1/24. Collagen vascular diseases and radiation therapy: a critical review.PURPOSE: Although many oncologists have the impression that patients with collagen vascular disease tolerate radiotherapy less well than other patients, until now this was never described in a review article. methods AND RESULTS: The principal objective was to determine whether patients with collagen vascular diseases have a greater risk of severe radiation therapy complications, than those without a collagen vascular disease. However, most of the publications found on this topic are short anecdotal case reports of patients with increased toxicity after radiation. Consequently, the true incidence of these side effects is unknown. CONCLUSIONS: Unless further studies on this subject are reported, each radiation oncologist should be cautious in treating these patients.- - - - - - - - - - ranking = 1keywords = vascular disease (Clic here for more details about this article) |
2/24. Treatment of pruritis of reactive perforating collagenosis using transcutaneous electrical nerve stimulation.Reactive perforating collagenosis is a form of perforating dermatosis due to transepithelial elimination of collagen and characterized by itchy papulonodular eruptions frequently seen in patients with diabetes mellitus and end stage renal failure. pruritus is often severe and treatment is difficult. Two adult Chinese diabetic patients with acquired reactive perforating collagenosis unresponsive to topical therapies and oral antihistamines, were treated with transcutaneous electrical nerve stimulation. There was a significant reduction of itch followed by gradual resolution of the skin lesions.- - - - - - - - - - ranking = 0.0038524647604853keywords = diabetic (Clic here for more details about this article) |
3/24. Cutaneous aspects of down syndrome.down syndrome is associated with an increased incidence of cutaneous manifestations such as atopic dermatitis, alopecia areata, elastosis perforans serpiginosa, syringomas, and skin infections. We describe 3 patients with down syndrome: an 8-year-old boy with alopecia areata, a 17-year-old boy with crusted scabies, and a 39-year-old woman with a cutaneous collagen vascular disease-like disorder. We also review cutaneous signs of this syndrome.- - - - - - - - - - ranking = 0.14285714285714keywords = vascular disease (Clic here for more details about this article) |
4/24. Acquired reactive perforating collagenosis in a diabetic patient with pulmonary aspergillosis.Reactive perforating collagenosis (RPC) is a rare disorder characterized by transepidermal elimination of altered collagen. The acquired form of RPC manifests in adult life and is accompanied by general pruritus and scratching. diabetes mellitus and end-stage renal disease are frequently associated with RPC. We describe a case of RPC developing after pulmonary aspergillosis in a 54-year-old man with long-standing insulin-dependent diabetes and discuss possible etiologic relations.- - - - - - - - - - ranking = 0.015409859041941keywords = diabetic (Clic here for more details about this article) |
5/24. Treatment of perforating collagenosis of diabetes and renal failure with allopurinol.We present a case of widespread reactive perforating collagenosis in a 63-year-old woman undergoing haemodialysis after diabetic nephropathy, who was treated successfully with allopurinol. The patient responded well and rapidly to a dose of 100 mg allopurinol daily. It is suggested that more patients with reactive perforating collagenosis may benefit from allopurinol therapy.- - - - - - - - - - ranking = 0.0038524647604853keywords = diabetic (Clic here for more details about this article) |
6/24. A case of idiopathic nodular glomerulosclerosis mimicking diabetic glomerulosclerosis (Kimmelstiel-Wilson type).A case of idiopathic nodular glomerulosclerosis mimicking diabetic Kimmelstiel-Wilson glomerulopathy is reported. The patient was a 45-year-old man suffering from nephrotic syndrome. light and electron microscopy revealed diffuse and nodular glomerulosclerosis indistinguishable from diabetic nodular glomerulosclerosis. diabetes mellitus, however, had been excluded both by extensive clinical and by laboratory investigation. The differential diagnosis also included amyloidotic and non-amyloidotic fibrillary glomerulopathy, light chain glomerulopathy, collagen type iii disease, immunotactoid glomerulopathy, and the sclerosing variant of membranoproliferative glomerulonephritis. immunohistochemistry and ultrastructural investigations, however, excluded these entities, and the diagnosis of idiopathic nodular glomerulosclerosis was made. This variant has to be included in the differential diagnosis of nodular glomerulopathy associated with nephrotic syndrome.- - - - - - - - - - ranking = 0.023114788562912keywords = diabetic (Clic here for more details about this article) |
7/24. Acquired reactive perforating collagenosis in a nondiabetic hemodialysis patient: successful treatment with allopurinol.The authors present a case of acquired reactive perforating collagenosis developed in a nondiabetic hemodialysis patient, who was treated successfully with allopurinol. Treatment of acquired reactive perforating collagenosis is difficult and often ineffective. The patient had been unresponsive to conventional treatments, but the pruritus was controlled, and skin lesions subsequently resolved after the treatment with allopurinol. Possible mechanisms of allopurinol treatment for acquired reactive perforating collagenosis are discussed.- - - - - - - - - - ranking = 0.019262323802427keywords = diabetic (Clic here for more details about this article) |
8/24. tuberculosis or systemic lupus erythematosus? A diagnostic and therapeutic dilemma.The diagnosis of patients with fever of unknown origin (FUO) is often problematic because the range of possible differential diagnoses is broad. We report on a case in which a patient presented with FUO and was subsequently found to have both a collagen vascular disease and an intercurrent infection. Treatment for the collagen vascular disease with corticosteroids exacerbated the intercurrent infection. The problems in the diagnosis and management of such cases are discussed.- - - - - - - - - - ranking = 0.28571428571429keywords = vascular disease (Clic here for more details about this article) |
9/24. Reactive perforating collagenosis associated with scabies in a diabetic.Reactive perforating collagenosis (RPC) in adults commonly manifests in patients with diabetes mellitus. pruritus and consequent induced scratching have been identified as the bases for the evolution of this skin disease. We present the unusual case of a 55-year-old female diabetic with characteristic umbilicated skin lesions and a long history of scabies. histology from a crusty nodule revealed transepidermal elimination of collagen. Following antiscabietic treatment, two courses of oral doxycycline demonstrated beneficial effects in controlling the perforating skin disorder.- - - - - - - - - - ranking = 0.019262323802427keywords = diabetic (Clic here for more details about this article) |
10/24. Intramembranous fine deposit disease associated with collagen disorders: a new morphological entity?A distinct, hitherto unknown renal histopathological appearance, consisting of diffuse thickening of the glomerular basement membrane (GBM) with fine intramembranous electron-dense deposits, was observed in the renal biopsies from three patients with collagen diseases. In each case, proteinuria was mild with normal urinary sediment. On light microscopy there were no particular abnormalities but a mild thickening of the glomerular capillary wall. Immunofluorescence studies revealed faint linear or extremely fine granular IgG deposition along the capillary wall. On electron microscopy, the GBM was diffusely thickened with fine intramembranous electron-dense deposits without spike formation. No other deposits were seen in the glomerulus. These histological features resembled those of membranous glomerulonephritis (MGN), although the possibility of the early change of MGN is excluded by specific findings in these cases. Other GBM-thickening diseases such as diabetic glomerulosclerosis were ruled out clinically and histologically. Our cases have a singular renal histopathology which differs from any of the previously established classifications of glomerular lesions. It may be a specific change associated with some type of collagen disease.- - - - - - - - - - ranking = 0.0038524647604853keywords = diabetic (Clic here for more details about this article) |
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