1/15. A new syndrome comprising vertebral anomalies and multicystic kidneys.We report a dichorionic twin pregnancy in which both fetuses were affected by a similar pattern of multiple abnormalities. The afrocaribbean parents had a history of infertility, and the pregnancy was conceived using in vitro fertilisation with donor sperm. The features seen in the fetuses do not fit any previously described disorder well. We discuss the differential diagnoses and suggest that this may be an autosomal recessive disorder which has not been previously described.- - - - - - - - - - ranking = 1keywords = multicystic (Clic here for more details about this article) |
2/15. Multiple cystic and focal encephalomalacia in infancy and childhood with brain stem damage.Two cases are described in which damage to the brain stem was associated with extensive necrosis of the cerebral hemisphere. In the first case--a monochorionic twin--there was clear evidence that injury of an ischaemic or hypoxic type had occurred during fetal life and some evidence that an inadequate share of the placental circulation was an important aetiological factor. In the second case death occurred 4 yr after an asphyxial episode at birth. The lesions in the hemispheres and brain stem were extensive, although less than in the first example. The lesions are discussed in the context of our knowledge of the anatomy and physiology of the developing nervous system. Although they cannot as yet be fitted into the concepts of "critical periods" and "vulnerable periods" of development, this is perhaps because observations on human cases are scanty in comparison with the extensive animal studies which have been reported. The lesions are contrasted and compared with those seen in animals.- - - - - - - - - - ranking = 980.03425751315keywords = encephalomalacia (Clic here for more details about this article) |
3/15. Polymicrogyria in monozygous twins and an elder sibling.Monozygous twin births have been associated with brain lesions such as hydranencephaly, multicystic encephalomalacia, and porencephaly. Prenatal circulatory injury has been considered to be the cause. Polymicrogyria is rare but has been reported in autopsied cases. The sibship in this case report, comprising monozygotic male twins and their elder sister from the same non-consanguineous parents, all had global developmental delay. Brain MRI showed polymicrogyria. We suggest that, apart from circulatory compromise, genetic etiology must be implicated as the cause of polymicrogyria.- - - - - - - - - - ranking = 245.25856437829keywords = encephalomalacia, multicystic (Clic here for more details about this article) |
4/15. Multicystic encephalomalacia after first-trimester intrauterine fetal death in monochorionic twins.Multicystic encephalomalacia occurs in approximately 20% of surviving cotwins after second- and third-trimester intrauterine fetal death of one twin in monochorionic pregnancies. We report a case of multicystic encephalomalacia after the demise of a cotwin in the first trimester diagnosed by magnetic resonance imaging and confirmed pathologically.- - - - - - - - - - ranking = 1470.3013862697keywords = encephalomalacia, multicystic (Clic here for more details about this article) |
5/15. Brain damage to the survivor within 30 min of co-twin demise in monochorionic twins.Single fetal death in a twin pregnancy in the late second or early third trimester is associated with significant morbidity and mortality rate in the surviving co-twin, especially in monochorionic twin pregnancies. The common causes are twin-to-twin transfusion syndrome, chromosomal abnormalities, and congenital anomalies of the fetus or anomalies of the umbilical cord-placenta. Here we report a case of monochorionic twin pregnancy in which one fetus had a single umbilical artery (SUA) while the co-twin had two umbilical arteries. The twin with SUA died in utero at the 30th week of gestation and the other fetus was delivered by cesarean section immediately due to fetal distress diagnosed by cardiotocography. disseminated intravascular coagulation and multicystic encephalomalacia have been observed in the surviving neonate. This case and review of the literature suggest that neurologic complication rates are also increased in monochorionic twin pregnancies with single fetal demise despite the immediate delivery as in our case.- - - - - - - - - - ranking = 245.25856437829keywords = encephalomalacia, multicystic (Clic here for more details about this article) |
