1/8. Myopericarditis associated with central European tick-borne encephalitis.The case of an 11-year-old child with acute myopericarditis associated with central European tick-borne encephalitis is presented. Cardiac involvement was demonstrated by pericardial effusion, elevated serum concentration of troponin-I and cardiac arrhythmia. Co-infections with enteroviruses, borrelia burgdorferi or the agent of human granulocytic ehrlichiosis were excluded. Recovery was uneventful. CONCLUSION: Central European tick-borne encephalitis can be complicated by cardiac involvement.- - - - - - - - - - ranking = 1keywords = burgdorferi (Clic here for more details about this article) |
2/8. Double infection with tick borne encephalitis virus and borrelia burgdorferi sensu lato.The limited information on co-infection with borrelia burgdorferi sensu lato and tick-borne encephalitis (TBE) virus was a stimulus for presentation of two patients with well-defined double infection of the central nervous system. TBE virus and B. burgdorferi sensu lato infections are searched for in all patients with lymphocytic meningitis and/or meningoencephalitis admitted to our department. During the last ten years we identified two patients who had ELISA IgM and IgG antibodies to TBE virus in serum and a positive PCR result for TBE virus in cerebrospinal fluid as well as B. burgdorferi sensu lato isolated from cerebrospinal fluid. Intrathecal production of borrelial antibodies was not proven in either of the two patients. These findings show that in patients with acute lymphocytic meningitis originating in regions endemic for Lyme borreliosis and TBE, the possibility of concomitant infection should be considered.- - - - - - - - - - ranking = 7keywords = burgdorferi (Clic here for more details about this article) |
3/8. Concomitant tickborne encephalitis and human granulocytic ehrlichiosis.We report a patient with febrile illness and epidemiologic and clinical findings consistent with human granulocytic ehrlichiosis and tickborne encephalitis, in whom infection with anaplasma phagocytophilum was demonstrated by polymerase chain reaction and seroconversion. Tickborne encephalitis virus infection was established by serum immunoglobulin (Ig) M and IgG antibodies.- - - - - - - - - - ranking = 0.0012002959539843keywords = lyme (Clic here for more details about this article) |
4/8. Fatal encephalitis caused by concomitant infection with tick-borne encephalitis virus and borrelia burgdorferi.We describe a 38-year-old farmer from the southwestern archipelago of finland where both tick-borne encephalitis (TBE) virus and borrelia burgdorferi are endemic. He presented with fever and headache, developed severe meningoencephalitis in 3 days, and, after 1 month, died without regaining consciousness. High titers of IgG and IgM antibodies to TBE virus were present in both serum and CSF. serology for Borrelia was negative. autopsy revealed necrotizing encephalitis and myelitis with involvement of the dorsal root ganglion. With use of polymerase chain reaction tests, segments of two separate genes of B. burgdorferi were amplified from the patient's CSF. This case demonstrates that the possibility of dual infection should be considered for patients residing in geographic areas where ixodes ticks may carry both the TBE virus and B. burgdorferi. We believe that the most severe damage in this case was caused by TBE virus rather than by B. burgdorferi. Nevertheless, the coinfection might have contributed to the fatal outcome that has not been previously observed in Finnish patients with TBE.- - - - - - - - - - ranking = 8.001200295954keywords = burgdorferi, lyme (Clic here for more details about this article) |
5/8. Tick-borne encephalitis and concomitant infection with borrelia burgdorferi.Concomitant tick-borne encephalitis and Borrelia infection in 43 year old farmer living in a village on the border of the Knyszyn Forest was described. diagnosis was based on anamnesis and objective examination, and was confirmed by serological tests.- - - - - - - - - - ranking = 4keywords = burgdorferi (Clic here for more details about this article) |
6/8. Tick-borne encephalitis: possibly a fatal disease in its acute stage. PCR amplification of TBE rna from postmortem brain tissue.Tick-borne encephalitis has occurred regularly in europe since it was first diagnosed in 1931 by Schneider. The mortality rate of patients with this disease is 1-2%. death usually occurs in the acute stage of illness. A case report of a 28-year-old patient from slovenia, who died shortly after the onset of tick-borne encephalitis, is described. The clinical course of disease, results of serological tests, neuropathological findings and polymerase chain reaction amplification of parts of viral genome from postmortem brain tissues are presented.- - - - - - - - - - ranking = 0.0012002959539843keywords = lyme (Clic here for more details about this article) |
7/8. Isolation of a flavivirus related to the tick-borne encephalitis complex from human cases in saudi arabia.A flavivirus related to the tick-borne encephalitis complex was isolated from the blood of 6 male butchers, aged 24-39 years, in Jeddah, saudi arabia in November and December 1995. Two of the patients died and the other 4 recovered completely. Four more patients, 3 males and 1 female, were diagnosed serologically by immunoglobulin m capture enzyme-linked immunosorbent assay and seroconversion in acute and convalescent blood samples examined by indirect immunofluorescent test using vero cells infected with the isolated virus. The virus identity was confirmed at the Centers for disease Control and Prevention, Fort Collins, colorado, USA, by the polymerase chain reaction; it was closely related to Kayasanur Forest disease virus. All infected patients had similar clinical and laboratory symptoms and signs, including fever, headache, generalized body aches, arthralgia, anorexia, vomiting, leucopenia, thrombocytopenia, elevated liver enzymes (serum glutamic oxalacetic and serum glutamic pyruvic transaminases), elevated creatinine phosphokinase, and elevated blood urea. One patient developed symptoms of encephalitis, but survived without any sequel. skin rash developed in 2 patients, morbilliform on the hands, feet, and lower abdomen of one patient and purpuric associated with melaena in the second patient. Eight of the 10 confirmed patients were working with sheep, and the disease may be a zoonotic viral infection.- - - - - - - - - - ranking = 0.0012002959539843keywords = lyme (Clic here for more details about this article) |
8/8. Clinical value of specific intrathecal production of antibodies.The production of intrathecal antibodies is considered a highly specific marker for an infection of the central nervous system (CNS), e.g. borreliosis or tick-borne encephalitis (TBE). To investigate the validity of this assumption, we examined records of patients who had been hospitalized between 1989 and 1995, who were tested for borreliosis (n = 8003) and TBE (n = 904) and whose cerebrospinal fluid (CSF) had subsequently tested positive for intrathecal production of antibodies. The time period between the beginning of the symptoms and the time of the CSF examination ranged from one day to six weeks. Seventy-seven patients showed a production of intrathecal antibodies against borrelia burgdorferi. Three of these patients were false positives with no history and no clinical signs of neuroborreliosis. In two cases, this was due to a non-specific cross-reaction caused by a preceding infection with syphilis. The third false positive was possibly caused by an earlier administration of immunoglobulins. Three patients showed a production of intrathecal antibodies against TBE virus. Two of these patients were false positives. In one case, we suspect that the production of intrathecal antibodies was caused by a non-specific immune reaction during an acute neuroborreliosis. One year earlier, the patient had contact with TBE virus through a vaccination against TBE. The cause of the second false positive is unclear, the clinical findings, acute encephalitis and the serological analysis suggest a cross-reaction with a virus similar to TBE. A specific intrathecal production of antibodies is not a proof for an infection of the CNS. In unclear cases, one should carry out a Western blot analysis or, if one suspects a case of TBE, a neutralization test.- - - - - - - - - - ranking = 1keywords = burgdorferi (Clic here for more details about this article) |