1/6. corneal opacity and congenital glaucoma associated with massive heparan sulfaturia: report of one case.A four month-old male infant was noted to have had severe corneal opacity since birth. Buphthalmos, increased intraocular pressure and corneal opacity with neovascularization were noted during physical examination. There was neither dysmorphic face nor hirsutism and the liver and spleen were impalpable. In addition, hypotonia, poor head control, and absence of Moro and grasping reflexes were also noted. There was no evidence of congenital infection by TORCH study. Tests of both urine and plasma amino acids were within normal limits. However, excessive urinary excretion of heparan sulfate was detected by thin-layer chromatography. corneal transplantation was performed at 6 months old. Histopathological examination of the corneal button showed homogeneous thickening of Bowmen's membrane and intracytoplasmic pinkish substances in corneal stroma. The alcian blue stain was positive, which was consistent with mucopolysaccharidosis of cornea. The manifestation of this case may be a clinical variant of Sanfilippo's syndrome (Mucopolysaccharidosis type III).- - - - - - - - - - ranking = 1keywords = neovascularization (Clic here for more details about this article) |
2/6. Bilateral corneal neovascularization and opacification associated with unmonitored contact lens wear.PURPOSE: To report a case of severe bilateral deep stromal neovascularization and opacification associated with unmonitored contact lens wear. DESIGN: Observational case report. methods: A 46-year-old woman who had been using hydrogel contact lenses bought on the internet without a prescription for 5 years was found to have dense, bilateral corneal opacities with deep stromal neovascularization. RESULTS: The patient's contact lenses were found to be tight-fitting. Medical history and serological studies were negative for infectious or rheumatologic causes of interstitial keratitis. CONCLUSIONS: The deep stromal neovascularization and the associated corneal opacification are most likely related to the unmonitored contact lens use and the lack of routine eye examinations. We believe it is critical that all contact lens wearers receive professional eye care on a regular basis regardless of where they obtain their contact lens supplies.- - - - - - - - - - ranking = 7keywords = neovascularization (Clic here for more details about this article) |
3/6. Q-switched Nd:YAG laser treatment for corneal neovascularization.Q-switched Nd:YAG laser treatment to occlude newly formed corneal vessels was performed in patients with herpetic keratitis to reduce corneal opacity and the risk of graft rejection. Nine neovascularized corneas of 9 patients were treated. In 8 of the 9 patients, corneal neovascularization was markedly reduced with a resulting decrease in corneal opacity. Penetrating keratoplasty was performed in 3 patients after the treatment. Two patients in whom YAG laser treatment was effective had uneventful postoperative courses for 13 and 17 months, respectively. In one patient with ineffective YAG laser treatment, rejection occurred 3 months after keratoplasty, and systemic steroid and ciclosporin therapy was needed. Ultrastructural examination of the corneal button removed during keratoplasty from a patient with successful laser treatment showed destruction of vascular endothelial cells and occlusion of the vascular lumen.- - - - - - - - - - ranking = 5keywords = neovascularization (Clic here for more details about this article) |
4/6. Penetrating keratoplasty for severe complications of radial keratotomy.Severe sight-threatening complications were seen in five eyes of three patients following improperly performed radial keratotomy. All patients exhibited neovascularization of the incision sites, severe stromal scarring or ulceration involving the visual axis, loss of the anterior chamber, and iridocorneal adhesions. These complications necessitated multiple and complex surgical interventions, including penetrating keratoplasty and anterior segment reconstruction. Final visual acuity was decreased to light perception in four eyes while one eye achieved 6/60 vision following repeated penetrating keratoplasty. The success and safety of radial keratotomy rely on careful case selection, appropriate instrumentation, specialized training, and the ability to perform complex secondary procedures to correct surgical complications.- - - - - - - - - - ranking = 1keywords = neovascularization (Clic here for more details about this article) |
5/6. Bilateral keratitis in lyme disease.lyme disease, caused by the spirochete borrelia burgdorferi, has ophthalmic manifestations. The authors describe two cases of Lyme keratitis characterized by multiple focal, nebular opacities at varying levels of the stroma which may progress to edema, neovascularization, and scarring. Close observation, in addition to systemic antibiotic therapy, may be sufficient if the visual axis is not involved, and the patient is asymptomatic.- - - - - - - - - - ranking = 1keywords = neovascularization (Clic here for more details about this article) |
6/6. Corneal coloboma, aphakia and retinal neovascularization with anterior segment dysgenesis (Peters' anomaly).An infant with bilateral Peters' Anomaly, with corneal opacification in the right eye and an opacification with an axial defect in the left also had an associated hydrocephalus and cardiac anomalies that proved fatal; histopathology of the right eye showed retinal neovascularization in addition to findings consistent with a diagnosis of Peters' Anomaly; in the left eye, pathologic findings were suggestive of a corneal coloboma associated with aphakia.- - - - - - - - - - ranking = 5keywords = neovascularization (Clic here for more details about this article) |