Cases reported "Dysgerminoma"

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1/270. Primary mediastinal seminoma.

    Four new cases of primary mediastinal seminoma are presented, and the 103 previously reported cases reviewed. All of the tumors occurred in the anterior mediastinum, and generally appeared as lobulated noncalcified masses on chest radiography. Most patients were in the third and fourth decades, and about 30% were asymptomatic at the time of initial diagnosis. Although mediastinal seminoma is not commonly considered a cause of superior vena caval obstruction, about 10% of patients experience it. The tumors are radiosensitive and potentially radiocurable. A striking reduction in size of the tumor may be noted after radiation therapy. prognosis is generally good, with a 5-year survival rate of 75%. The controversy surrounding histogenesis of this tumor is reviewed, and the pathologic criteria for making the diagnosis presented.
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keywords = seminoma
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2/270. Malignant testicular tumors in three brothers.

    Three brothers out of four had malignant testicular tumors. The first of them had choriocarcinoma, the second seminoma, and the third teratocarcinoma of the testis.
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keywords = seminoma
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3/270. trisomy 21 associated with ovarian dysgerminoma.

    A 13-year-old G(0)P(0) white female with trisomy 21 presented with a complex pelvic mass. She underwent resection of the mass and complete staging for what was found to be a stage IIIC completely resected dysgerminoma. She was treated with three cycles of bleomycin, etoposide, and cisplatin chemotherapy and remains free of disease 1 year later. This association is presented as a rare case that may illustrate the relative increase in germ cell neoplasms in female patients with Down's syndrome. While the association of seminoma with Down's syndrome has been documented in a number of cases in males, the female counterpart of this tumor, dysgerminoma, in trisomy 21 has been reported quite infrequently. The potential for germ cell tumors in both male and female trisomy 21 is therefore illustrated.
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ranking = 0.16666666666667
keywords = seminoma
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4/270. The seminoma decoy: measurement of serum human chorionic gonadotropin in patients with seminoma.

    serum human chorionic gonadotropin levels were determined in 20 patients with histologically proved seminoma. The test was positive in 2 of the 20 patients and was predictive of non-seminomatous metastasis in each case. serum human chorionic gonadotropin is a useful tumor marker in detecting and following non-seminomatous metastases in men with pure seminoma of the testis.
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ranking = 2
keywords = seminoma
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5/270. Primary retroperitoneal seminoma. Report of a case and review of the literature.

    A large retroperitoneal seminoma in a 42-year-old man is described, which appears to have arisen as a primary tumor at that site. The mechanism for the development of extragonadal germ cell tumors is discussed, and the criteria for their distinction from metastatic occult or regressed testicular neoplasms are re-emphasized. awareness by clinicians of this entity may save individuals with this neoplasm from unnecessary orchiectomy.
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keywords = seminoma
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6/270. Nonseminomatous germ cell tumor arising in splenogonadal fusion.

    Splenogonadal fusion is a rare congenital malformation in which the spleen is abnormally connected to the gonads or to the mesonephric derivatives. A few more than 150 cases have been described in the world literature. We report an additional case of splenogonadal fusion. A nonseminomatous germ cell tumor was found in the testicle involved in this splenogonadal fusion. To our knowledge, this is the third reported case of a testicular neoplasm associated with splenogonadal fusion and the first reported case of intra-abdominal nonseminomatous germ cell testicular tumor arising in this rare anomaly. The literature pertaining to splenogonadal fusion and the testicular tumor arising in this anomaly is briefly reviewed.
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ranking = 1
keywords = seminoma
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7/270. Malignant thymoma with penetration into the gastrointestinal tract: report of two cases.

    Two cases of thymoma, one epiithelial and one seminoma type are presented. In both instances, the thymoma infiltrated and later perforated the gastrointestinal tract by direct extension. One is the 30th reported case of thymoma with extrathoracic metastasis; this patient had metastasis to the bone marrow and kidney. Neither patient had myasthenia gravis associated with the thymic tumor.
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ranking = 0.16666666666667
keywords = seminoma
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8/270. A case of simultaneous bilateral nonseminomatous testicular tumors in persistent mullerian duct syndrome.

    Persistent mullerian duct syndrome is characteristically associated with unilateral or bilateral cryptorchidism. Like other undescended testes, these gonads are at an increased risk of malignant transformation. We report a case of synchronous bilateral mixed germ cell tumors in the cryptorchid testes of a patient with the persistent mullerian duct syndrome.
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ranking = 0.66666666666667
keywords = seminoma
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9/270. Humoral hypercalcemia in seminomas.

    Seminomas are germ cell tumors that are rarely associated with hypercalcemia. In this report, four cases of seminoma with concomitant hypercalcemia are presented and another three from the literature are reviewed. All seven patients exhibited hypercalcemia with a normal serum concentration of inorganic phosphorus and no evidence of skeletal metastases. The peripheral venous level of parathyroid hormone (PTH) was normal in four of the five patients in whom it was measured. The serum concentration of calcitriol was elevated in the two patients in whom it was measured. After systemic chemotherapy, the serum "corrected" total calcium concentration returned to normal and remained normal; the decrease in the levels temporally paralleled the decrease in tumor volume. Both patients with elevated calcitriol levels remained eucalcemic after treatment of the malignancy, suggesting that the increased serum calcitriol level was linked to the development of hypercalcemia as this humoral agent was inappropriately elevated by patients with this syndrome. In contrast to many forms of malignancy, the development of hypercalcemia did not adversely affect the prognosis of the patients with seminoma, since all seven patients entered complete remission. hypercalcemia appears to be heretofore unrecognized paraneoplastic syndrome associated with seminoma.
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ranking = 1.1666666666667
keywords = seminoma
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10/270. Metastatic testicular seminoma of the cervicothoracic spine.

    A case of metastatic testicular seminoma affecting the cervico-thoracic spine is reported along with its clinical and radiographic findings. Case progression is discussed.
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ranking = 0.83333333333333
keywords = seminoma
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