1/4. Two cases of nickel dermatitis showing vitiligo-like depigmentations.The authors reviewed two patients showing "vitiligo-like depigmentations" where the skin had been in close contact with a metal spectacle frame made of nickel alloy. In spite of the hypersensitivity to nickel in both patients, they showed clinical and histologic findings indicate that the formation of "vitiligo-like depigmentation" does not result from posinflammatory hypopigmentation but from chemical hypomelanosis. We could not explain the underlying mechanisms; however, the speculation that the "vitiligo-like depigmentation" may come from the direct effect of the nickel itself, prompted us to report these cases.- - - - - - - - - - ranking = 1keywords = hypopigmentation (Clic here for more details about this article) |
2/4. Phototypesetting paper as a cause of allergic contact dermatitis in newspaper production workers.Tertiary butyl catechol (TBC), an antioxidant in phototypesetting paper, caused allergic contact dermatitis in several newspaper production workers. Five of eight tested workers had strong positive tests to the paper and to 0.1 percent TBC. Only one had subsequent hypopigmentation. The newspaper agency where they work now uses a product which contains no TBC. Sensitized workers have remained free of dermatitis unless exposed to advertising copy from outside sources.- - - - - - - - - - ranking = 1keywords = hypopigmentation (Clic here for more details about this article) |
3/4. Raccoon-like periorbital leukoderma from contact with swim goggles.A 12-year-old girl developed a periorbital leukoderma from contact with swim goggles. She had worn the same goggles the preceding year and re-used them after the leukoderma had cleared without any ill effects. The hypopigmentation was believed to be caused by the leakage of breakdown products in the neoprene rubber or glue. These breakdown products may have caused a toxic rather than an allergic reaction on skin contact, inhibiting melanin production possibly by competitive inhibition of tyrosine oxidation. These chemical compounds probably leaked from the goggles and were eventually exhausted. This possibility may explain why the leukoderma did not recur after re-use of the goggles.- - - - - - - - - - ranking = 1keywords = hypopigmentation (Clic here for more details about this article) |
4/4. An unusual hypopigmentation in occupational dermatology: presentation of a case and review of the literature.Contact dermatitis to cooling lubricants is commonly encountered in occupational dermatology, but it rarely induces pigmentary skin changes. It is sometimes difficult to differentiate between toxic leukoderma and postinflammatory hypopigmentation when examining a depigmentation. A differential diagnosis is described in the case of a 31-year-old metal worker, spending most of his time on a computer-numerically controlled machine, who presented with cumulative irritant hand dermatitis and secondary hypopigmentation. patch tests gave negative reactions to the European standard series, the disinfection and preservative series, the base preparation and emollient series, the metal series, the mechanical worker series as well as to the cooling lubricant itself. Atopy screening was positive for a variety of pollens. Based on biopsy findings, toxic leukoderma could be diagnosed even though none of the known melanotoxic compounds could be identified in his work environment. The patient was advised to avoid further contact with the regular composed cooling lubricant and the contact eczema improved dramatically, whereas the condition of hypopigmentation got better slowly within weeks under puva therapy.- - - - - - - - - - ranking = 7keywords = hypopigmentation (Clic here for more details about this article) |