Cases reported "Cocarcinogenesis"

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1/5. Squamous cutaneous epithelial cell carcinoma in two CML patients with progressive disease under imatinib treatment.

    Imatinib (glivec), formerly known as STI571) effectively blocks the ATP-binding site of the bcr/abl fusion protein thereby inactivating selectively the tyrosine kinase activity of bcr/abl. Therefore, it is a promising drug in philadelphia chromosome positive chronic myeloid leukemia showing high hematologic and cytogenetic response rates combined with a mild toxicity profile. Here we report two cases of squamous cell carcinoma of the skin, which appeared in the photo-exposed areas in two elderly patients treated for advanced chronic myeloid leukemia with imatinib. The role of chemotherapy, chronic sun exposure and of possible additional risk factors such as human papillomavirus infection is discussed.
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ranking = 1
keywords = exposure
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2/5. Exposure to chemicals, physical agents, and biologic agents in mycosis fungoides and the sezary syndrome.

    The history of occupational, environmental, and/or iatrogenic exposure to potential carcinogenic agents was obtained at the time of onset of skin disease in 43 of 44 patients with cutaneous T-cell lymphoma (mycosis fungoides and the sezary syndrome) entering a National Cancer Institute therapeutic trial. A history of multiple exposures to these agents was common, the two most frequent being chemicals (91% of patients) and drugs (86%). Mean duration of expsosure was 13 years for chemicals and 18 years for drugs. The most common chemicals were air pollutants (39%), pesticides (36%), solvents and vapors (30%), and detergents and disinfectants (14%). Increased severity of disease was seen with increaed duration of chemical exposure in stage V cutaneous T-cell lymphomas only. The most frequent drugs besides tobacco (86%) were analgesics (20%), tranquilizers (18%), and thiazides (14%). Second cancers occurred in four patients, including two renal cell carcinomas, and a family history of cancer was present in 11. Fourteen of 22 patients questioned had recurrent herpes simplex. patients with chronic skin disease who have long-term exposure to combinations of chemicals, physical agents, and biologic agents, are heavy smokers, or have recurrent herpes simplex appear to be prime candidates for developing mycosis fungoides or the sezary syndrome.
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ranking = 4
keywords = exposure
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3/5. Osteogenic sarcoma following treatment with megavoltage radiation and chemotherapy for bone tumors in children.

    While osteogenic sarcoma has been well-recognized as a late complication of exposure to high doses of ionizing radiation in the orthovoltage energy range, it has been less frequently reported in patients treated with megavoltage radiation. This potential complication should, however, not be dismissed as an occurrence to be seen only after high-dose orthovoltage radiation. We have recently seen two children who developed osteogenic sarcoma following treatment with megavoltage radiation and combination chemotherapy for primary bone tumors. The implications in regard to aggressive multimodality treatment for pediatric malignancies are discussed.
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ranking = 1
keywords = exposure
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4/5. ontario gold miners with lung cancer. occupational exposure assessment in establishing work-relatedness.

    Because of inherent errors in exposure data as well as a requirement in the workers' compensation Act of ontario that all claims must be considered on the merits and justice of the individual case, the criteria for assessing work-relatedness of ontario gold miners who had primary lung cancer could not be based upon any strict occupational exposure criteria. However, a relationship between exposure to silica, arsenic, and radon progeny was derived from results of the epidemiologic studies. A retrospective occupational exposure assessment of silica dust, arsenic, and radon decay products was made in individual cases presented in this paper. The assessment results of 11 gold miners presented in this paper illustrate that the exposure parameters could provide persuasive evidence when the data were consistent with the key epidemiologic findings, eg, the miner's age at first exposure, length of dusty exposure, and latency.
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ranking = 809.22018703901
keywords = occupational exposure, exposure
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5/5. Aggressive squamous cell carcinomas developing in patients receiving long-term azathioprine.

    We report three patients who developed unusually aggressive squamous cell carcinomas after receiving long-term azathioprine treatment for dermatological disorders. Two patients gave a history suggestive of moderate to excessive sun exposure, and the third suffered from chronic actinic dermatitis. Hence, ultraviolet light damage may have been a significant cofactor in the development of these malignancies. Careful follow-up is necessary in patients who are taking azathioprine long term, and who have previously been excessively exposed to ultraviolet light (UVL), or in whom future exposure is likely to be excessive. We suggest that strict sun avoidance measures are followed by patients on long-term azathioprine, or that alternatives to azathioprine therapy are considered, especially in individuals inherently at risk of UVL damage, and in those already showing clinical signs of such damage.
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ranking = 2
keywords = exposure
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