1/8. Opalescent dentine in two affected siblings.This report describes the dental findings and management of siblings in a family in which three generations had been affected by osteogenesis imperfecta Type IV with opalescent dentine. Hereditary opalescent dentine, or opalescent teeth, is a pathologic dental condition characterised by a disturbance of dentine formation that occurs concurrently with osteogenesis imperfecta. osteogenesis imperfecta is a genetically heterogenous group of systemic disorders of the connective tissue. The two siblings affected with opalescent dentine were treated under general anaesthesia, and included stainless steel crowns, extractions, and strip crowns on primary teeth. These reports highlight that appropriate treatment of the dentition of young patients with opalescent dentine should be carried out early in the primary dentition, and that this initial treatment can have long-term benefits in the mixed and permanent dentitions.- - - - - - - - - - ranking = 1keywords = dental (Clic here for more details about this article) |
2/8. Dental management of severe dentinogenesis imperfecta in a mild form of osteogenesis imperfecta.dentinogenesis imperfecta (DI), in which the teeth are discolored, translucent and brittle, can occur in isolation as a familial trait and as a component of the skeletal dysplasia osteogenesis imperfecta (OI). In a Cape Town family, 20 persons in 3 generations had mild OI, with the additional manifestation of severe DI. The family was assessed at the Dental Genetic Unit of the University of the Western Cape and appropriate dental treatment was provided. In this setting, a detailed treatment plan was devised for a severely affected woman. This plan proved to be efficient and cost effective, and the final outcome was pleasing to the patient. dentinogenesis imperfecta is not uncommon and may well be encountered in conventional dental practice. The necessary clinical expertise is within the scope of the skills of the general dentist.- - - - - - - - - - ranking = 1keywords = dental (Clic here for more details about this article) |
3/8. All-ceramic restorations for complete-mouth rehabilitation in dentinogenesis imperfecta: a case report.Prosthetic treatment of patients with dentinogenesis imperfecta is a challenge for the dental practitioner because numerous factors have to be considered. The use of all-ceramic restorations to rehabilitate the dentition of a young patient with dentinogenesis imperfecta is reported. Clinical and laboratory procedures are described.- - - - - - - - - - ranking = 0.5keywords = dental (Clic here for more details about this article) |
4/8. dentinogenesis imperfecta associated with osteogenesis imperfecta: report of two cases.osteogenesis imperfecta (OI) is a heritable systemic disorder of the connective tissue. dentinogenesis imperfecta (DI), which is sometimes an accompanying symptom of OI, belongs to a group of genetically conditioned dentin dysplasias and is characterized clinically by an opalescent amber appearance of the dentin. Although the teeth of DI cases wear more easily and excessively compared to normal teeth, they do not appear to be more susceptible to dental caries than normal teeth. Two cases of DI associated with OI are presented in this paper, with 1 case suffering from nursing bottle caries. The purposes of this paper are to present the dental and skeletal characteristics of moderately and mildly involved DI associated with OI, and to discuss the possible methods of dental treatment. patients with OI and opalescent teeth should be evaluated as soon as the deciduous teeth erupt; immediate dental involvement and oral hygiene instruction can be of help in reducing the necessity of extensive dental care.- - - - - - - - - - ranking = 2.5keywords = dental (Clic here for more details about this article) |
5/8. Overdentures in partial anodontia: simple solutions for complex problems.Congenital defects in children and adolescents can present complex and challenging dental problems, including arch discrepancies, palatal defects, and malposed or otherwise disrupted dentition. Traditional treatment is often time-consuming, expensive, and in extensive defects, frequently compromised at best. The overdenture prosthesis, often overlooked, is a relatively simple and expedient solution to many of these severe problems, and the prosthetic techniques are familiar and readily employed by dentists without specialized training. This article reviews the general principles employed in these techniques and offers examples of successful treatment for several of the more commonly occurring congenital dental defects.- - - - - - - - - - ranking = 1keywords = dental (Clic here for more details about this article) |
6/8. Splice site mutation causing deletion of exon 21 sequences from the pro alpha 2(I) chain of type I collagen in a patient with severe dentinogenesis imperfecta but very mild osteogenesis imperfecta.An eight-year-old boy was referred for dental assessment of dentinogenesis imperfecta, a full clinical examination also revealed joint hypermobility and some features of mild osteogenesis imperfecta although he had suffered few fractures. Analysis of the collagens produced by both gingival and skin fibroblast cultures showed the synthesis and intracellular retention of an abnormal alpha 2(I) chain that migrated faster than normal on SDS-PAGE. Cyanogen bromide peptide mapping of this intracellular protein indicated a probable deletion in the N-terminal peptide alpha 2CB4. The denaturation temperature of the mutant protein was only 36 degrees C, some 6 degrees C below normal. At 37 degrees C secretion of abnormal protein was not detectable but a lower temperature (30 degrees C) some was secreted into the medium. RT-PCR amplification of mRNA coding for alpha 2CB4 revealed a heterozygous deletion of the 108 bp exon 21 of COL1A2. Sequencing of PCR amplified genomic dna identified a G --> A transition in the moderately conserved 5 position of the IVS 21 5' consensus splice site causing the skipping of exon 21. Hybridization with allele-specific oligonucleotides showed no other family member had this base change. Since the cDNA deletion was associated with the (-) allele of a Pvu II polymorphism in exon 25 of COL1A2 we could demonstrate that the mutant pre-mRNA was alternatively spliced yielding both full length and deleted transcripts. family genotype analysis indicated the mutation had originated in the paternal alpha 2(I) gene.- - - - - - - - - - ranking = 0.5keywords = dental (Clic here for more details about this article) |
7/8. Carbamide peroxide bleaching of teeth with dentinogenesis imperfecta discoloration: report of a case.Carbamide peroxide dental bleaching has gained much popularity in the past 5 years. Because tooth discoloration caused by dentinogenesis imperfecta involves deep, dark, dentinal stain, practitioners might believe that affected teeth would be resistant to color improvement by bleaching. This article reports the successful use of carbamide peroxide at-home bleaching in a teenager with dentinogenesis imperfecta. Six-month treatment results are shown.- - - - - - - - - - ranking = 0.5keywords = dental (Clic here for more details about this article) |
8/8. dentinogenesis imperfecta: endodontic implications. Case report.dentinogenesis imperfecta is a hereditary disorder resulting in defective dentin in both the primary and secondary dentitions. The complications of dentinogenesis imperfecta are difficult to manage and provide a challenge to the dentist. This case report concerns treating an African American patient with dentinogenesis imperfecta who appeared for treatment with endodontic pathosis. It illustrates the need for appropriate and timely restorative treatment to prevent pulpal pathosis. Also demonstrated is the difficulty of endodontically treating dentinogenesis imperfecta teeth because of pulpal obliteration and abnormal dentin mineralization. Early and correct diagnosis of dentinogenesis imperfecta is imperative to enable appropriate preventive interventions and optimal dental treatment. Although pulpal pathosis is rarely reported with dentinogenesis imperfecta, endodontic treatment is occasionally necessary and has a guarded prognosis if initiated after pulp canal obliteration has occurred.- - - - - - - - - - ranking = 0.5keywords = dental (Clic here for more details about this article) |