Cases reported "Cryptococcosis"

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1/6. Muscular-skeletal cryptococcosis in a patient with idiopathic CD4 lymphopenia.

    A healthy 27-year-old woman presented, four months after childbirth, ingravescent pain and claudication of the left lower limb. magnetic resonance imaging of the lumbosacral and iliac regions showed widespread muscular-skeletal lesions. The patient underwent surgery; cryptococcus neoformans was isolated from surgical samples. Liposomal amphotericin b, fluconazole and itraconazole were administered. Laboratory findings showed lymphocytopenia, with reduction of CD4 lymphocytes (23 cells per cubic millimeter) in the absence of hiv infection and any other defined immunodeficiency. This is a rare case of muscular-skeletal cryptococcal infection isolated in a subject affected with idiopathic CD4 lymphocytopenia.
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ranking = 1
keywords = idiopathic
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2/6. Pleural cryptococcosis with idiopathic CD4 positive T-lymphocytopenia.

    A 19-year-old man was admitted to our hospital because of chest pain. He was diagnosed as having pleural cryptococcosis by pleural biopsy. His CD4 positive T-lymphocyte count was low (< 300 microl) and there was no evidence of human immunodeficiency virus infection. He was successfully treated with fluconazole. However, his CD4 positive lymphocyte counts remained low after the recovery and he was diagnosed as idiopathic CD4 positive T-lymphocytopenia. Pleural cryptococcosis is rare and its predisposing condition is still controversial. To our knowledge, this is the first case of pleural cryptococcosis associated with idiopathic CD4 positive T lymphocytopenia.
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ranking = 1.2
keywords = idiopathic
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3/6. A case of pulmonary cryptococcosis with non-small cell lung cancer in idiopathic CD4 T-lymphocytopenia.

    cryptococcus neoformans commonly causes opportunistic infections in immunocompromised patients, especially in patients with AIDS. CD4 T-lymphocytopenia in AIDS indicates an increased risk of opportunistic infection and a decline in immunological function. Idiopathic CD4 T-lymphocytopenia (ICL) is characterized by depletions in the CD4 T-cell subsets, without evidence of hiv infection. Immunodeficiency can exist in the absence of laboratory evidence of hiv infection, and T-cell subsets should be evaluated in patients who present with unusual opportunistic infections. We report a case of pulmonary cryptococcosis and lung cancer in a patient with persistently low CD4 cell counts, without evidence of hiv infection.
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ranking = 0.8
keywords = idiopathic
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4/6. Cryptococcal meningitis presenting as uveitis.

    A patient presented with a posterior uveitis. An inferior plaque of retinal exudation was seen. Full investigation failed to establish a cause until six weeks later, when cryptococcal meningitis developed. The patient was immunocompetent. Exudation in relation to retinal vessels is unusual in idiopathic posterior uveitis, and cryptococcosis should be considered in the differential. diagnosis is by lumbar puncture or vitreous aspiration.
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ranking = 0.2
keywords = idiopathic
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5/6. Localized cutaneous cryptococcosis in an immunosuppressed man.

    Isolated cutaneous cryptococcosis developed in a 62-year-old white man with an idiopathic deficiency of t-lymphocytes. The patient was healthy, except for the cutaneous infection, and displayed no other evidence of an immunodeficiency disorder. An immunologic workup should be conducted in all patients with cryptococcal infection, regardless of their apparent health status.
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ranking = 0.2
keywords = idiopathic
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6/6. CD4 lymphopenia in a patient with cryptococcal osteomyelitis.

    cryptococcus neoformans is a rarely reported cause of osteomyelitis. In most cases, no obvious underlying condition is found. Immunological laboratory data, however, are not generally available. In the present case of cryptococcal osteomyelitis, idiopathic CD4 lymphopenia was detected. This immunodeficiency is found in cases of disseminated cryptococcosis by chance. Possibly, it may be one so far unrecognized underlying condition in cryptococcal osteomyelitis.
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ranking = 0.2
keywords = idiopathic
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