1/20. Ultrastructural changes in a case of mucoid degeneration of the brachial artery.An electron microscopic (EM) description of mucoid degeneration of the brachial artery in a 67 year old man is presented. In this case, the affected artery showed mucoid degeneration of the intima and media circumferentially, dissecting and destroying the muscle fibres. Ultrastructurally, mucoid degenerating muscle cells showed numerous large mucin-containing vesicles in the cytoplasm. Cells were widely separated by large accumulation of mucoid material, which appeared to penetrate the extracellular collagen fibre bundles. Most of the nuclei of the smooth muscle cells displayed typical necrotic changes undergoing dissolution or having already broken up into discrete fragments. This case of intimo-medial degeneration (IMMD) suggests that the condition could arise spontaneously anywhere in the inner coats of the arterial system away from the vessels that are close to synovial joints. This is a rare presentation of IMMD of arteries, which has been described mainly in the aorta and its major branches.- - - - - - - - - - ranking = 1keywords = intima (Clic here for more details about this article) |
2/20. Embolized ischemic lesions of toes in an afibrinogenemic patient: possible relevance to in vivo circulating thrombin.Fibrinogen plays a complex role in hemostasis, thrombosis, and vascular disease. Hyperfibrinogenemia is an independent vascular risk factor and dysfibrinogenemia can provoke thrombosis. afibrinogenemia is usually responsible for hemorrhagic diathesis, and unexpected ischemic lesions are intriguing. We report the case of an afibrinogenemic patient, who at the age of 30 developed ischemic lesions of the feet related to severe stenosis of the iliac and hypogastric arteries. The biopsy of the iliac artery lesion showed an intense myointimal hyperplasia. We performed standard hemostatic analysis and analyzed the activation markers of platelets and coagulation factors and the kinetics of thrombin generation in the patient and in normal control plasmas treated or not with reptilase. Occlusive arterial lesions were attributed to a disruptive hematoma penetrating the vascular lumen. Thrombin concentration after calcium addition increase markedly in the afibrinogenemic patient and in defibrinated normal plasma, as compared to untreated normal plasma. Thrombin-antithrombin complexes (T-AT) were markedly enhanced while F1 2 prothrombin fragments stayed in the normal range. These results suggested activation of coagulation and in vivo circulating thrombin. Thrombin activates the platelets that secrete growth factors for smooth muscle cells and generate the intimal hyperplasia. Recurrent hemorrhage within the vessel wall might induce injury and local thrombin generation. Thrombin not trapped by the clot is available for platelet activation and smooth muscle cell migration and proliferation. The absence of a protective fibrin cap on the intima might account for intima vulnerability and embolization. afibrinogenemia appears in this paradoxical situation as a vascular risk factor.- - - - - - - - - - ranking = 4keywords = intima (Clic here for more details about this article) |
3/20. Arterial occlusion secondary to methylmethacrylate use.We are reporting a new complication of the use of methylmethacrylate, namely occlusion of the iliac artery with embolization. We believe that the occlusion is related to trauma to the intima by the heat of polymerization created by methylmethacrylate, with resultant thrombosis. In view of the initial failure of embolectomy alone, we suggest direct attack on the involved artery with prosthetic replacement, and management of the distal embolus by embolectomy with Fogarty catheters.- - - - - - - - - - ranking = 1keywords = intima (Clic here for more details about this article) |
4/20. Management of a "saddle" embolus at the popliteal bifurcation by a variation of the "push and park" approach. A case report.We present a modification of a previously reported endovascular technique where a large embolus was "pushed and parked" into a diseased artery. A saddle embolus at the bifurcation of the popliteal artery, which occurred as a complication after a percutaneous subintimal recanalization, was pushed and parked into the tibio-peroneal trunk. This was achieved using 2 balloon catheters, one to disengage the embolus from the anterior tibial artery, and the other to push the embolus into the tibio-peroneal trunk, thus establishing flow into the anterior tibial artery. Pushing and parking an embolus into a less useful vessel when all attempts at catheter embolectomy have failed is a simple and quick method which should be borne in mind by all vascular interventionalists.- - - - - - - - - - ranking = 1keywords = intima (Clic here for more details about this article) |
5/20. Late upper extremity embolic complications of occluded axillofemoral grafts.The use of axillary femoral grafting in the treatment of patients at high risk for aortoiliac reconstruction has become a widely accepted treatment modality. ischemia and even loss of the donor upper extremity have been reported to occur early after graft occlusion. This report describes three patients who developed emboli to the upper extremity at nine, 15, and 34 months following occlusion of their axillary femoral graft. Based on our experience, we consider an occluded axillofemoral graft a permanent threat to the viability of the donor upper extremity. Anatomic changes suggestive of potential ischemia include: presence of a blind pouch in the graft stump, or "Y" elongation of the artery with proliferative changes in the intima.- - - - - - - - - - ranking = 1keywords = intima (Clic here for more details about this article) |
