Cases reported "Brenner Tumor"

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1/75. Well-differentiated mucinous carcinoma of the ovary and a coexisting brenner tumor both exhibit amplification of 12q14-21 by comparative genomic hybridization.

    Although the coexistence of mucinous ovarian neoplasms and Brenner tumors is well established, the histogenesis and developmental relationship between the two remain unknown. We used comparative genomic hybridization to analyze two such tumors occurring simultaneously, one in each ovary, in a patient. Amplification of 12q14-21 sequences was found in both tumors; in addition, both tumors also had other, different changes, four identified in the brenner tumor and six in the mucinous carcinoma. The occurrence of the same genetic alteration in both tumors in this woman suggests that the mucinous carcinoma and brenner tumor may be clonally related, i.e., one arose from the other by means of metastatic spreading of transformed cells from one ovary to the other. An alternative explanation is that some unknown, putative tumorigenic agent induced similar and synchronous pathogenetic changes in the epithelium of both ovaries. The phenotypic differences between the tumors are presumably attributable to the other unique genetic abnormalities identified in both tumor types. ( info)

2/75. Malignant Brenner tumors of the ovary and tumor markers: case reports.

    We investigated the tumor marker for malignant Brenner tumors, which had not been established because of the rarity and variable histological criteria. Representative areas of two cases of malignant brenner tumor were investigated by means of the peroxidase-antiperoxidase method using monoclonal antibody to CA125 and CA72-4 antigen and the streptavidin-biotin immunoperoxidase complex method using monoclonal antibody to SCC antigen. Based on clinical course and immunohistochemical studies, serum CA125 and CA72-4 for Case 1 and SCC and CA72-4 for Case 2 were appropriate tumor markers for the establishment of the extent of tumor burden before treatment and to monitor the response to therapy. The discrepancy of the tumor markers of the two present cases is considered to be a reflection of the difference in the malignant component of these cases. However, serum CA72-4 was an appropriate tumor marker for both malignant Brenner tumors. ( info)

3/75. An unusual case of malignant brenner tumor in association with low-grade urothelial carcinoma of the urinary bladder. A case report.

    We present a case of a 45-year-old Caucasian female with a malignant brenner tumor arising at the site of the right ovary 21 years after right adnexectomy performed for ectopic pregnancy. Several months after the presentation of the malignant brenner tumor the patient was diagnosed with low-grade urothelial carcinoma of the urinary bladder. All clinical, biochemical, and pathological findings with the emphasis on the differential diagnosis are summarized. A brief survey of histological theories and classification of Brenner tumors as well as therapeutic approaches with their results are given. We have found a few papers [1, 2] dealing with the coexistence of Brenner tumors with urothelial ones, but to our knowledge the coexistence of both malignant tumors has not been published previously. ( info)

4/75. Malignant brenner tumor mimicking a primary squamous cell carcinoma of the cervix.

    An 86-year-old female presented with a necrotic cervical mass that was biopsy-proven squamous cell carcinoma. She had an elevated CA-125 and a pelvic mass. At surgery, this mass was found to be of adnexal origin and contiguous with the cervix. histology showed a malignant brenner tumor with abundant squamous differentiation eroding the cervix and simulating a primary cervical malignancy. We describe this case and review the literature on metastatic tumors to the cervix. ( info)

5/75. Signet ring stromal tumor of the ovary occurring in conjunction with brenner tumor.

    OBJECTIVE: A case is presented of a single ovarian mass that had elements of both signet ring stromal tumor of the ovary and brenner tumor. methods: The histologic features and the results of histocytochemical, immunohistochemical, and electron microscopic studies are presented. RESULTS: The signet ring component of the mass demonstrated features consistent with the few other cases previously reported. A positive immunohistochemical stain for the peptide hormone inhibin provides additional evidence for an ovarian stromal origin for this tumor. CONCLUSION: The tumor produced no hormonally related symptoms and has shown no evidence of recurrence. Signet ring stromal tumor of the ovary is an uncommon benign tumor that may be confused with metastatic signet ring carcinoma. The significance of the signet ring cells is not certain. Their association with brenner tumor has not been previously described. ( info)

6/75. luteinizing hormone receptor expression in leiomyomatosis peritonealis disseminata.

