Cases reported "Candidiasis"

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1/37. Surgical management of necrotizing Candida esophagitis.

    Invasive esophageal candidiasis produced transmural necrosis leading to perforation in 2 patients aged 10 and 27 years. Both patients survived after esophageal resection and complete diversion. One patient with acute leukemia and neutropenia experienced systemic candidiasis, which resolved after esophagectomy. esophagectomy and diversion for yeast-induced necrosis may lead to complete recovery and resolution of disseminated candidiasis when combined with systemic antifungal therapy.
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keywords = esophagitis
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2/37. Esophageal candidoma in a patient with acquired immunodeficiency syndrome.

    Oral thrush and esophagitis caused by Candida are common in patients infected with the human immunodeficiency virus. We present the case of a 33-year-old man with acquired immunodeficiency syndrome who developed dysphagia during a hospitalization for pneumonia. signs and symptoms were consistent with Candida esophagitis. Despite therapy with fluconazole, the patient's symptoms persisted. At upper endoscopy, a 1-cm, polypoid esophageal mass at 30 cm from the incisors and several other nodular lesions were observed; white plaques were noted throughout the esophagus. biopsy specimens of the mass contained hyphal forms consistent with Candida species. Therapy with amphotericin b improved the patient's symptoms, and resolution of the mass was confirmed by repeat upper endoscopy. We believe this is the first case in the medical literature of a Candida mass (candidoma) causing dysphagia in a patient with acquired immunodeficiency syndrome. Candidoma should be considered in the differential diagnosis of dysphagia in patients with human immunodeficiency virus infection or immunosuppression due to other causes.
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ranking = 0.5
keywords = esophagitis
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3/37. Monilial esophagitis.

    A case of monilial esophagitis, developing in a diabetic patient treated with gentamicin for escherichia coli septicemia, is described. The esophagogram was normal and the diagnosis was confirmed by fiberoptic esophagoscopy and biopsy examination. The patient responded to oral nystatin. The literature on esophageal moniliasis is reviewed.
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ranking = 1.25
keywords = esophagitis
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4/37. Candida oesophagitis with hepatitis C virus: an uncommon association.

    Candida oesophagitis is an acquired immune deficiency syndrome (AIDS)-defining illness. We report a 28-year-old woman who presented with Candida oesophagitis with underlying chronic hepatitis C. The patient presented with anorexia and weakness and was noted to have raised serum transaminases. Upper-gastrointestinal endoscopy revealed Candida oesophagitis involving the whole oesophagus. Oesophageal biopsy demonstrated changes consistent with Candida oesophagitis. serology was positive for hepatitis c antibodies, and polymerase chain reaction (PCR) genotyped hepatitis C virus (HCV) as genotype 3. liver biopsy revealed chronic hepatitis with moderately active portal inflammation. A human immunodeficiency virus (hiv) test was non-reactive for types 1 and 2. The development of Candida oesophagitis in a patient with chronic HCV infection demands prompt consideration of general debility and immunosuppression as effects of HCV that led to an occurrence of opportunistic infection. Evaluation of this case provides insight into various mechanisms of immune suppression associated with HCV infection.
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ranking = 2.25
keywords = esophagitis
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5/37. Caspofungin resistance in candida albicans: correlating clinical outcome with laboratory susceptibility testing of three isogenic isolates serially obtained from a patient with progressive Candida esophagitis.

    A patient with azole-refractory thrush-esophagitis responded initially to caspofungin, but the treatment eventually failed. In a murine model, caspofungin was effective against two early isolates for which the MICs of caspofungin were low, but it was less effective against a late isolate for which the MIC of caspofungin was greater. We concluded that there is a correlation between in vivo failure and rising in vitro caspofungin MICs.
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ranking = 1.25
keywords = esophagitis
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6/37. Russell body gastritis: an unusual, tumor-like lesion of the gastric mucosa.

