Cases reported "Bone Diseases"

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21/30. Sternocostoclavicular hyperostosis. A case report and review of the literature.

    Sternocostoclavicular hyperostosis (SCCH) or intersternocostoclavicular ossification is a recently recognized disorder of unknown origin. SCCH is characterized by painful, condensing hypertrophy of the sternum, both clavicles, and the upper ribs. Since its original description by Sonozaki in 1974, approximately 40 cases have been reported, mainly in the Japanese literature. This peculiar hyperostotic syndrome is often misdiagnosed. The differentiation from osteitis deformans can be difficult. Clinically, the disease produces a swelling in the upper chest area with persistent, pulling pain exacerbated by cold and dampness. The condition is a nonspecific inflammatory syndrome. Radiographs usually show symmetric hyperostosis of the sternal portions of the clavicles, synostosis of the sternoclavicular joints, a thickened sternum, and varying degrees of involvement of the upper ribs and intercostoclavicular space. biopsy specimens reveal hyperostotic sclerosis of the cancellous bone. Although the cause of the syndrome is unknown, clinical, radiologic, and histologic findings indicate that it represents a distinct entity. The treatment of SCCH remains symptomatic.
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ranking = 1
keywords = sternocostoclavicular, hyperostosis
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22/30. Caffey's disease: a case originating in the first metatarsal and review of a 12 year experience.

    This paper describes an infant with Caffey's disease who presented with swelling of the first metatarsal shown as hyperostosis histologically. He then developed scapular sclerosis and new bone formation. The mandible became involved 26 days after onset. A review of a 12 year experience with Caffey's disease (33 patients) disclosed a definite decrease in the number and percentage of patients seen since 1968.
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ranking = 0.0086629529384443
keywords = hyperostosis
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23/30. Bilateral nasal bone osteophytosis associated with short-term oral isotretinoin therapy for cystic acne vulgaris.

    Bilateral 2.5 and 3.0 mm nasal bone osteophytes developed five weeks following the initiation of oral isotretinoin therapy (50 mg daily) for severe cystic acne vulgaris in a healthy 30-year-old white woman who had undergone uneventful rhinoplasty 12 years earlier. Histologically mature bone fragments were removed at surgery. vitamin a and its analogs have been reported to cause hyperostosis of the vertebrae and long bones, but no known reports link them to nasal bone changes. Clinically significant nasal bone osteophytosis may be another adverse reaction to oral isotretinoin therapy.
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ranking = 0.0086629529384443
keywords = hyperostosis
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24/30. Tumoral calcinosis, diaphysitis, and hyperphosphatemia.

    Three children with hyperphosphatemic tumoral calcinosis, including 2 siblings, presented with recurrent pain and swelling of the legs. Laboratory tests, radiographs, and biopsy showed reactive new bone formation of unknown etiology in the diaphyses. The authors hypothesize a relationship between tumoral calcinosis, hyperostosis, and hyperphosphatemia and consider possible mechanisms.
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ranking = 0.0086629529384443
keywords = hyperostosis
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25/30. Lumbar spinal stenosis in a patient with diffuse idiopathic skeletal hypertrophy syndrome.

    Lumbar spinal stenosis is associated with a variety of conditions, including dysplastic narrowing of the spine, lumbar spondylosis, Paget's disease, and achondroplastic dwarfism. No case of lumbar stenosis associated with diffuse idiopathic skeletal hyperostosis (DISH) previously has been described. It would appear that this case could represent either another manifestation of DISH characterized by involvement of the ligamentum flavum or coincidental association with lumbar spondylosis. In either case, physicians treating spinal and skeletal diseases should be aware of potential neurologic complications requiring surgical decompression due to narrowing of the spinal canal in this unusual disorder.
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ranking = 0.0086629529384443
keywords = hyperostosis
(Clic here for more details about this article)

26/30. Peripheral hyperostosis in rheumatoid arthritis in the absence of axial involvement.

