1/9. subcutaneous fat necrosis of the newborn following hypothermia and complicated by pain and hypercalcaemia.A female infant was delivered at term with complications of severe meconium aspiration and birth asphyxia. Surface cooling was performed in the first 24 hours as part of the management of her birth asphyxia. Woody erythema was noted at 24 hours, followed by the formation of red-purple nodules on the 6th day. Clinical findings in the first 24 hours were suggestive of cold panniculitis. However, clinical and histological findings progressed to be in keeping with the diagnosis of subcutaneous fat necrosis of the newborn (SCFN). Furthermore, the immediate postnatal period was complicated by pain resistant to treatment with opiates. Asymptomatic hypercalcaemia was noted on periodic testing at 7 weeks and treated by rehydration, diuretics, prednisolone, etidronate and a low-calcium and -vitamin d diet. A review of the clinical and histological findings of the relevant panniculitides occurring in the postnatal period is presented, as well as a review of the treatment of hypercalcaemia in SCFN.- - - - - - - - - - ranking = 1keywords = subcutaneous fat, fat (Clic here for more details about this article) |
2/9. subcutaneous fat necrosis associated with severe hypocalcaemia in a neonate.subcutaneous fat necrosis (SFN) of the newborn is an uncommon disorder of the adipose tissue, mostly affecting full-term or post-term newborns who experience perinatal distress. The lesions of SFN typically occur during the first six weeks of life; they are usually self-limited and no specific therapy is required. The disorder may be rarely complicated with hypercalcaemia. We present the case of a neonate with perinatal asphyxia who manifested SFN followed by hypocalcaemia instead of hypercalcaemia and a biochemical profile of pseudohypoparathyroidism four weeks after the eruption of skin lesions. The infant was treated with alfacalcidiol. blood biochemistry was normalized within one week and serum parathyroid hormone levels declined to normal over the next two months. It is suggested that perinatal asphyxia was the common etiopathogenetic factor for the development of both SFN and pseudohypoparathyroidism.- - - - - - - - - - ranking = 0.0017251397434481keywords = fat (Clic here for more details about this article) |
3/9. subcutaneous fat necrosis of the newborn: be aware of hypercalcaemia.subcutaneous fat necrosis of the newborn is an uncommon, self-limiting panniculitis that usually occurs in full-term infants as a consequence of perinatal asphyxia. The cutaneous involvement may be associated with metabolic complications such as hypoglycaemia, thrombocytopenia, hypertriglyceridemia, anemia and hypercalcaemia. The delayed onset of hypercalcaemia, 1-6 months after the development of the skin manifestations, imposes a prolonged follow-up to avoid its acute toxic effects on cardiovascular and renal systems and the more durable metastatic calcifications.- - - - - - - - - - ranking = 0.0017251397434481keywords = fat (Clic here for more details about this article) |
4/9. subcutaneous fat necrosis with thrombocytopenia in a newborn infant.A case of subcutaneous fat necrosis (SCFN) in a newborn who had suffered from asphyxia secondary to meconium aspiration is described. During the third week of life, bluish-red subcutaneous nodules were noticed. A biopsy of the lesions showed subcutaneous necrosis with fat cells containing needle-like crystals with reactive inflammatory infiltrates. Peripheral transient thrombocytopenia was observed prior to the appearance of subcutaneous fat necrosis. The good prognosis is stressed.- - - - - - - - - - ranking = 1.9989649161539keywords = subcutaneous fat, fat (Clic here for more details about this article) |
5/9. X-linked neonatal myotubular myopathy.We have described a family with X-linked myotubular myopathy that was clinically manifest in the neonatal period and compared it with the clinical picture and course of the disease in similar reported cases. Clinical expression of the disease in the newborn period is not always lethal. Despite a fatal outcome in the family reported here, a review of the literature indicates that aggressive treatment of short-term respiratory insufficiency at birth is justified.- - - - - - - - - - ranking = 0.00034502794868961keywords = fat (Clic here for more details about this article) |
6/9. nephrocalcinosis and nephrolithiasis due to subcutaneous fat necrosis with hypercalcemia in two full-term asphyxiated neonates: sonographic findings.subcutaneous fat necrosis leading to hypercalcemia is rare but well documented in asphyxiated neonates. This paper presents two such neonates in whom sonography revealed the development of nephrocalcinosis and nephrolithiasis. The kidneys had initially been shown to be normal sonographically. In one infant, nephrocalcinosis developed as increasing echogenicity of the medullary pyramids. In the other, increased echogenicity of the renal cortex of uncertain cause developed together with nephrolithiasis. These sonographic appearances have not been described previously in this entity.- - - - - - - - - - ranking = 3.9948245807697keywords = subcutaneous fat, fat (Clic here for more details about this article) |
7/9. subcutaneous fat necrosis in a neonate, in association with aberrant plasma lipid and lipoprotein values.A newborn infant with subcutaneous fat necrosis after perinatal hypoxia was found to have several abnormalities of plasma lipids. Further studies are needed to determine whether such abnormalities contribute to the pathophysiology of the skin lesions.- - - - - - - - - - ranking = 1keywords = subcutaneous fat, fat (Clic here for more details about this article) |
8/9. Successful renal transplantation in Jeune syndrome type 2.Jeune syndrome (asphyxiating thoracic dystrophy) is a rare inherited disease which is fatal in early childhood in 70% of cases. Severe renal involvement may occur and lead to chronic renal insufficiency in patients who survive respiratory failure. Therefore the opportunity to perform kidney transplantation is quite rare. We report a successful cadaver renal transplantation in a 10-year-old boy with Jeune syndrome type 2.- - - - - - - - - - ranking = 0.00034502794868961keywords = fat (Clic here for more details about this article) |
9/9. Is breast feeding in bed always a safe practice?OBJECTIVES: To examine whether infants who are being breast fed in their mother's bed are at increased risk of accidental suffocation. MATERIALS AND methods: review of all cases of unexpected infant death occurring in south australia, Australia during 1996 was undertaken to ascertain whether any cases of sudden infant death had occurred in association with breast feeding in the parental bed. All infants had death scene examinations, history reviews and full autopsies performed. RESULTS: Three of a total of 28 cases of unexpected infant death were identified where accidental asphyxia associated with breast feeding-related cosleeping was considered a likely cause of death. Maternal fatigue was a factor in each of the three cases. There were nine SIDS cases and 16 other cases which included non-accidental injury, accidental asphyxia, congenital cardiovascular disease and sepsis. CONCLUSIONS: Accidental asphyxia is a rare but possible outcome if mothers fall asleep in bed with their infants while breast feeding. nursing mothers should be made aware of the potential dangers of fatigue and sedation in such circumstances. breast feeding out of bed, or in the company of a second person who can ensure the safety of the infant if breast feeding is occurring in bed may prevent these unfortunate fatalities.- - - - - - - - - - ranking = 0.0010350838460688keywords = fat (Clic here for more details about this article) |