Cases reported "Choroid Neoplasms"

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1/27. Effects of transpupillary thermotherapy on immunological parameters and apoptosis in a case of primary uveal melanoma.

    Transpupillary thermotherapy (TTT) is a new treatment modality for uveal melanoma. We studied whether application of TTT influences the immunogenicity of the tumour cells in vivo or the expression of molecules related to apoptosis. immunohistochemistry using monoclonal antibodies directed against HLA molecules, HMB45, P53, Fas ligand (FasL), Fas, Bcl-2 and tumour-infiltrating cells was applied to sections of an enucleated eye containing a uveal melanoma that received TTT 1 week before enucleation. The innermost part of the tumour which had been exposed directly to the laser treatment showed no staining for hla antigens, nor for Fas or FasL epitopes. The intermediate part of the tumour showed a wet necrosis and HLA expression similar to the expression in the peripheral tumour. A large number of macrophages were observed in the necrotic as well as the intact tumour tissue, especially bordering the wet necrotic area. FasL and Bcl-2 were only expressed in the viable, outer part of the tumour. This immunological evaluation of one case of uveal melanoma treated with TTT revealed that TTT may not only have a direct destructive effect on the primary tumour, but may also influence the immunogenicity of uveal melanoma cells, induce infiltration of macrophages into the tumour, and induce apoptosis. The presence of many macrophages suggests that they play a role in the removal of the TTT-treated tumour tissue by phagocytosis.
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2/27. Choroidal metastasis presented as the initial symptom of the recurrence from ovarian endometrioid adenocarcinoma: A case report.

    Choroidal metastasis from recurrent ovarian cancer is extremely rare. To our knowledge, this report is the first such case of endometrioid adenocarcinoma. A 30-year-old pregnant woman presented to an ophthalmologist in January 1999 because of a rapid visual deterioration. Ophthalmologic evaluation revealed a metastatic choroidal tumor from ovarian cancer which had been diagnosed 10 years ago. After cesarean section, multiple metastases were found including the choroid, scalp, bone, and lung, and she received four courses of single agent carboplatin chemotherapy. She died of disease in July 1999. This case highlights the need to investigate the etiology of visual complaints in patients with a history of ovarian cancer even in the early stage.
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ranking = 0.00072883416692624
keywords = bone
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3/27. Bilateral choroidal metastases as the initial presentation of breast carcinoma.

    A 64 year old female presented with a right eye visual impairment. On examination, the visual acuity was decreased on the right side. Slit lamp examination showed bilateral non-pigmented choroidal lesions. physical examination was unremarkable; bilateral mammogram, however, showed a mass in the left breast, the biopsy from which confirmed the lesion as infiltrative carcinoma. Other tests were normal apart from the isotope bone scan which showed evidence of metastatic disease. She received a short course of radiotherapy to both eyes as well as a 6-month course of chemotherapy. At 6 months follow-up, the choroidal lesions were no longer present and the visual acuity had stabilized. Choroidal metastasis as the initial presentation of breast carcinoma is unusual. Any patient with an ocular tumour should undergo a systemic check-up to rule out an underlying malignancy.
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ranking = 0.00072883416692624
keywords = bone
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4/27. axons in human choroidal melanoma suggest the participation of nerves in the control of these tumors.

    PURPOSE: To furnish morphologic evidence of autonomic nervous system influence on choroidal melanoma. DESIGN: Histopatholgic case report. methods: In the enucleated eye of a 72-year-old woman, portions of a mixed-cell choroidal melanoma were processed for electron microscopy, and ultrathin sections were screened painstakingly under magnifications of x13,000 and x23,000. RESULTS: The connective tissue of the melanoma contained macrophages, blood vessels, and profiles of several nonmyelinated nerve fiber bundles with a maximum of 6 axons. CONCLUSION: The existence of axons in neoplastic tissue indicates nervous input and/or output. This led us to conclude that the reaction of the melanoma is subjected to vegetative influences, yet to an unknown extent.
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keywords = macrophage
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5/27. Orbital metastasis from prostatic carcinoma.

