Cases reported "Choriocarcinoma"

Filter by keywords:



Filtering documents. Please wait...

1/6. Mixed germ cell tumor of the ovary with pure choriocarcinoma metastasis.

    A case report of a 30-month disease-free survival in a ten-year-old girl with ovarian mixed germ cell tumor consisting of dysgerminoma, choriocarcinoma, and immature teratoma with pure choriocarcinoma paraaortic lymph node metastasis is presented. To prevent resistant cell colonies, the noncross-resistant combination of vinblastine-Adriamycin and vinblastine-actinomycin D-cytoxan were added to the initial four courses of vinblastine-cisplatin-bleomycin. There are no previously reported survivals in ovarian mixed germ cell tumors with pure choriocarcinoma metastasis.
- - - - - - - - - -
ranking = 1
keywords = dysgerminoma
(Clic here for more details about this article)

2/6. dysgerminoma with syncytiotrophoblastic giant cells presenting as a hydatidiform mole.

    There have been a total of 11 cases of pure dysgerminoma with syncytiotrophoblastic giant cells (SGC) previously reported in the literature as of June 1981. All were Stage IA, all were treated with unilateral salpingo-oophorectomy, and the preoperative serum human chorionic beta-gonadotropin (beta-hCG) titers ranged from 2000 to 3160 mlU/ml. A recent case at William Beaumont Army Medical Center involved a 20-year-old Hispanic female who presented with a 20 weeks' size pelvic-abdominal mass which was sonographically consistent with a hydatidiform mole. An initial preoperative serum beta subunit hCG was 193,000 mlU/ml. At the time of surgery a Stage IC dysgerminoma of the right ovary was discovered and right salpingo-oophorectomy performed. In reviewing all 11 previously reported cases, not only is this case the first Stage IC reported, but it also is the first to present as a hydatidiform mole, has the highest ever reported preoperative beta-hCG, and provides the first ultrastructural study of this tumor type. The unusual clinical presentation and management of this case are discussed and a brief review of the clinical and pathological features of this unusual tumor is given.
- - - - - - - - - -
ranking = 2
keywords = dysgerminoma
(Clic here for more details about this article)

3/6. Germ cell tumors in monozygous twins with gonadal dysgenesis and 46,XY karyotype.

    Monozygous twin phenotypic females, aged 18, with primary amenorrhea and a 46,XY karyotype and bearing germ cell tumors are described. Patient 1 had a large pelvic tumor involving the uterus, oviduct, and intestine. histology revealed the choriocarcinoma pattern. No ovarian or testicular tissue was identified. The preoperative serologic pregnancy test was positive. After surgery the urinary human chorionic gonadotropin value was 2500 units per 24 hours. The patient died 2 months after the operation despite chemotherapy. Patient 2 was admitted to the hospital for evaluation following the discovery of pelvic tumor in her twin sister. She had 1 streak gonad harboring gonadoblastoma and, on the opposite side, a gonadoblastoma overgrown by dysgerminoma. The patient is well 4 years after surgery. The risk of malignancy in individuals with XY gonadal dysgenesis is emphasized, and examination and confirmation of karyotype of siblings are recommended.
- - - - - - - - - -
ranking = 1
keywords = dysgerminoma
(Clic here for more details about this article)

4/6. Malignant germ cell tumours in two siblings.

    Familial germ cell tumours are well recognised in kinship with gonadal dysgenesis, but their occurrence in siblings with normal chromosomes is rare. We report two sisters who presented within a 4 month period with malignant ovarian germ cell tumours; one a dysgerminoma and the other a mixed tumour with marked choriocarcinomatous elements. Both children had a normal female constitutional karyotype and normal phenotype.
- - - - - - - - - -
ranking = 1
keywords = dysgerminoma
(Clic here for more details about this article)

5/6. Alphafetoprotein and human chorionic gonadotropin determination in cerebrospinal fluid. An aid to the diagnosis and management of intracranial germ-cell tumors.

    The cerebrospinal fluid (CSF) and serum of six patients with histologically verified intracranial germ-cell tumors were assayed serially for the presence of alphafetoprotein (AFP) and the beta subunit of human chorionic gonadotropin (HCG). Two patients had embryonal carcinomas, two had choriocarcinomas, and two had dysgerminomas. The marker profile for a given tumor in either CSF or serum correlated with the histological diagnosis; that is, embryonal carcinoma produced AFP and HCG, choriocarcinoma produced HCG, and dysgerminoma produced no markers. The marker levels in serum and CSF declined with therapy and rose usually prior to the development of overt clinical symptoms if the patient's tumor recurred. A CSF-to-serum gradient of the marker levels was present in three of four patients, and the serum levels were often normal when the CSF values were elevated. Ventricular marker levels were lower than the lumbar levels in two of two patients. The assay of these biological markers is a sensitive indicator of the success of therapy, and the presence of a CSF-to-serum gradient suggests that the major portion of the neoplasm rests within the central nervous system. A histological diagnosis can be inferred without the necessity of surgery in appropriate clinical contexts.
- - - - - - - - - -
ranking = 2
keywords = dysgerminoma
(Clic here for more details about this article)

6/6. Ovarian mixed germ cell tumor composed of dysgerminoma, endodermal sinus tumor, choriocarcinoma and mature teratoma in a 44-year-old woman: case report and literature review.

    A case of ovarian mixed germ cell tumor in a 44-year-old woman was examined. The tumor was well circumscribed, measured 15 x 11 x 10 cm and appeared solid and partly cystic on the cut surface. light microscopic examinations revealed that the tumor was composed of four different neoplastic germ cell elements, intermingled with each other. They are: (i) choriocarcinoma, immunohistochemically positive for human placental lactogen (hPL) and human chorionic gonadotropin (hCG); (ii) dysgerminoma, positive for placental alkaline phosphatase; (iii) endodermal sinus tumor positive for alpha-fetoprotein (AFP); and (iv) mature teratoma. Among these histological types, dysgerminoma occupied more than 50% of the neoplasm. The patient was diagnosed as a stage la ovarian mixed germ cell tumor and was subsequently treated with chemotherapy. A second-look laparotomy after completion of chemotherapy revealed no residual tumors in the abdomen and the patient is alive and well 15 months after operation. This is the fourth reported case of ovarian mixed germ cell tumor arising in patients over 40 years old.
- - - - - - - - - -
ranking = 6
keywords = dysgerminoma
(Clic here for more details about this article)


Leave a message about 'Choriocarcinoma'


We do not evaluate or guarantee the accuracy of any content in this site. Click here for the full disclaimer.