Cases reported "Carcinoma"

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11/17. Autonomic neuropathy and hypertrophic osteoarthropathy in association with malignancy.

    A case of autonomic neuropathy and hypertrophic osteoarthropathy in association with metastatic giant cell carcinoma of the lung and leiomyosarcoma of the stomach is reported. The link between these conditions is discussed and the role of pancreatic polypeptide as a possible marker for hypertrophic osteoarthropathy reported.
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ranking = 1
keywords = osteoarthropathy
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12/17. blood-borne spread of a benign giant cell tumor from the radius to the soft tissue of the hand.

    A unique case of giant cell tumor of the distal epiphysis of the radius that spread to the soft tissue of the hand after an en bloc excision is reported. Three months after the excision, 27 cutaneous-subcutaneous tumoral nodules, ranging from 0.3 to 1.5 cm in diameter, were observed spreading from wrist to fingers on both hand aspects. Microscopically, the tumor tissue displayed the pattern of a benign giant cell tumor. Multiple tumor tissue emboli were lodged in venules of the soft tissue between nodules and in a small vein. The findings suggest that the tumor emboli arrived at the hand through a mechanism of retrograde embolism through the superficial veins.
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ranking = 2.8015423417377E-5
keywords = finger
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13/17. Hypertrophic pulmonary osteoarthropathy: response to chemotherapy without documented tumour response.

    A case is reported of severe hypertrophic pulmonary osteoarthropathy associated with bronchogenic carcinoma which successfully responded to chemotherapy, despite the fact there was no objective response in the primary lesion. Previous treatment and responses are briefly reviewed. The method or methods by which chemotherapy may alleviate HPOA in the absence of response to the primary lesion are discussed. The marked discrepancy between progression of the HPOA and progression of the clubbing is noted. The fact that HPOA is potentially treatable despite the prognosis of the primary is emphasised.
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ranking = 0.83333333333333
keywords = osteoarthropathy
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14/17. Hypertrophic pulmonary osteoarthropathy and its occurrence with pulmonary metastases from renal carcinoma.

    The literature of hypertrophic pulmonary osteoarthropathy is reviewed with special reference to its occurrence with pulmonary metastases from extrathoracic tumours. The present theories on aetiology are discussed, and the relationship to finger clubbing and bronchogenic carcinoma is reviewed. A case is reported of hypertrophic osteoarthropathy as the presenting feature of pulmonary metastases from renal carcinoma, and of its relief by pulmonary resection.
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ranking = 1.0000280154234
keywords = osteoarthropathy, finger
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15/17. Hypertrophic osteoarthropathy in childhood malignancy.

    Hypertrophic osteoarthropathy (HOA), well known in adults, is rarely encountered in children. The clinical features include clubbing of the fingers and toes, arthritis, and a sometimes painful ossifying periostitis of the tubular bones. Apart from a hereditary form (primary HOA), most of the cases encountered in children are secondary and associated with conditions such as chronic suppurative lung processes (e.g., cystic fibrosis), congenital heart disease, biliary atresia, and polyposis coli. The association with malignant disorders, which is relatively common in adults, is very rare in children. In 1986 the authors published a case report of a patient with carcinoma of the nasopharynx who developed HOA. Another similar patient has been encountered. In both, the appearance of HOA was associated with a very poor prognosis. A meticulous research of the literature from 1890 to 1990 revealed only 24 children (19 boys, 5 girls) under the age of 18, with malignancy and associated HOA. Among them were 10 patients with a carcinoma of the nasopharynx, 8 with osteosarcoma, 3 with Hodgkin's lymphoma, 1 with a periosteal sarcoma, 1 with mesothelioma of the pleura, and 1 with carcinoma of the thymus. In five patients with HOA, there were no abnormalities of the lungs, mediastinum, or pleura, and none developed during the course of the disease. Many authors mention the predictive value of HOA, especially in association with malignant tumors. In contrast to suppurative processes in the lungs, in those with neoplastic disease involving the chest, HOA may precede pulmonary symptoms by 1-18 months. A striking feature of HOA in these instances is the reversibility of the complaints after successful treatment of the disorder of the chest, both in benign and malignant conditions. The present case is the second reported by the authors and the first description of a girl with carcinoma of the nasopharynx developing HOA.
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ranking = 0.83336134875675
keywords = osteoarthropathy, finger
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16/17. radiotherapy for extreme hypertrophic pulmonary osteoarthropathy associated with malignancy.

    A patient with florid hypertrophic pulmonary osteoarthropathy (HPOA) associated with metastatic nasopharyngeal carcinoma is presented. Despite the presence of metastatic disease in the thorax and in bone, the patient's main symptom was severe pain from the HPOA, which was temporarily relieved by chemotherapy. Her disease subsequently progressed during chemotherapy and the pain became resistant to conventional treatment, including high dose morphine, non-steriodal anti-inflammatory agents and steriods. It was only with local radiation to the involved joints that the pain could be controlled. Our patient demonstrates that local radiotherapy is an option for the palliation of extreme HPOA.
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ranking = 0.83333333333333
keywords = osteoarthropathy
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17/17. Hypertrophic osteoarthropathy--an important differential diagnosis.

    A case of hypertrophic osteoarthropathy associated with carcinoma of the lung is presented. The symptomatology of the former usually dominates the clinical picture so that early diagnosis of the underlying carcinoma often depends on recognition of hypertrophic osteoarthropathy. A brief review of the literature is given.
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ranking = 1
keywords = osteoarthropathy
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