    A rare case of orbital metastasis from carcinoma of the prostate in a 76-year-old man who presented with pain in his left eye, mild proptosis and reduced visual acuity is reported. Cranial CT scanning demonstrated large bone metastases in the left orbit. The patient underwent orbital evisceration. The histopathological studies that were based on the morphological and immunohistochemical findings confirmed the histological diagnosis of orbital metastasis arising from prostatic carcinoma with neuroendocrine features.
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ranking = 0.00072883416692624
keywords = bone
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6/27. Rieger anomaly with bilateral choroidal osteoma: coincidence or association?

    PURPOSE: To report a case of Rieger anomaly associated with bilateral choroidal osteoma. CASE: An 18-year-old woman presented with corectopia, iridocorneal adhesions, and stromal hypoplasia of the iris, and was diagnosed with Rieger anomaly. RESULTS: Fundus examination revealed bilateral yellowish-orange, placoid degenerative fundus lesions with pseudopod-like edges associated with the areas of retinal pigment epithelium atrophy, indicating choroidal osteoma. Fundus fluorescein angiography showed bilateral early patchy and late diffuse hyperfluorescence. B-scan echography revealed placoid lesion at the posterior ocular coats characterized by localized areas of high ultrasound reflectivity with a corresponding retrobulbar orbital shadowing. This indicated a dense calcium foreign body. In addition, computed tomography of the orbit demonstrated bilateral plate-like thickening with calcification of the choroid that was isodense with the normal skeletal bone. CONCLUSIONS: Although Rieger anomaly is classically known as a disease of the anterior segment of the eye, choroidal osteoma may be a posterior segment finding of the disease that has not previously been reported.
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ranking = 0.00072883416692624
keywords = bone
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7/27. Choroidal melanoma with massive lipid exudation in a patient with metastatic hypernephroma.

    A 75-year-old woman with diffuse metastatic hypernephroma had a unilateral total exudative retinal detachment associated with a big choroidal mass. In addition, multiple yellow-white intra- and subretinal deposits were seen around the tumor. These findings and the patient's medical history led us to think of choroidal metastatic hypernephroma with intraocular spread. However, histopathologic examination revealed the presence of epithelioid malignant melanoma of the choroid with numerous retinal and subretinal lipid deposits and lipid-laden macrophages. This picture of massive lipid exudation is rare in untreated choroidal melanomas.
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keywords = macrophage
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8/27. Bilateral uveal metastases from small-cell carcinoma of the lung.

    Metastasis from small-cell carcinoma of the lung (SCCL) has most frequently been found in the lymph nodes, bones, brain, and liver. We have reported a case of metastatic SCCL located in the uveal layer of both eyes (choroidal in one and iridic in the other), an extremely rare occurrence.
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ranking = 0.00072883416692624
keywords = bone
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9/27. Presumed eccrine carcinoma metastatic to the choroid.

    The purpose of this article is to describe a patient with presumed choroidal metastasis from an eccrine adenocarcinoma of the scalp. A 45-year-old Caucasian woman presented with decreased visual acuity. Ophthalmologic examination was unremarkable. Her past medical history was significant for eccrine carcinoma of the scalp. The patient developed bilateral cervical lymph node metastases, and received chemotherapy and radiotherapy. She had recurrence of the scalp lesion and developed bone metastasis. The patient was again referred to an ophthalmologist owing to reduced visual acuity. Multiple choroidal metastases were detected in right eye, and one metastatic lesion in left eye. The patient passed away 2 months after choroidal metastases. This is the first report of choroidal metastases from an eccrine carcinoma. This is a rare aggressive neoplasm with poor outcome in most cases of metastatic disease, and in this case report, uveal metastasis was indicative of poor prognosis.
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ranking = 0.00072883416692624
keywords = bone
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10/27. magnetic resonance imaging in choroidal osteoma.

    High resolution magnetic resonance imaging (MRI) with surface coil and contrast material was used to demonstrate the presence of bone in choroidal osteoma. Contrary to initial impressions, choroidal osteoma does not show typical negative image of the bone in MRI scans. The ossifying tumor of the choroid appears as a bright (hyperintense) signal on T1-weighted images and as an area of relative low intensity on T2-weighted images. On contrast T1-weighted scans, the tumor showed gadolinium-DPTA (Gd-DPTA) enhancement. These MRI findings are discussed in relation with histopathologic features of choroidal osteoma and the presence of fat marrow in the intertrabecular spaces of the bone at the level of the choroid.
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ranking = 0.0021865025007787
keywords = bone
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