Cases reported "Carcinoma, Renal Cell"

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11/442. Acrometastasis in renal cell carcinoma.

    Acrometastasis is rare and may occur as the primary manifestation of an occult malignant tumor. Clinically, it may mimic benign osteoarthritic diseases, thus resulting in misdiagnosis and improper treatment. We describe a patient with renal cell carcinoma that presented itself as a case of chronic osteomyelitis after trauma to a finger. Such a lesion presents diagnostic challenges to both clinicians and histopathologists.
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keywords = metastasis
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12/442. Successful treatment of metastatic renal cell carcinoma with a nonmyeloablative allogeneic peripheral-blood progenitor-cell transplant: evidence for a graft-versus-tumor effect.

    PURPOSE: A 50-year-old man developed progressive pulmonary metastasis resistant to interferon alfa-2b treatment 7 months after he underwent left nephrectomy for stage III renal cell carcinoma. We performed a nonmyeloablative allogeneic peripheral-blood stem-cell transplant in this patient to exploit a possible graft-versus-tumor effect from allogeneic lymphocytes. MATERIALS AND methods: The conditioning regimen consisted of fludarabine and cyclophosphamide followed by a T-cell replete, granulocyte-colony stimulating-factor-mobilized peripheral-blood stem-cell transplant from his HLA-identical brother. cyclosporine was administered from days -4 to 45 to prevent graft rejection and acute graft-versus-host disease (GVHD). RESULTS: Serial polymerase chain reaction analysis of hematopoietic lineage-specific minisatellites initiallyshowed mixed chimerism in CD14( ) and CD15( ) myeloid cells, CD3( ) T cells, and CD34( ) progenitor cells, with rapid conversion to 100% donor T-cell chimerism by day 60 and 100% donor myeloid cells by day 100. Serial computed tomography scans of the chest showed stable disease at day 30, slight regression of pulmonary lesions at day 63, and complete disappearance of all pulmonary metastatic disease by day 110. Mild transient acute GVHD disease of the skin occurred on day 60 and limited chronic GVHD of the skin occurred by day 200. CONCLUSION: The complete regression of metastatic disease, which has now been maintained for more than 1 year, is compatible with a graft-versus-tumor effect.
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ranking = 0.2
keywords = metastasis
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13/442. Cytologic diagnosis of vaginal metastasis from renal cell carcinoma. A case report.

    BACKGROUND: Metastasis of renal cell carcinoma to the vagina is rare, although it may be the first evidence of the existence of the primary tumor. CASE: A metastatic deposit of renal cell carcinoma in the vagina was diagnosed by cytology as clear cell adenocarcinoma, which was confirmed by biopsy. Radiographic and ultrasound examinations confirmed the renal site of origin, which was corroborated by immunohistochemistry of the biopsy specimen. CONCLUSION: When a cytologic diagnosis of vaginal clear cell adenocarcinoma is made, metastasis of renal cell carcinoma should be considered in the differential diagnosis.
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keywords = metastasis
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14/442. Pancreatic metastasis from clear cell renal carcinoma: diagnosis with chemical shift MRI.

    Some clear cell renal cell carcinomas contain intracellular lipid, which can be detected with chemical shift MRI. We present an example of surgically proven metastatic clear cell renal carcinoma to the pancreas, which was diagnosed using chemical shift MRI.
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ranking = 0.8
keywords = metastasis
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15/442. pancreaticoduodenectomy for metastatic renal cell carcinoma: report of a case.

    Metastasis to the pancreas from a distant primary cancer is uncommon, most cases being detected in the advanced stages of disease, often multiple in number, and diffusely displayed beyond surgical salvage. A solitary metastasis in the head of the pancreas is rarely encountered and although potentially amenable to surgical resection, surgeons are hesitant to perform pancreaticoduodenectomy for metastatic disease. Renal cell carcinoma is one malignancy with a propensity to metastasize to the pancreas. We report herein the case of a solitary pancreatic metastasis from renal cell carcinoma successfully treated by pancreaticoduodenectomy in a middle-aged man. A discussion on the indications and effectiveness of performing pancreaticoduodenectomy for metastatic renal cell carcinoma is also presented.
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ranking = 0.4
keywords = metastasis
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16/442. Colonic metastasis from renal cell carcinoma: helical-CT demonstration.

    Clinically evident colonic metastasis from renal cell carcinoma (RCC) is rare. In the present study a hypervascular sigmoid mass was demonstrated on arterial-phase helical CT using a water enema in a patient who had suffered left nephrectomy 8 years previously for RCC. The intense and early enhancement of the lesion suggested the possibility of a solitary colonic metastasis from RCC, a diagnosis which was pathologically confirmed.
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ranking = 1.2
keywords = metastasis
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17/442. The role of surgery in renal cell carcinoma with solitary metachronous metastasis to contralateral adrenal gland.

    We report a case of renal cell carcinoma with solitary metachronous metastasis to contralateral adrenal gland occurring 9 months after radical nephrectomy. The patient was treated with a contralateral adrenalectomy and is alive for 87 months. The literature was reviewed and 5-year survival of solitary metachronous metastasis to contralateral adrenal gland was 60%. Follow-up duration of our case was the longest in the literature. It is suggested that the solitary contralateral adrenal gland metastasis of renal cell carcinoma should be resected since there is no effective treatment of metastatic renal cell carcinoma. Good prognosis may be then and the good be expected.
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ranking = 1.4
keywords = metastasis
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18/442. Pyelic metastasis from a renal cell carcinoma following partial nephrectomy.

    The majority of ureteropelvic metastatic tumors are of non-urologic origin. A case of metastatic clear cell adenocarcinoma to the renal pelvis in a patient with a bilateral, asynchronous renal tumor is presented. Conservative surgical treatment involved open pyelotomy and local resection of the tumor. At the 12-month follow-up, the patient is alive, asymptomatic and not on dialysis. The hypothesis for the mechanisms of dissemination and the relevance of conservative treatment are discussed.
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ranking = 0.8
keywords = metastasis
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19/442. Solitary metachronous splenic metastases: an evaluation of surgical treatment.

    Splenic metastases occurring after primary tumor removal and apparently solitary have been documented only recently in literature. They are, most of the times, clinically asymptomatic and their presence is casually determined by ultrasonographic follow-up in subjects otherwise in good conditions. The belief that splenic metastases occur only in disseminated cancer is today no longer accepted. Some Authors consider solitary splenic metachronous metastases eligible for surgical treatment as well as pulmonary or hepatic metastases. In the case presented, surgery was required due to abscess formation of a splenic metastasis, which was not responding to chemotherapy. Our experience, like others reported in literature, verified a long-term post-operative survival in spite of limited disease-free time. Surgical treatment by splenectomy can be indicated in selected patients, considering that chemotherapy has been proved to be ineffective in the treatment of splenic metastases.
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ranking = 0.2
keywords = metastasis
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20/442. Solitary metachronous contralateral adrenal metastasis from renal cell carcinoma.

    Malignant involvement of the contralateral adrenal gland in cases of renal cell carcinoma is extremely rare. We report a case of solitary metachronous contralateral adrenal metastasis occurring 7.5 years after radical nephrectomy. The metastasis was treated with adrenalectomy and steroid replacement. Thirty months later, the patient remained without evidence of disease. This very rare presentation can prove to be a diagnostic challenge. Appropriate aggressive surgical treatment is warranted.
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ranking = 1.2
keywords = metastasis
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