Cases reported "Chorioretinitis"

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1/3. herpes simplex chorioretinitis in a healthy adult.

    A previously healthy 20-year-old man developed bilateral chorioretinitis that included mild anterior uveitis, vitreous cells, multifocal chorioretinitis, and optic nerve swelling that progressed to severe optic neuropathy in one eye. Chorioretinal biopsy specimens cultured herpes simplex type 1 from separate chorioretinal and vitreous samples. Although the visual acuity of one eye remained at light perception, sight in the second eye was saved when treatment with systemic acyclovir and corticosteroids led to resolution of the inflammation. A recurrence was successfully treated with acyclovir alone and the patient shows no evidence of active disease.
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2/3. Cryptococcal chorioretinitis.

    A 40-year-old man developed obstructive hydrocephalus of uncertain cause followed by bilateral intraocular inflammation, which was initially diagnosed as toxoplasmic retinochoroiditis. When visual acuity in the left eye decreased to no light perception and vision in the right eye was failing, a diagnostic enucleation of the blind left eye was performed. A diagnosis of cryptococcal endophthalmitis was established and the remaining right eye showed improvement after systemic anticryptococcal therapy.
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3/3. toxoplasma gondii retinochoroiditis after liver transplantation.

    A 48-year-old woman with a previous a liver transplant and a cataract extraction developed a necrotizing retinochoroiditis in her right eye. Vitreous and serum cultures failed to yield a causative organism. As the retinochoroiditis progressed, visual acuity worsened to the point of no light perception, and the eye became blind and painful. An enucleation was performed and histologic examination showed toxoplasma gondii necrotizing retinochoroiditis. This is the first histologically documented case of T. gondii retinochoroiditis after liver transplantation. The fulminant clinicopathologic appearance of the retinochoroiditis is similar to that previously reported to occur in acquired immune deficiency syndrome (AIDS) and other forms of immunosuppression, unlike the reactivated congenital retinochoroiditis that occurs in immunocompetent patients.
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