Cases reported "Epistaxis"

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1/7. Severe epistaxis in brucellosis-induced isolated thrombocytopenia: a report of two cases.

    brucellosis can present initially with its haematological findings including anaemia, leukopenia, and thrombocytopenia and may mimic primary haematological diseases. We present two patients with complaints of severe epistaxis and isolated thrombocytopenia which was initially diagnosed as idiopathic thrombocytopenic purpura but which was finally attributed to brucellosis. Their platelet count reverted to normal within 2-3 weeks of initiating antibrucellosis treatment with recovery from the disease.
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ranking = 1
keywords = thrombocytopenic, purpura
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2/7. bernard-soulier syndrome in a Turkish family.

    This report describes the first Turkish family to be diagnosed with bernard-soulier syndrome. The family consists of nine members (two parents, three sons and four daughters). The parents were first cousins. The index case, a 22 year-old-man, had a history of haemorrhagic diathesis with thrombocytopenia, giant platelets in the peripheral blood smear and a prolonged bleeding time. Refractory idiopathic thrombocytopenic purpura had been diagnosed elsewhere and a splenectomy had been performed six months previously. ristocetin agglutination of platelets was defective and flow cytometry analysis of platelet membrane glycoprotein showed markedly reduced expression of glycoprotein lb (2.1%). bernard-soulier syndrome was diagnosed. Increased mean platelet volume was found in both parents, one son and three daughters. The other son and daughter were normal.
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ranking = 1
keywords = thrombocytopenic, purpura
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3/7. Severe bleeding symptoms in refractory idiopathic thrombocytopenic purpura: a case successfully treated with melatonin.

    The prognosis of patients with idiopathic thrombocytopenic purpura refractory to corticosteroids and splenectomy (refractory ITP) is poor; these patients present high morbidity from disease and its treatment and have a mortality rate of approximately 16%. A patient is reported with severe bleeding symptoms related to refractory ITP successfully treated with melatonin.
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ranking = 5
keywords = thrombocytopenic, purpura
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4/7. Immune thrombocytopenic purpura associated with brucella and toxoplasma infections.

    Bacterial and protozoal infections can cause thrombocytopenia and may mimic idiopathic thrombocytopenic purpura (ITP). brucella species and toxoplasma are among the infectious agents with protean clinical manifestations which may induce immune thrombocytopenia. In rare cases, thrombocytopenia can be severe and may result bleeding into the skin and from mucosal sites. Prompt recognition of this complication and aggressive therapy are essential, since the mortality associated with bleeding into the central nervous system is high. We report two patients with complaints of severe epistaxis and thrombocytopenia associated with brucellosis and toxoplasmosis. Thrombocytopenic purpura in these cases responded well to the high-dose corticosteroid treatment with platelet recovery within 2-3 days. For cases with infection-induced immune thrombocytopenic purpura, short-term high-dose corticosteroids may be applied as an urgent therapy without worsening of the clinical condition.
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ranking = 6.2102134226254
keywords = thrombocytopenic, purpura
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5/7. Thrombocytopenic purpura during the incubation period of rubella.

    A child with idiopathic thrombocytopenic purpura (ITP) which started eight days before the appearance of rubella rash is described. All previous reports described ITP after or occasionally simultaneous with the onset of rubella rash. The onset of purpura in this patient was during the incubation of rubella before the initiation of immune response, suggesting that in some patients the mechanism of platelet damage in ITP associated with rubella is through a direct effect of the virus, rather than by circulating antibodies.
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ranking = 2.0510671131271
keywords = thrombocytopenic, purpura
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6/7. Nasal packing with porcine fatty tissue for epistaxis complicated by qualitative platelet disorders.

    Medications and renal failure are common causes of qualitative platelet disorders. epistaxis occurring in these settings may be unresponsive to conventional therapy. Two patients with epistaxis and platelet dysfunction are presented who were successfully treated with porcine nasal packing. The technique, previously shown effective in thrombocytopenic patients, is inexpensive, simple, and effective. The procedure is described and its possible modes of action are discussed. The pathogenesis of platelet disorders induced by uremia and aspirin are also briefly discussed.
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ranking = 0.78978657737458
keywords = thrombocytopenic
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7/7. The role of splenectomy in the treatment of thrombocytopenic purpura due to systemic lupus erythematosus.

    splenectomy in the treatment of thrombocytopenic purpura associated with lupus erythematosus has afforded satisfactory overall results in a group of ten patients. Postoperative deaths occurred in two patients, each of whom had significant underlying problems. Clinical manifestations of SLE-induced thrombocytopenic purpura included ecchymoses, petechiae, menorrhagia, epistaxis, and hematuria. splenectomy in this disorder should be reserved for cases in whom corticosteroids do not produce satisfactory results, or in whom unacceptably high doses are required. Follow-up indicates long term control of thrombocytopenic purpura following splenectomy.
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ranking = 7
keywords = thrombocytopenic, purpura
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