    BACKGROUND: leiomyomatosis peritonealis disseminata has been attributed to estrogen stimulation and is seen only rarely in postmenopausal women. In such cases, pathogenesis is uncertain. CASE: leiomyomatosis peritonealis disseminata tumors were resected from a postmenopausal woman. She was receiving tamoxifen therapy for breast cancer and had bilateral ovarian Brenner tumors. Estrogen and progesterone receptors were detected. Immunohistochemical analysis indicated that LH receptors were present. CONCLUSION: luteinizing hormone receptors were identified in leiomyomatosis peritonealis disseminata in one woman. Levels of FSH and LH increase after menopause, and immunohistochemical analysis showed the presence of LH receptors, so gonadotropin rather than estrogen stimulation might have contributed to development of leiomyomatosis peritonealis disseminata in this uncommon case. ( info)

7/75. Differential diagnosis, prognostic factors, and clinical treatment of proliferative brenner tumor of the ovary.

    Brenner tumors are rare ovarian tumors displaying benign, borderline or proliferative, and malignant variants. The case of a 63-year-old woman with a proliferative brenner tumor is presented and the histomorphological differential diagnosis of this tumor entity is compared to that of its benign and malignant counterparts. light microscopy, immunohistochemistry, and electron microscopy were performed to allow discrimination from the other subtypes. Despite a considerable overlap of pathological features the differential diagnosis of proliferative brenner tumor could be established. Electron microscopy allowed assessment of characteristic infoldings of the nuclear membrane that proved to be a valuable ultrastructural criterion. Considering that the vast majority of Brenner tumors are benign, precise identification of the small proportion of malignant tumors allows the extent of surgical therapy to be adapted. ( info)

8/75. Transitional cell carcinoma of the endometrium associated with a benign ovarian brenner tumor: a case report.

    Transitional cell carcinomas (TCCs) of the endometrium are rare, and only 10 cases have been described to date. We report the case of a 46-year-old woman who developed both a TCC of the endometrium and a benign ovarian brenner tumor. Such an association has not yet been reported in the literature. Immunohistochemical studies of the uterine tumor showed cytokeratin 7 positivity and cytokeratin 20 negative staining, which was consistent with a Mullerian derivation. Human papilloma virus (HPV) immunostaining as well as polymerase chain reaction (PCR) analysis using primers for HPV types 6, 11, 16, and 18 failed to detect viral dna. The coexistence of a TCC of the endometrium and an ovarian brenner tumor might be coincidental but raises the possibility of a field effect, as seen with multifocal endometrioid tumors or multiple urinary tract TCCs. ( info)

9/75. magnetic resonance imaging of a benign brenner tumor with an ipsilateral simple cyst.

    magnetic resonance imaging features were assessed in a benign brenner tumor with an ipsilateral simple cyst. brenner tumor showed isointensity to the uterine muscle on T1-weighted images and markedly low signal intensity on T2-weighted images. On the other hand, on T1-weighted images after administration of gadopentetate dimeglumine a brenner tumor showed mild patchy enhancement. The low signal intensity seen on T1- and T2-weighted images may have been due to the abundant dense fibrous tissues. ( info)

10/75. leiomyomatosis peritonealis disseminata and ovarian brenner tumor associated with tamoxifen use.

    tamoxifen is frequently administered as adjuvant therapy for breast carcinoma and produces weak estrogen agonist effects in estrogen sensitive tissues. In addition to producing a measurable increase in the risk of endometrial carcinoma, tamoxifen has also been associated with increasing size of uterine leiomyomata as well as the development of new leiomyomata. As the indications for tamoxifen therapy expand, surveillance for additional potential associated adverse outcomes is warranted. A 44-year-old woman with a history of bilateral breast carcinoma presented with leiomyomatosis peritonealis disseminata and a right ovarian brenner tumor 18 months after beginning adjuvant tamoxifen therapy. Although a causal link cannot be proven, this case is the second reported association between leiomyomatosis peritonealis disseminata, an ovarian brenner tumor, and tamoxifen use for the treatment of breast carcinoma. Given the hormonal sensitivity of leiomyomatosis peritonealis disseminata, both mutagenic and mitogenic effects of tamoxifen on this rare entity must be considered. In the setting of continued hormonal treatment for breast carcinoma, the management of leiomyomatosis peritonealis disseminata presents unique clinical challenges. ( info)
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