Cases reported "Choroid Neoplasms"

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1/394. Multifocal choroidal malignant melanoma: at least 3 melanomas in one eye.

    OBJECTIVES: To describe a case of an enucleated eye harboring multiple choroidal malignant melanomas. methods: Clinical, ultrasonographic, and histopathological evaluations. RESULTS: Meticulous sectioning of the globe did not disclose any structural continuity between the 3 choroidal melanomas. Fourth and fifth masses were connected to one of the tumors by fibrous tissue and therefore were not considered as additional distinct lesions. CONCLUSION: Although very rare, a single eye can harbor multiple distinct choroidal melanomas.
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ranking = 1
keywords = melanoma, malignant melanoma
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2/394. Early-onset scleral necrosis after iodine I 125 plaque radiotherapy for ciliochoroidal melanoma.

    A 62-year-old man with a large ciliochoroidal melanoma developed early-onset scleral necrosis with tumor extrusion within 1 month of epibulbar iodine I 125 plaque radiotherapy. The eye was enucleated. Pathologic study revealed nonmicrobial scleral necrosis with extrusion of histologically intact and necrotic uveal melanoma cells. The patient has been followed up for 15 months without clinical recurrence. We discuss possible mechanisms to explain the early development of scleral necrosis after plaque therapy in this patient.
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ranking = 0.47033108370278
keywords = melanoma
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3/394. Radioactive phosphorus uptake testing of choroidal lesions. A report of two false-negative tests.

    Two false-negative results from 32P testing for histologically verified malignant melanomas of the choroid are reported. In the first case, a haemorrhagic choroidal detachment caused an increase in probe; additionally, the tumour was necrotic. Both factors are likely to have contributed to the false-negative result. A satisfactory explanation for the false-negative result in the second case was not determined, although it may have accurately reflected a period of minimal tumour activity, inasmuch as repeat 32P testing was strongly positive eight months later, when unequivocal evidence of tumour growth was present. An alternative explanation is that the orally administered 32P was incompletely absorbed. Since 32P testing is frequently accompanied by significant manipulation both in the manoeuvre associated with tumour localization and in that associated with the actual radioactive counting, it would seem desirable to perform indicated enucleation immediately after completion of the 32P testing. While the properly performed 32P test remains a valuable diagnostic test for helping to establish the presence or absence of malignancies of the posterior globe, it is important to guard against the tendency to underestimate careful clinical evaluation.
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ranking = 0.10593378325944
keywords = melanoma, malignant melanoma
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4/394. Iatrogenic breaks in Buuch's membrane in choroidal melanoma.

    Three patients with choroidal melanoma have been observed to develop subretinal hemorrhages associated with their ocular examinations. One hemorrhage appears to have been caused by transillumination, while two others have occurred during radioactive phosphorus testing. Histopathology confirms defects in Bruch's membrane through which blood or tumor cells have entered the subretinal space.
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ranking = 0.39194256975231
keywords = melanoma
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5/394. Clinical experience with presumed hemangioma of the choroid: radioactive phosphorus uptake studies as an aid in differential diagnosis.

    A total of 27 cases of choroidal hemangioma was evaluated with radioactive phosphorus uptake studies. In each case the diagnosis of malignant melanoma was initially entertained, but the 32P test was unequivocally negative in every instance. follow-up studies in every case have supported the clinical diagnosis. In 22 patients, the lesion was treated with photocoagulation, and in every treated case the serous macular detachment disappeared. The importance of early and correct clinical diagnosis is stressed, since these are salvageable and potentially useful seeing eyes.
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ranking = 0.10593378325944
keywords = melanoma, malignant melanoma
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6/394. Tumor growth of a choroidal malignant melanoma and aqueous flare. Report of a case.

    We report the use of the laser flare-cell meter (LFCM) in monitoring blood-ocular barrier breakdown induced by a choroidal malignant melanoma in an 88-year-old white male, who refused enucleation or radiation treatment. During a follow-up of 16 months, aqueous flare values measured with the LFCM increased from 12.8 to 26.5 photon counts/ms with continuous tumor growth from a height of 7.9 to 18 mm. Our finding of increasing flare values with tumor growth appears to confirm the observation that aqueous flare is influenced by the size of uveal malignant melanomas. Quantification of aqueous flare with the LFCM may be helpful in the follow-up of eyes with intraocular tumors.
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ranking = 0.63560269955667
keywords = melanoma, malignant melanoma
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7/394. Malignant melanoma of the choroid in neurofibromatosis.