6/20. Complications of anomalous origin of the right subclavian artery: case report and review of the literature.A 35-year-old black woman presented with thrombosis of an anomalous right subclavian artery and distal arterial embolization. Initially, her right subclavian artery was reimplanted onto the common carotid artery, and a brachial artery embolectomy plus intraoperative thrombolytic therapy were used to reopen her distal arterial circulation. When her brachial artery repair thrombosed the following day, a distal ulnar artery bypass and repeat thrombolytic therapy were required to restore arterial patency. Six months later, she returned with severe, progressive, neointimal hyperplasia of her brachial artery and a second attempt at arterial reconstruction was unsuccessful. She eventually required a right below-elbow amputation. This patient demonstrated an anomalous right subclavian artery that presented with distal embolization without an antecedent history of severe atherosclerotic disease or the development of a right subclavian artery aneurysm. A review of the medical literature relating to complications of this anomaly is provided.- - - - - - - - - - ranking = 1keywords = intima (Clic here for more details about this article) |
7/20. aneurysm formation after dynamic catheter assisted balloon angioplasty.A male patient underwent recanalisation of a symptomatic popliteal artery occlusion using a dynamic angioplasty catheter, followed by balloon dilatation. A small subintimal dissection lead to an acute reocclusion. Repeat balloon angioplasty reopened the occlusion but was complicated by a distal embolus which was successfully treated by thrombolytic therapy followed by oral anticoagulation. angiography 9 months later, demonstrated an aneurysm at the site of initial dissection. The artery remained patent and the patient free of claudication. A causal relationship between dynamic angioplasty and subsequent aneurysm formation is suggested and the possible predisposing factors discussed.- - - - - - - - - - ranking = 1keywords = intima (Clic here for more details about this article) |
8/20. A case of aortic intimal sarcoma manifested with acutely occurring hypertension and aortic occlusion.Primary tumor of the aorta is extremely rare. An instance of aortic intimal sarcoma, namely fibromyxosarcoma, which extended from the beginning of the descending aorta to 7 cm above the abdominal bifurcation, with clinical evidence of acutely occurring hypertension, arterial embolism of the lower extremities, renal infarction, and aortic occlusion in a 50-year-old male is reported. The tumor was limited to the intima and composed of spindle-shaped tumor cells with abundant myxoid extracellular matrices. The tumor cells were negative for Factor VIII, desmin, or myoglobin, but were positive for vimentin or factor xiiia in immunoperoxidase studies. An electron microscopic examination revealed a large amount of rough endoplasmic reticulum in the cytoplasm. Parenchymal metastases were observed in both the lungs and thoracic vertebrae. A review of literature on the clinical and pathological aspects of the tumor was made.- - - - - - - - - - ranking = 6keywords = intima (Clic here for more details about this article) |
9/20. Renal failure following radiologic procedures.Radiologic procedures that employ intravascular contrast material with or without angiography may lead to renal failure. In procedures that use intravenous contrast alone, the mechanism of renal injury is not precisely known, but direct toxicity to renal tubular cells is likely to be a major factor. Ionic and nonionic contrast agents are both capable of causing this adverse reaction. Renal failure occurring during angiography may also be secondary to the effects of radiocontrast, but the additional possibility that micro cholesterol emboli have been dislodged from atheroma located on the intima of large vessels must be considered. The acute or subacute development of renal failure in the presence of skin changes (livido reticularis), hypertension, multiple organ failure or dysfunction, and a fatal outcome favors the later diagnosis.- - - - - - - - - - ranking = 1keywords = intima (Clic here for more details about this article) |
10/20. popliteal artery entrapment syndrome with distal embolization. A report of two cases.The popliteal vascular entrapment syndrome has been recognized as a cause of arterial occlusion in young males for several decades. The ischemia is usually caused by thrombosis of the popliteal artery due to intimal trauma or aneurysm formation. Distal embolization to the tibial arteries and to the foot arch and digital vessels is common but is not emphasized in the literature. This distal embolization may precipitate severe ischemia which may preclude reconstruction or compromise the results of repair of the popliteal lesion. Early repair of the muscle anomaly is advocated even in the asymptomatic limb. Two patients with bilateral popliteal artery entrapment causing unilateral popliteal occlusion with distal embolization are reported.- - - - - - - - - - ranking = 1keywords = intima (Clic here for more details about this article) |
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