1/10. Hamartomas of the iris and ciliary epithelium in tuberous sclerosis complex.Astrocytic hamartomas of the retina are the principal ocular manifestation of tuberous sclerosis complex. iris abnormalities are rare in tuberous sclerosis complex and include focal areas of stromal depigmentation and atypical colobomata. We describe 2 patients who were found on histopathological examination to have lesions consistent with hamartomas of the iris pigment epithelium and ciliary body epithelium. iris abnormalities, including pupillary irregularities, were noted on clinical examination prior to the development of iris neovascularization in both patients. These observations suggest that iris abnormalities, including atypical colobomas, may be caused by hamartomas of the iris pigment epithelium and ciliary epithelium in some patients with tuberous sclerosis complex. To our knowledge, hamartomas of tissues derived from the anterior part of the neuroectodermal optic cup have not been reported in cases of tuberous sclerosis complex.- - - - - - - - - - ranking = 1keywords = neovascularization (Clic here for more details about this article) |
2/10. iris neovascularization in children as a manifestation of underlying medulloepithelioma.PURPOSE: To report the occurrence of unilateral iris neovascularization in children secondary to medulloepithelioma. methods: Presenting features and the clinical course of patients confirmed to have medulloepithelioma were reviewed. RESULTS: Seven patients with medulloepithelioma had iris neovascularization during the clinical course. Associated cataract and lens coloboma occurred in two and three cases, respectively. In six (86%) cases, no apparent cause for iris neovascularization could be detected at presentation. Two cases had tube shunts for management of neovascular glaucoma before medulloepithelioma was recognized. All cases eventually required enucleation. CONCLUSION: Presence of iris neovascularization is an early manifestation of medulloepithelioma. Children with iris neovascularization of unknown cause should be evaluated to exclude underlying medulloepithelioma.- - - - - - - - - - ranking = 9keywords = neovascularization (Clic here for more details about this article) |
3/10. Subretinal neovascularization associated with retinochoroidal coloboma.PURPOSE: To report a case of subretinal neovascularization associated with retinochoroidal coloboma. methods AND RESULTS: A 44-year-old female presented with metamorphopsia in her right eye for 4 weeks. Funduscopic examination revealed bilateral inferior retinochoroidal coloboma. fluorescein angiography disclosed foci of subretinal neovascularization at the margin between the colobomatous defect and the normal-appearing retina. Five month later, multiple small areas of subretinal hemorrhages were noted. The hemorrhage was gradually absorbed. Six years after initial presentation, subretinal hemorrhage did not recur and her right VA was 0.2. CONCLUSIONS: Ophthalmologists should be aware of this rare but important complication of retinochoroidal coloboma.- - - - - - - - - - ranking = 6keywords = neovascularization (Clic here for more details about this article) |
4/10. Retinochoroidal coloboma and subretinal neovascularization.Subretinal neovascularization associated with retinochoroidal coloboma is rare. To the authors' knowledge, only three cases have been reported. We report a new case of isolated subretinal neovascularization and coloboma in a 26-year-old woman without other causes of choroidal neovascularization. Only the disruption of the normal retinal anatomy could explain the development of this subretinal neovascularization.- - - - - - - - - - ranking = 8keywords = neovascularization (Clic here for more details about this article) |
5/10. Retinochoroidal coloboma: varieties of clinical presentations.Several presentation and associated clinical problems can be seen with retinochoroidal colobomas. We review five cases of retinochoroidal coloboma with no specific clinical problems and present five cases with clinical visual impairment. The five symptomatic cases include: one with extensive bilateral involvement; one with associated rhegmatogenous detachment and peripheral tears; one with retinal detachment and apparent holes in the intercalary membrane; one with subretinal neovascularization; and a case with diabetic retinopathy, optic nerve coloboma, and peripheral retinochoroidal coloboma in one eye and a total coloboma in the other eye.- - - - - - - - - - ranking = 1keywords = neovascularization (Clic here for more details about this article) |
6/10. Retinochoroidal coloboma associated with subretinal neovascularization.Reported herein are the cases of two patients who developed subretinal neovascularization at the margin of a retinochoroidal coloboma. Possible explanations for the occurrence of this previously unemphasized association are addressed.- - - - - - - - - - ranking = 5keywords = neovascularization (Clic here for more details about this article) |
7/10. Laser treatment of a subretinal neovascular membrane associated with retinochoroidal coloboma.Subretinal neovascularization associated with retinochoroidal coloboma is a rare finding. Only two other cases have been reported in the literature, neither of which were treated with photocoagulation. Here, the author reports a case of subretinal neovascular net associated with a retinochoroidal coloboma, which was treated with laser photocoagulation. The patient's vision improved from 20/200 to 20/30-1 following two argon green laser treatments, with a 33-month follow-up since the initial treatment.- - - - - - - - - - ranking = 1keywords = neovascularization (Clic here for more details about this article) |
8/10. Subretinal neovascularization associated with retinochoroidal colobomas.The development of subretinal neovascularization as a complication of retinochoroidal coloboma has been reported in only three cases, in only one of which was the patient treated with laser photocoagulation. We report an additional case of subretinal neovascularization associated with retinochoroidal coloboma in a 57-year-old man that was treated with laser photocoagulation. The patient's visual acuity has remained stable at 20/50.- - - - - - - - - - ranking = 6keywords = neovascularization (Clic here for more details about this article) |
9/10. Posterior segment neovascularization associated with optic nerve aplasia.PURPOSE: To report the presence of posterior segment neovascularization in eyes with optic nerve aplasia. methods: Three eyes in two patients with clinical optic nerve aplasia were studied. RESULTS: Examination disclosed posterior segment neovascularization in one eye and progressive posterior segment neovascularization in two eyes. CONCLUSIONS: Posterior segment neovascularization may occur in association with optic nerve aplasia. Retinal ischemia or retinochoroidal anatomic disorganization, or both, may provide the stimulus for neovascularization in such eyes.- - - - - - - - - - ranking = 9keywords = neovascularization (Clic here for more details about this article) |
10/10. Corneal coloboma, aphakia and retinal neovascularization with anterior segment dysgenesis (Peters' anomaly).An infant with bilateral Peters' Anomaly, with corneal opacification in the right eye and an opacification with an axial defect in the left also had an associated hydrocephalus and cardiac anomalies that proved fatal; histopathology of the right eye showed retinal neovascularization in addition to findings consistent with a diagnosis of Peters' Anomaly; in the left eye, pathologic findings were suggestive of a corneal coloboma associated with aphakia.- - - - - - - - - - ranking = 5keywords = neovascularization (Clic here for more details about this article) |
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