    A 60-year-old white woman with generalized neurofibromatosis and multiple melanocytic hamartomas of the iris developed an unusual choroidal mass, with secondary sensory retinal separation in the left eye. Ophthalmoscopically the tumor had a peculiar donut configuration that was caused by a large focus of central necrosis within a spindle B melanoma.
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ranking = 0.39194256975231
keywords = melanoma
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8/394. Primary laser photocoagulation of "small" choroidal melanomas.

    PURPOSE: To evaluate primary laser photocoagulation of "small" posterior choroidal melanomas in eyes with good vision. METHOD: This study includes a case series comprising six patients treated with standard laser techniques for melanoma, which had a mean thickness of 3.1 mm (range 2.9-3.9 mm), largest basal diameter of 8.6 mm (mean, range 7.0-10.0 mm), and located 0.5-2 disk diameters from the fovea or 0.3-3 disk diameters from the optic nerve head. RESULTS: No metastatic death was observed in the follow-up period (range 3 1/2-7 1/2 years). Two local recurrences appeared, both were treated with plaques, one eye was later enucleated. Two additional cases were also treated with plaques. Only two of the irradiated eyes retained reading vision. CONCLUSION: Primary photocoagulation of "small" posterior choroidal melanomas with argon laser is not recommended.
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ranking = 0.54871959765324
keywords = melanoma
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9/394. Multifocal intraocular malignant melanoma: report of two cases and review of the literature.

    PURPOSE: To describe two eyes from two patients with multifocal primary intraocular melanoma. DESIGN: Two case reports. methods: The history and histologic findings in the enucleated eyes of two patients with multifocal intraocular melanoma are described in comparison to previously reported cases. MAIN OUTCOME MEASURES: Pathologic examination of enucleated eyes. RESULTS: One of the two eyes contained mixed cell type melanomas, and one eye contained spindle cell type melanomas. Examination of serial sections showed no continuity between the intraocular melanomas. There were no associated ocular or systemic conditions with the multifocal intraocular melanomas. CONCLUSIONS: Multifocal primary intraocular melanoma is rare. There is no known predisposing factor to this condition.
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ranking = 0.97245473069102
keywords = melanoma, malignant melanoma
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10/394. Extraocular extension of unrecognized choroidal melanoma simulating a primary optic nerve tumor: report of two cases.

    BACKGROUND: Orbital extraocular extension of choroidal melanoma is well known and is usually detected in eyes with medium and large tumors, but it is very rare with small melanomas. It is particularly unusual for choroidal melanomas of any size to invade the optic nerve or its meninges. DESIGN: Two case reports. PARTICIPANTS: Two patients with small, relatively inconspicuous juxtapapillary pigmented choroidal lesions were referred with the diagnosis of primary optic nerve tumor. Both demonstrated a large nodular tumor in the meninges of the optic nerve, immediately posterior to the globe. methods: Retrospective review of clinical records and histopathology. RESULTS: In both cases, orbital magnetic resonance imaging confirmed the presence of a hyperintense enhancing nodular mass near the anterior portion of the optic nerve, prompting optic nerve biopsy in one case. Subsequent fundus examination disclosed a small juxtapapillary pigmented choroidal lesion measuring 1.0 mm or less in thickness. These observations suggested that the optic nerve tumor might be nodular extraocular extension of a small choroidal melanoma. Modified enucleation was performed in both cases, and histopathologic examination revealed a nodule of malignant melanoma within the meninges that compressed the optic nerve and extended extraocularly from a small, relatively inapparent juxtapapillary choroidal melanoma. In both cases, the extraocular component was large and symptomatic, whereas the intraocular component was inconspicuous. CONCLUSIONS: Small juxtapapillary choroidal melanomas can exhibit prominent extension into the orbit. All patients with orbital tumors should have careful ophthalmoscopy.
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ranking = 0.88981892276407
keywords = melanoma, malignant melanoma
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