11/17. Focal glial differentiation and oncocytic transformation in choroid plexus papilloma.The histiopathological features of a choroid plexus papilloma in a 27-year-old male are described. The tumor displayed marked oncocytic transformation and glial differentiation of the epithelium in areas in which there was also marked sclerosis of the fibrovascular cores. Non-membrane-bound bodies of intermediate filaments characterized ultrastructurally the cells with glial differentiation.- - - - - - - - - - ranking = 1keywords = sclerosis (Clic here for more details about this article) |
12/17. Diagnostic problems in multiple sclerosis. Two cases with clinical diagnosis of MS showing only a diffusely growing malignant astrocytoma.Two cases are presented with a long clinical history of multiple sclerosis (MS) before the diagnosis of an intracranial brain tumor. In the subsequent brain autopsy, however, both cases presented a diffusely growing anaplastic astrocytoma, only, and no changes similar to MS were seen. Diffuse tumor growth was noted in periventricular brain tissue and extended down to pons or medulla. Immunohistochemically, a positive staining for glial fibrillar acidic protein was observed in both cases and in the second case, which presented an increased amount of cerebrospinal fluid IgG, also a positive staining for immunoglobulins was seen. These case histories and subsequent neuropathological findings are presented as examples of diagnostic difficulties in MS, especially in cases with diffusely growing gliomas.- - - - - - - - - - ranking = 5keywords = sclerosis (Clic here for more details about this article) |
13/17. Giant cell astrocytoma in tuberous sclerosis: computed tomographic findings.Clinical presentation and computed tomography (CT) findings in four tuberous sclerosis patients with large ventricular tumours situated near the foramina of Monro, and causing obstructive hydrocephalus are described. These tumours (so-called giant cell astrocytomas) demonstrated uniform post-contrast enhancement. This finding, along with their location, distinguished them from the much commoner cortical and subependymal tubers of tuberous sclerosis.- - - - - - - - - - ranking = 6keywords = sclerosis (Clic here for more details about this article) |
14/17. Subependymal giant-cell astrocytoma. Case report with ultrastructural study.A 13-year-old boy presented with an obstructive left lateral intraventricular mass. Pathological examination revealed a subependymal giant-cell astrocytoma. Further clinical investigation confirmed the diagnosis of tuberous sclerosis. Ultrastructural examination confirmed previously reported features of this tumor. Tumor cells containing large dense granulated bodies and dense-core vesicles, not previously described in this tumor, were identified.- - - - - - - - - - ranking = 1keywords = sclerosis (Clic here for more details about this article) |
15/17. Bilateral internuclear ophthalmoplegia associated with fourth ventricular epidermoid tumor. Case report.A 49-year-old woman with multiple sclerosis diagnosed by her classical clinical history and bilateral internuclear ophthalmoplegia was found to have an epidermoid tumor of the fourth ventricle. Removal of the tumor resulted in resolution of her neurological symptoms and signs.- - - - - - - - - - ranking = 1keywords = sclerosis (Clic here for more details about this article) |
16/17. Subependymal giant cell astrocytoma with tuberous sclerosis--case report.tuberous sclerosis is a rare disease of autosomal dominant inheritance and may affect any organ, and less than 2% have a subependymal giant cell astrocytoma. In the present report, a 6-year-old girl with clinical features of tuberous sclerosis had an intraventricular tumor. CT scan and MRI of brain showed a tumor in the lateral ventricles extended into the Foramina of Monro and third ventricle causing severe hydrocephalus. She underwent left frontal craniotomy with partial removal of the tumor. The pathology was subependymal giant cell astrocytoma. Patient's neurological condition improved postoperatively and postoperative CT scan showed no hydrocephalus. Clinical and radiological follow-up of patients with tuberous sclerosis who had subependymal nodules in early childhood is important due to its possibility of subsequent transformation into intraventricular tumor.- - - - - - - - - - ranking = 7keywords = sclerosis (Clic here for more details about this article) |
17/17. glioblastoma following radiotherapy in a patient with tuberous sclerosis.A 26-year-old male with tuberous sclerosis developed a glioblastoma in the right temporal lobe 8 years after surgical excision and irradiation of a subependymal giant cell astrocytoma. The glioblastoma was probably an irradiation-induced tumor. Irradiation should not be given routinely for subependymal giant cell astrocytoma.- - - - - - - - - - ranking = 5keywords = sclerosis (Clic here for more details about this article) |
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