    The case of an 80-year-old woman who presented with epigastric symptoms is reported. Upper gastrointestinal endoscopy displayed Candida esophagitis and a localized swelling of the fundic mucosa. Histologic examination of the gastric biopsy showed a distinctive accumulation of numerous uniform plasma cells filled with so-called Russell bodies. On low-power view, the lesion resembled a neoplastic process due to the marked expansion of the lamina propria with distension of fundic glands. However, immunohistochemistry confirmed a polyclonal pattern of the plasma cells. This unusual reactive lesion of the gastric mucosa has only rarely been described and has been termed Russell body gastritis.
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ranking = 0.25
keywords = esophagitis
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7/37. Successful treatment of Candida infections in peritoneal dialysis patients: case reports and review of the literature.

    Infections with Candida species have been associated with significant morbidity and mortality in peritoneal dialysis (PD) patients. Such infections include peritonitis and exit-site infections attributable to Candida species, disseminated candidiasis in immunocompromised patients, and Candida esophagitis. In peritonitis and exit-site infections, both success and failure have been reported with commercially available medications. In disseminated candidiasis and Candida esophagitis, successful treatment and patient recovery depend on the overall nutritional and immune state of the patient. One case each of peritonitis and exit-site infection with non candida albicans species were successfully treated with oral voriconazole. No literature currently exists on the use of this new product in dialysis patients. Presented here is a treatment strategy that resulted in maintenance of PD in the home setting and catheter survival following completion of treatment. A review of the English-language literature shows mixed outcomes associated with continuation of PD during treatment for Candida infection in PD patients. In conclusion, a commercially available product can be used to successfully treat PD patients who have Candida infections and to maintain the PD catheter for PD.
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ranking = 0.5
keywords = esophagitis
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8/37. Intense esophageal FDG activity caused by Candida infection obscured the concurrent primary esophageal cancer on PET imaging.

    Esophageal cancer frequently causes a focal intense FDG uptake on positron emission tomography (PET) imaging while esophagitis often results in a mild to moderate degree of FDG activity in a diffuse pattern. However, detection of an esophageal cancer can become difficult in the presence of a diffuse esophageal activity because of esophagitis. We present such case in which esophageal cancer superimposed by Candidal esophagitis is difficult to recognize on FDG PET images.
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ranking = 0.75
keywords = esophagitis
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9/37. Progressive loss of echinocandin activity following prolonged use for treatment of candida albicans oesophagitis.

    OBJECTIVES: To illustrate the progressive loss of cross-echinocandin activity on candida albicans isolates with strong clonal homology from a patient with advanced hiv infection and chronic oesophagitis progressively resistant to uninterrupted micafungin treatment. methods: Antifungal susceptibility profiles for different antifungal agents were determined against serial C. albicans isolates retrieved before and during therapy. Multilocus sequencing typing (MLST) was performed on each of the isolates. FKS1 mutations conferring reduced susceptibility to echinocandin drugs were determined by dna sequence analysis. RESULTS: Four C. albicans isolates showing identical allelic homology were retrieved from the patient at the initiation and during therapy with micafungin. The progressive lack of clinical response to micafungin therapy was associated with increased MICs of all three echinocandin drugs (caspofungin, micafungin and anidulafungin) in association with the acquisition of mutations in the FKS1 gene. CONCLUSIONS: This report documents for the first time a progressive loss of activity of all three echinocandin drugs against clonally related C. albicans isolates following long-term clinical exposure to this new class of antifungal agents.
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ranking = 1.25
keywords = esophagitis
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10/37. gastrointestinal hemorrhage due to gastrointestinal mycobacterium avium intracellulare or esophageal candidiasis in patients with the acquired immunodeficiency syndrome.

    A 33-yr-old black intravenous drug abuser with the acquired immunodeficiency syndrome (AIDS) had a massive fatal upper gastrointestinal hemorrhage due to profound and diffuse esophageal ulceration from Candida, as demonstrated by postmortem examination. A 2-yr-old white male with congenitally acquired AIDS had a massive fatal esophageal bleed as a result of esophagitis from candida albicans, as proven by pathologic examination and culture of endoscopic biopsies. A 27-yr-old black human immunodeficiency virus-seropositive female died from massive lower gastrointestinal bleeding due to extensive small and large intestinal ulceration caused by mycobacterium avium intracellulare, as proven by microscopic examination and mycobacterial culture of intestinal tissue. These reports extend the clinical spectrum of these infections in AIDS patients by demonstrating that these infections can produce gastrointestinal bleeding.
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ranking = 0.25
keywords = esophagitis
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