    When diffuse idiopathic skeletal hyperostosis (DISH), or Forestier's disease, coexists with rheumatoid arthritis (RA), the radiographic features of RA are characteristically altered and may be diagnostically misleading. Altered findings include the absence of osteoporosis, bony proliferation around erosions, osteophytosis and ankylosis. Previously reported cases of coexistent RA-DISH have all exhibited characteristic spinal hyperostosis. Two cases are discussed which demonstrate that the distinctive peripheral radiographic findings of RA-DISH may occur in the absence of vertebral involvement.
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ranking = 0.051977717630666
keywords = hyperostosis
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27/30. thrombophlebitis complicating sternocostoclavicular hyperostosis.

    Sternocostoclavicular hyperostosis is a recently recognized disease entity of unknown cause. Although the condition bears similarities to Paget's disease, the limited and unique anatomic, clinical, and histologic findings support the hypothesis that this is a separate entity. The case reported satisfies the criteria for sternocostoclavicular hyperostosis and to our knowledge represents the first reported case to be complicated by thrombophlebitis of an upper extremity with predisposing subclavian vein obstruction.
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ranking = 8.8571194103095
keywords = sternocostoclavicular, sternocostoclavicular hyperostosis, hyperostosis
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28/30. Benign pituitary adenoma associated with hyperostosis of the spenoid bone and monocular blindness. Case report.

    The authors describe a case of benign chromophobe adenoma associated with hyperostosis of the lesser wing of the sphenoid bone and monocular blindness in a 38-year-old woman. The endocrinological and radiological evaluations were all suggestive of a meningioma. The diagnosis was established by biopsy of the tumor mass. After orbital decompression and removal of the tumor, the patient was treated with radiation therapy. Her postoperative course was uneventful, and her visual defects remained fixed.
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ranking = 0.043314764692221
keywords = hyperostosis
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29/30. Osseous manifestations of SAPHO (synovitis, acne, pustulosis, hyperostosis, osteitis) syndrome.

    The SAPHO (synovitis, acne, pustulosis, hyperostosis, and osteitis) syndrome includes a complex group of disorders characterized by peculiar bone lesions, most commonly involving the anterior chest wall, and sometimes accompanied by dermatologic manifestations. The clinical and radiographic features of this syndrome are well described, but few studies have examined the histologic features of the bone lesions. We describe the clinical, radiographic, and histologic features of the osseous lesions encountered in eight patients with a clinical diagnosis of SAPHO syndrome. The patients included five female and three male patients ranging in age from 5 to 63 years (mean, 35.3 years). The most common clinical presentation was pain related to the sites of osseous involvement. Two patients also had some form of pustular dermatosis. The radiographic features of the osseous lesions varied but often suggested the possibility of a neoplasm. Nine pathologic specimens were available for review, five from the clavicle, two from the first rib, one from the calcaneus/cuboid, and one from the tibia. The histologic features varied but seemed related to the duration of the patients' musculoskeletal symptoms. Early lesions contained acute inflammation, edema, and prominent periosteal bone formation, histologically indistinguishable from ordinary bacterial osteomyelitis, whereas late lesions demonstrated markedly sclerotic bone trabeculae with prominent marrow fibrosis and only mild chronic inflammation; one of these biopsies appeared virtually identical to Paget's disease. One biopsy was performed after an intermediate duration of symptoms and contained prominent chronic inflammation only. The histologic findings in SAPHO are variable and nonspecific and may depend on the duration of disease, but it is important to recognize the spectrum of histologic changes possible in the syndrome and to realize that clinicopathologic correlation is necessary to avoid misdiagnosis and unnecessary long-term antibiotic therapy.
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ranking = 0.043314764692221
keywords = hyperostosis
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30/30. Schnitzler's syndrome: report of a new case and a review of the literature.

    schnitzler syndrome is a rare condition characterized by chronic non-pruritic urticaria, recurrent fever, bone pain, osteocondensation, and monoclonal IgM gammopathy without features of lymphoproliferative disease. We describe the case of a 44-year-old man with an 8-year history of bone pain with hyperostosis and a 5-year history of chronic non-pruritic urticaria, associated with fever, hyperleukocytosis, hepatomegaly, serum monoclonal IgM-kappa. Systemic treatment with steroids was effective against bone pain but was ineffective in controlling the urticaria. We also review 35 cases. No adequate treatment has yet been found. The pathogenesis is unclear and the role of the IgM component in the induction of urticaria has not been established.
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ranking = 0.0086629529384443
keywords = hyperostosis
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