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1/7. Human infections with actinomyces pyogenes (corynebacterium pyogenes).

    actinomyces pyogenes (corynebacterium pyogenes), a well-known pathogen in many animals, was isolated from 11 Danish patients since 1968. Bacteriologic characteristics and clinical pictures of the patients are described. Ability to hydrolyze gelatine, to produce beta-glucuronidase, to reach with antisera against group-G streptococci, and to produce acid from xylose differentiates A. pyogenes from arcanobacterium haemolyticum, with which it has at times been confused. actinomyces pyogenes is an established, but often misrecognized, human pathogen that should be better known to clinical microbiologists.
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2/7. Successful treatment of Corynebacterium striatum endocarditis with daptomycin plus rifampin.

    OBJECTIVE: To report a case of Corynebacterium striatum endocarditis that was treated successfully with daptomycin plus rifampin following an unsuccessful attempt at vancomycin desensitization and failure of linezolid therapy. CASE SUMMARY: A 46-year-old woman with hemodialysis-dependent chronic renal failure was admitted for a graft-related infection. She presented with C. striatum endocarditis that was treated with daptomycin plus rifampin due to a history of allergies to vancomycin and beta-lactam antibiotics and failure of linezolid therapy. The patient received daptomycin and rifampin for a total of 6 weeks. Three months after completion of treatment, no recurrence of endocarditis was evident. DISCUSSION: daptomycin is a lipopeptide antibiotic, with rapid bactericidal activity. It has demonstrated efficacy in animal models of staphylococcal, streptococcal, and enterococcal endocarditis. case reports of its activity in methicillin-resistant staphylococcus aureus endocarditis have also been documented. CONCLUSIONS: daptomycin, which has shown in vitro activity against C. striatum, may be a viable treatment option for patients with C. striatum endocarditis who are either allergic or refractory to traditional antibiotics.
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3/7. Corynebacterium equi peritonitis in a patient receiving peritoneal dialysis.

    Our patient represents the first reported case of peritonitis due to C equi. He had no known exposure to farm or domestic animals, and no evidence of underlying systemic immunodeficiency. After relapse, the patient was successfully treated with vancomycin, and catheter removal was not necessary. We suggest that C equi be added to the growing list of organisms not typically thought to be human pathogens that can cause peritonitis in patients receiving CAPD and recommend intraperitoneal vancomycin as primary therapy. Catheter removal may be necessary to clear the infection. Identification of the organism is important, as it may not respond to treatment with antibiotics such as cephalosporins or penicillins, which are commonly used to treat peritonitis.
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4/7. lung abscess due to Corynebacterium equi in a renal transplant recipient.

    A case of Corynebacterium equi infection in a renal transplant recipient is reported. This not uncommon pathogen of farm animals caused a lung abscess in a graft recipient who had received continuous immunosuppression with azathioprine and prednisone for seven years. Antibiotic therapy yielded radiological improvement, although the patient died from other causes. C. equi joins a growing list of rare opportunistic organisms which may cause disease in subjects who have received transplants.
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5/7. Opportunistic lung infection caused by rhodococcus (Corynebacterium) equi.

    rhodococcus (formerly Corynebacterium) equi, a common animal pathogen, can cause a slowly evolving pneumonia in humans, particularly immunocompromised people. The authors describe two patients; one with acquired immunodeficiency syndrome. On chest radiographs, R. equi produces chronic, localized pulmonary opacities that can cavitate. The main differential diagnoses are tuberculosis and fungal infection.
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6/7. Suppurative granulomatous lymphadenitis caused by corynebacterium ovis (pseudotuberculosis).

    A 30-year-old previously healthy man developed cervical adenopathy associated with mild constitutional symptoms. Corynebacterium ovis was isolated in pure culture from lymph node tissue on two separate occasions, and small gram positive organisms were identified in both lymph nodes with tissue gram stain. Histopathologically, the nodes displayed suppurative and necrotizing granulomas. Of eight previously reported cases of C. ovis lymphadenitis in man, all but one have involved inhabitants of rural australia, most of whom had contact with sheep, an animal reservoir of C. ovis. Necrotizing granulomas were usually observed. The patient described was an American urban dweller with a history of raw milk ingestion. We believe this to be the first reported case of C. ovis lymphadenitis from the united states. C. ovis infection should be considered n the differential diagnosis of localized lymphadenitis with necrotizing and/or suppurative granulomas. In evaluation of granulomatous lymphadenitis tissue gram stain should be performed and culture of a diphtheroid organism not readily dismissed.
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7/7. corynebacterium pseudotuberculosis is a cause of human necrotising granulomatous lymphadenitis.

    corynebacterium pseudotuberculosis is a well recognised pathogen of farm animals, particularly sheep and goats. Human infection is a rare occurrence. This report describes suppurative lymphadenitis occurring in an adolescent boy who had contact with farm animals. The histological differential diagnosis of suppurative granulomatous lymphadenitis is discussed, and the importance of lymph node culture is stressed.
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