with chronic fistulae-in-ano. Whether the tumor occurs primarily and the fistula is a secondary manifestation, or whether this tumor arises in a chronic fistulous tract is debatable. Diagnosis can be made only by open deep biopsy of the buttock mass, and, due to the low grade histologic appearance of the malignancy, an incorrect diagnosis is frequently made. Treatment is abdominoperineal resection with wide removal of the buttock mass. ( info)

2/10. Squamous carcinoma arising in a giant peri-anal condyloma associated with human papillomavirus types 6 and 11.

    A case is reported of squamous carcinoma of the peri-anal region arising in a giant condyloma. In situ dna hybridization showed human papillomavirus (HPV) types 6 and 11. These HPV types are commonly demonstrated in ano-genital condylomas but have not previously been reported in association with malignant change at this site. ( info)

3/10. Reversible leukoencephalopathy caused by 5-fluorouracil derivatives, presenting as akinetic mutism.

    Two cancer patients are reported, who presented with altered consciousness 2 and 3 months, respectively, after the administration of 5-fluorouracil derivatives, and progressed to a state of akinetic mutism. At first a presumptive diagnosis of metastatic brain tumor was made. However, the result of a cerebrospinal fluid cytology for malignancy was negative, and computed tomography (CT) scanning revealed diffuse decreased attenuation of the cerebral white matter, indicative of leukoencephalopathy, without association of mass lesion. Upon discontinuing the drugs, both patients made significant recovery and the decreased attenuation on the CT also disappeared. The significance of the early diagnosis of this pathology is emphasized. ( info)

4/10. bowen's disease: a rare condition in an unusual extension.

    The detection of bowen's disease, a very rare condition in an unusual extension--literally covering the anogenital area--and the successful more conservative way of handling the lesions, through surgical separate steps, prompted the authors to review the literature and to report the case. ( info)

5/10. Primary adenocarcinoma of an anal gland with secondary perianal fistulas.

    A case of primary mucinous (colloid) adenocarcinoma associated with multiple perianal fistulas and a supra-anal intergluteal abscess of a short duration is described. The origin of this tumor has been much debated. Some believe that the tumor occurs primarily in an anal duct or its glands with secondary fistula formation, whereas others claim that the tumor arises in a chronic fistulous tract. The present study substantiates the former concept on the basis of the mode of clinical presentation and the pathologic findings of a large tumor, without involvement of the anorectal mucosa. The residual anal ducts and glands were found in close relationship with the tumor. ( info)

6/10. Bowenoid papulosis in the perianal region.

    A case is described of a patient who had numerous violaceous papular lesions around the anus which appeared benign clinically, but which on histological examination showed changes of carcinoma-in-situ. The case was followed up for three years after local excision but did not recur. Such cases need careful evaluation before radical operation in view of the recently recognised entity of "Bowenoid papulosis". ( info)

7/10. Anal gland adenocarcinoma presenting as painless scrotal swelling in a 73-year-old man: a case report.

    A 73-year-old man presented with progressive painless scrotal swelling without systemic, urinary, or anorectal complaints. The scrotal lymphedema was due to massive bilateral metastatic replacement of the superficial inguinal lymph nodes. The primary tumor was an inoperable, rapidly fatal adenocarcinoma arising from the anal glands of the upper canal. Thus, in the evaluation of scrotal swelling of obscure etiology in older patients, occult carcinomas of the anal glands must be considered and appropriate steps taken to establish the diagnosis. ( info)

8/10. Perianal Paget's disease years after rectal adenocarcinoma removal.

    BACKGROUND: Perianal Paget's disease often coincides with anorectal carcinoma, which extends into the epidermis from a contiguous organ. OBJECTIVE: Our purpose was to present a patient with perianal Paget's disease who had a rectal adenocarcinoma excised 14 years previously in another hospital and to determine whether there is a relationship between the perianal Paget's disease and the rectal adenocarcinoma. methods: We examined the resected specimens of the rectal adenocarcinoma and the perianal Paget's disease histologically. RESULTS: In the resected specimen of the rectal adenocarcinoma, Paget cells were present within the anal epidermis adjacent to the rectal adenocarcinoma. The Paget cells showed the same histochemical and immunohistological findings as the adenocarcinoma cells. CONCLUSION: There was a close relationship between the perianal Paget's disease and the rectal adenocarcinoma. It is probable that the Paget cells were derived from direct spread from the rectal adenocarcinoma. ( info)

9/10. hidradenitis suppurativa, Dowling Degos disease and perianal squamous cell carcinoma.

    A patient with hidradenitis suppurativa (HS) is described in association with Dowling Degos disease and perianal squamous cell carcinomas. As the initial treatment for HS failed to give any satisfactory relief he sought no further medical help for the subsequent 40 years. This patient illustrates the management difficulties in HS and the need for regular surveillance to exclude the development of anogenital squamous cell carcinoma. Previous reports of hidradenitis suppurativa in association with Dowling Degos disease are reviewed and the aetiology is discussed. ( info)

10/10. Three cases of verrucous carcinoma.

    Verrucous carcinoma of the skin and mucosa is an uncommon clinicopathological variant of low grade squamous cell carcinoma. Here, we present three different clinical types of verrucous carcinoma. The first patient presented with an anogenital verrucous carcinoma, also known as Buschke-Loewenstein tumour. The second patient had verrucous carcinoma of the heel with endophytic growth (i.e. epithelioma cuniculatum) and the third patient had gluteal verrucous carcinoma with a cauliflower-like appearance. Clinically, the lesion of the first patient best resembled giant condyloma accuminatum without any prominent verrucous component, whereas the second patient showed a big deep ulcer on the heel. None of the patients had metastasis. The diagnosis was confirmed with biopsy and total excision was performed in all cases. Although the cases have different clinical presentations in different locations, we think that they should be considered as a single entity; that is, verrucous carcinoma. ( info)
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