Cases reported "Chondrosarcoma"

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1/7. High-grade extraskeletal myxoid chondrosarcoma: a high-grade epithelioid malignancy.

    AIMS: Extraskeletal myxoid chondrosarcoma is typically a low-to-intermediate grade sarcoma that is associated with a prolonged clinical course. High-grade forms are rare and not well characterized. In this series we report the clinicopathological, immunohistochemical and ultrastructural findings in four cases of high-grade extraskeletal myxoid chondrosarcoma. methods AND RESULTS: The patients were three men and one woman (ages 34-73 years) with tumours located in the thigh (two cases), paraspinal soft tissue and perineum. Three patients had metastases, one at 12 weeks, one at 10 months, and one at presentation of recurrent tumour. In the latter case the original tumour was low grade and became high grade when it recurred 3.5 years later. All three patients died of disease. One patient was lost to follow-up. The most striking histological feature in all four tumours was the presence of numerous large epithelioid cells. These cells were arranged in cords within myxoid matrix and in sheets devoid of matrix. Two tumours had areas of conventional extraskeletal myxoid chondrosarcoma intermixed with the high-grade areas. One tumour showed transition to high-grade spindle cell sarcoma. One tumour had cells with rhabdoid features. Immunohistochemically, two tumours focally expressed S100 protein, and one focally expressed EMA. All were negative with cytokeratin, desmin, smooth muscle actin, HMB45, CD31 and CD34. Ultrastructural features in three cases were compatible with chondrosarcoma; one tumour had aggregates of microtubules within rough endoplasmic reticulum, a characteristic feature of this tumour. CONCLUSIONS: High-grade extraskeletal myxoid chondrosaroma is a rare and aggressive soft tissue sarcoma, and should be included in the differential diagnosis of other epithelioid malignancies.
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keywords = microtubules
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2/7. Extraskeletal myxoid chondrosarcoma characterized by microtubular aggregates in the rough endoplasmic reticulum and tubulin immunoreactivity.

    A case is reported of a 66-year-old female with an extraskeletal myxoid chondrosarcoma which had originated in the lateral region of the right knee. The tumour tissue of the primary, recurrent, and metastatic deposits in the lungs was examined by electron microscopy and immunohistochemistry. Almost all the sarcoma cells in every tumour specimen harboured immunoreactivity to both alpha- and beta-subunits of S-100 protein. A large population of cells in the subcutaneous tumour at autopsy had numerous parallel arrays of microtubules within the rough endoplasmic reticulum in addition to the well-described ultrastructural features indicative of chondroblastic origin. These structures were present in round to polygonal, but not in fibroblastic, tumour cells. tubulin immunoreactivity in the tumour cells showed the same tendency, being frequently positive in the large cells of the subcutaneous tumour but weakly positive in the fibroblastic and medium-sized cells of the recurrent and metastatic tumours. The parallel arrays of intracisternal microtubules therefore may be composed of tubulin protein, as in ordinary cytoplasmic microtubules.
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keywords = microtubules
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3/7. Skeletal myxoid chondrosarcoma with microtubular aggregates within rough endoplasmic reticulum.

    A skeletal myxoid chondrosarcoma of the femur was examined by light and electron microscopy. light microscopic features were characteristic for myxoid chondrosarcoma or "chordoid sarcoma." Electron microscopy disclosed crystalline arrays of microtubules within dilated rough endoplasmic reticulum, a feature previously described in extraskeletal myxoid chondrosarcomas. Tumors with the histologic characteristics of extraskeletal myxoid chondrosarcoma ("chordoid sarcoma") occurring in bone have been rarely reported. We describe herein such a tumor and document the existence of distinct microtubules within the endoplasmic reticulum.
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keywords = microtubules
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4/7. Microtubular aggregates within rough endoplasmic reticulum: an unusual ultrastructural feature of extraskeletal myxoid chondrosarcoma.

    Two extraskeletal myxoid chondrosarcomas were examined by electron microscopy. In addition to the well-described ultrastructural features indicative of chondroblastic origin, both of these chondrosarcomas had unusual parallel microtubules packed within rough endoplasmic reticulum. This paper reviews the differential diagnosis of extraskeletal myxoid chondrosarcoma and discusses ultrastructural examination as a valuable adjunct in the diagnosis of this uncommon soft tissue tumor.
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keywords = microtubules
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5/7. Microtubular aggregates in the rough endoplasmic reticulum of a myxoid chondrosarcoma.

    A tumor with the light microscopic and histochemical characteristics of myxoid chondrosarcoma is examined ultrastructurally. Instead of the usual features of chondroblasts, the tumor cells exhibited prominent collections of long straight microtubules within the endoplasmic reticulum. This finding is compared with other previously reported tubular aggregates. The differential diagnosis and ultrastructure of myxoid chondrosarcoma are also discussed.
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keywords = microtubules
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6/7. Intracisternal microtubular aggregates in classic (non chondroid) chordoma.

    A case of unequivocal and classic (non chondroid) chordoma with cells including microtubular aggregates is reported. Parallel arrays of straight or slightly curved and evenly spaced 22-26 nm microtubules, showing a fine periodicity and without internal structure, were confined within dilated cisternae. These cisternae were characterized by a single layered limiting membrane, without associated ribosomes. This is the second reported occurrence of such microtubules in a spheno-occipital classic chordoma. It emphasizes the nonspecificity of this finding namely in reference to extraskeletal myxoid chondrosarcoma or chondroid chordoma. Furthermore, intracytoplasmic true lumina were found to partly account for the cellular vacuolar character on light microscopy, an observation generally underscored in chordoma cells.
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ranking = 2
keywords = microtubules
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7/7. Extraskeletal myxoid chondrosarcoma with intracisternal microtubules.

    A case of extraskeletal myxoid chondrosarcoma with intracisternal microtubules is presented. The microtubules were generally straight, parallel, closely packed, and evenly spaced, but they did not form geometric arrays. Aggregates of stromalike myxoid material were present in the cisternae and the adjacent cytoplasm. microtubules were never found within the cytoplasm. A similar ultrastructural appearance was seen in 4 of 10 other examples of extraskeletal myxoid chondrosarcoma.
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ranking = 6
keywords = microtubules
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