Cases reported "Bowen's Disease"

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1/6. Bowen's diseases and basal cell carcinomas in a patient.

    bowen's disease is a well-known precancerous lesion, in which invasive squamous carcinoma may develop. However, it is rare that bowen's disease, basal cell carcinoma, and internal malignancy develop in a single patient. We report a case of a 54-year-old male patient with bowen's disease, basal cell carcinoma of the skin, and squamous cell carcinoma of the lung. Multiple scaly erythematous patches had developed several years earlier and were diagnosed as bowen's disease by skin biopsy. The number of lesions increased and, five months ago, a right lower lobectomy was done for squamous cell carcinoma which was detected on a chest X-ray. skin biopsies of two different sites revealed bowen's disease and basal cell carcinoma. The arsenic level was increased in his hair specimen. cryotherapy was applied.
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2/6. Bowen disease associated with porokeratosis of Mibelli.

    A 73-year-old woman developed Bowen precancerous dermatosis in an area of porokeratosis of Mibelli on her leg. This is the fourth reported case of Bowen disease arising from porokeratosis of Mibelli. The recent literature indicates that porokeratosis of Mibelli may be due to an abnormal clone of cells, predisposing affected individuals to development of malignant neoplasms over the involved areas.
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3/6. bowen's disease of the nail.

    We present a case of bowen's disease of the nail bed in a 60-year-old male. This case should remind us to biopsy any chronic lesion of the nail in order to reduce the delay in diagnosis. Indeed bowen's disease of the nail unit often presents as a clinically misleading 'benign' lesion. early diagnosis is important as this precancerous lesion appears to have a more aggressive behavior when it affects the nail unit. bowen's disease of the nail is therefore considered as a squamous cell carcinoma, and both entities are grouped under the term 'epidermoid carcinoma'. Surgical excision is the first treatment option for those tumors without bone involvement. Our patient was treated with Mohs' micrographic surgery which is considered the ideal surgical treatment as it ensures a complete eradication of the tumor in over 90% of the cases but also maximally preserves normal tissue and function. This case illustrates the challenge of Mohs' surgery on the nail unit due to its particular anatomy and histology.
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keywords = precancerous
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4/6. bowen's disease, Paget's disease, and malignant melanoma in situ.

    The histologic differential diagnosis of skin lesions characterized by large, atypical, clear cells in the epidermis includes bowen's disease, Paget's disease (mammary and extramammary), malignant melanoma in situ (pagetoid precancerous melanosis), mycosis fungoides, Spitz nevus, and artifact. Our experience with these lesions indicates that these diseases can be differentiated immunohistologically by the standard peroxidase-antiperoxidase technique, using antibodies directed against keratin (KER), carcinoembryonic antigen (CEA), and S-100 protein (S-100). Based on a study of 11 cases of bowen's disease, eight cases of Paget's disease, and nine cases of malignant melanoma in situ, we conclude that the atypical clear cells of bowen's disease stain only with antibodies to KER; those of Paget's disease, exclusively with antibodies to CEA; and those of malignant melanoma in situ, with antibodies to S-100. Additionally, we report a case in which clinical and histologic findings suggested bowen's disease, but immunohistologic findings supported the diagnosis of Paget's disease.
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keywords = precancerous
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5/6. Perianal bowen's disease associated with anorectal warts: a case report.

    The occurrence of anogenital warts has increased both in clinic and in private practice. Both sexes and all races are affected, with the highest prevalence in patients aged 15 to 40 years. The etiologic agent, the human papillomavirus (HPV), has been classified by dna hybridization techniques into at least 42 types, of which types 16 and 18 are considered to carry a high risk for cancer. A patient who had been seen intermittently over a period of 26 years with perianal and anal warts that responded to treatment finally developed two granulomatous nodules morphologically different from the previous lesions. A biopsy confirmed that the nodules were typical of bowen's disease, a precancerous lesion, and they were surgically excised. Thus, anogenital warts that fail to respond to conventional therapy or change in appearance warrant a biopsy and, where the technique is available, dna typing to identify the viral pathogen.
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keywords = precancerous
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6/6. bowen's disease of shaft of penis. Successful treatment with 5-fluorouracil.

    bowen's disease is a precancerous lesion of the superficial layers of the skin. The topical application of 5-fluorouracil has been successfully used in the treatment of such lesions. An ususual case of bowen's disease of the skin of the penile shaft treated successfully with topical 5-fluorouracil is presented along with a review of different modes of treatment.
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keywords = precancerous
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