11/13. The risk of acquiring lyme disease or babesiosis from a blood transfusion.To determine the risk of acquiring lyme disease or babesiosis from blood transfusion, serum was collected before and 6 weeks after patients received multiple transfusions during cardiothoracic surgery and antibodies to borrelia burgdorferi and babesia microti were measured. Of 155 subjects, 149 received 601 total units of packed red blood cells (PRBC) and 48 received 371 total units of platelets. No patient developed clinical or serologic evidence of lyme disease; 1 (who received 5 units of PRBC) developed clinical and serologic evidence of babesiosis. The risk of acquiring lyme disease from a transfused unit of PRBC was 0 (95% confidence interval [CI], 0-0.5%) and from a transfused unit of platelets was 0 (95% CI, 0-0.8%); the same risks for babesiosis were 0.17% (95% CI, 0.004%-0.9%) and 0 (95% CI, 0-0.8%), respectively. The risk of acquiring either lyme disease or babesiosis from a blood transfusion in connecticut is very low.- - - - - - - - - - ranking = 1keywords = burgdorferi (Clic here for more details about this article) |
12/13. A fatal case of babesiosis in missouri: identification of another piroplasm that infects humans.OBJECTIVE: To characterize the etiologic agents (MO1) of the first reported case of babesiosis acquired in missouri. DESIGN: Case report, serologic testing, animal inoculations, and molecular studies. SETTING: Southeastern missouri. PATIENT: A 73-year-old man who had had a splenectomy and had a fatal case of babesiosis. MEASUREMENTS: serum specimens from the patient were assayed by indirect immunofluorescent antibody testing and immunoprecipitation for reactivity with antigens from various Babesia species. Whole blood obtained from the patient before treatment was inoculated into hamsters and jirds and into calves and bighorn sheep that had had splenectomy and were immunosuppressed with dexamethasone. Piroplasm-specific nuclear small-subunit ribosomal dna was recovered from the patient's blood by using broad-range amplification with the polymerase chain reaction; a 144 base-pair region of the amplification product was sequenced; and phylogenetic analysis was done to compare MO1 with various Babesia species. RESULTS: Indirect immunofluorescent antibody testing showed that the patient's serum had strong reactivity with Babesia divergens, which causes babesiosis in cattle and humans in europe, but that it had minimal reactivity with B. microti and WA1, which are the piroplasms previously known to cause zoonotic babesiosis in the united states. Immunoprecipitations showed that MO1 is more closely related to B. divergens than to B. canis (a canine parasite). None of the experimentally inoculated animals became demonstrably parasitemic. Phylogenetic analyses, after dna sequencing, showed that MO1 is most closely related to B. divergens (100% similarity). CONCLUSIONS: Although MO1 is probably distinct from B. divergens, the two share morphologic, antigenic, and genetic characteristics; MO1 probably represents a Babesia species not previously recognized to have infected humans. Medical personnel should be aware that patients in the united states can have life-threatening babesiosis even though they are seronegative to B. microti and WA1 antigen.- - - - - - - - - - ranking = 0.030576261805346keywords = lyme (Clic here for more details about this article) |
13/13. coinfection with babesia microti and borrelia burgdorferi in a western wisconsin resident.A 68-year-old woman, who had not traveled outside of western wisconsin, was hospitalized after 4 weeks of chills, fevers, myalgias, neuralgias in her right arm, and pain in the right upper quadrant of her abdomen. physical examination revealed hepatosplenomegaly, and laboratory studies showed anemia, thrombocytopenia, increased aspartate transaminase level, and microscopic hematuria. Wright's stain of a blood smear revealed intraerythrocytic organisms consistent with Babesia species. A polymerase chain reaction of whole blood specimens along with an increased serologic titer confirmed the diagnosis of babesia microti. Indirect immunofluorescent antibody serology and Western blot analysis revealed a simultaneous infection with borrelia burgdorferi. coinfection with B. microti and B. burgdorferi may occur in endemic areas where both organisms are carried by the same tick vector, ixodes scapularis. The intensity and duration of illness seem to be greatest in patients with concurrent infection.- - - - - - - - - - ranking = 6.0305762618053keywords = burgdorferi, lyme (Clic here for more details about this article) |
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