6/15. Acardius anceps with evidence of intrauterine vascular occlusion: report of a case and discussion of the pathogenesis.An acardiac anomaly (holoacardius anceps) showed advanced development of the head and lower body parts in the absence of all thoracic and upper abdominal viscera. Large vascular anastomoses in the vertebral canal formed the only blood supply to the head. The two-vessel umbilical cord of the acardius contained calcified mural thrombi in both vessels. Severe fetal hydrops resulted in an exceptionally large birth weight of 3720 g. fibroblasts from the acardius showed chromosomal mosaicism. The surviving co-twin was remarkable for a widely patent ductus arteriosus, unilateral multicystic renal dysplasia, and a normal chromosome complement. The circumscribed absence of organ development in the thorax and upper abdomen of the acardius and the vascular anatomy with thrombosis of the umbilical vessels suggest that an occlusion of thoracic and abdominal vessels was significant in the development of this acardiac malformation and should be considered as a possible pathogenetic mechanism in similar cases of acardia.- - - - - - - - - - ranking = 0.25keywords = multicystic (Clic here for more details about this article) |
7/15. Intracranial calcification in the infant and neonate: evaluation by sonography and CT.This study reports the sonographic and computed tomography (CT) findings in seven infants and neonates with intracranial calcifications and a spectrum of underlying disorders, including toxoplasmosis, cytomegalic inclusion disease, transverse/straight sinus thrombosis, and probable anoxia. Neurotropic infectious disease usually produced clumped or subependymal calcifications accompanied by sometimes bizarre ventricular configurations and prominent periventricular cystic encephalomalacia. Sonography failed to identify prospectively intracranial calcifications in two of the three patients without infection, although calcifications were visible in retrospect. overall, CT provided optimum visualization of intracranial calcifications.- - - - - - - - - - ranking = 245.00856437829keywords = encephalomalacia (Clic here for more details about this article) |
8/15. Cystic brain lesion in utero.Two autopsy cases of cystic brain lesion in utero are reported. One of them was a donor infant of twin transfusion syndrome. The baby died immediately after birth and showed multicystic encephalomalacia in the distribution of the anterior cerebral artery. The second baby was a stillborn infant with thanatophoric dwarfism with associated chronic periventricular leukomalacia (PVL). It was suggested that the multicystic encephalomalacia and chronic PVL found in the first and second cases were caused by persistent circulatory disturbances in utero.- - - - - - - - - - ranking = 490.51712875658keywords = encephalomalacia, multicystic (Clic here for more details about this article) |
9/15. Nonimmune hydrops fetalis in association with hemangioma of the umbilical cord.Nonimmune hydrops fetalis is becoming the predominant form of fetal hydrops due to the declining frequency of rh isoimmunization. Reported is the preterm delivery of a hydropic twin with umbilical cord and cutaneous hemangiomata. The unusual umbilical angiomatous malformation was associated with marked edema of the cord. This produced an ultrasonographic abnormality detected antenatally as a multicystic mass in close approximation to the fetal abdomen. The hydropic twin responded to aggressive neonatal management. It appears that hemangiomata of the umbilical cord may be causally related to fetal hydrops and may represent another entry in the differential diagnosis of this disorder.- - - - - - - - - - ranking = 0.25keywords = multicystic (Clic here for more details about this article) |
10/15. Intrauterine fetal demise in multiple gestation.Fifteen cases were reviewed over a five-year period at a perinatal centre with intrauterine demise of one member of a multiple gestation. Nine cases were monozygotic twin pairs, two were dizygotic, and two were triples . gestational age ranged from 27 to 39 weeks. The management protocol consisted of delivery in all cases after confirmation of the diagnosis. In 4 cases delivery was immediate because of spontaneous labor. In the other cases elective delivery was performed if the gestational age was 37 weeks or greater or there was evidence of preeclampsia or if amniocentesis revealed a mature lecithinsphingomyelin (L/S) ratio. steroids were given if the L/S was immature or the attempt at amniocentesis was unsuccessful and delivery was performed 48 hours after initiation of steroid therapy. cesarean section was the mode of delivery in 14 of the 15 cases. All of the cotwins and cotriplets survived. One survivor of a monozygous twin pair has multicystic encephalomalacia possibly implicating perinatal arterial occlusion or in utero disseminated intravascular coagulation (DIC). The intrauterine deaths are categorized into possibly avoidable deaths (2/15), unavoidable due to congenital anomalies (3/15), and unknown or unavoidable deaths (8/15).- - - - - - - - - - ranking = 245.25856437829keywords = encephalomalacia, multicystic (Clic here for more details about this article) |
| | Next -> |